Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T55273 Target Info
Target Name Delta-like protein 4 (DLL4)
Synonyms UNQ1895/PRO4341; Drosophila Delta homolog 4; Deltalike protein 4; Delta4
Target Type Clinical trial Target
Gene Name DLL4
UniProt ID
DLL4_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: alpha-L-Fucose Ligand Info
Structure Description Human DLL4 C2-EGF3 PDB:5MVX
Method X-ray diffraction Resolution 2.17 Å Mutation No [1]
PDB Sequence
SGVFQLQLQE
36
FINERGVLAS
46
GRPCEPGCRT
56
FFRVCLKHFQ
66
AVVSPGPCTF
76

GTVSTPVLGT
86
NSFAVRDDSS
96
GGGRNPLQLP
106
FNFTWPGTFS
116
LIIEAWHAPG
126

DDLRPEALPP
136
DALISKIAIQ
146
GSLAVGQNWL
156
LDEQTSTLTR
166
LRYSYRVICS
176

DNYYGDNCSR
186
LCKKRNDHFG
196
HYVCQPDGNL
206
SCLPGWTGEY
216
CQQPICLSGC
226

HEQNGYCSKP
236
AECLCRPGWQ
246
GRLCNECIPH
256
NGCRHGTCST
266
PWQCTCDEGW
276

GGLFCDQDLN
286
YCTHHSPCKN
296
GATCSNSGQR
306
SYTCTCRPGY
316
TGVDCELEL
Residue
Distance (Å)
GLY297
3.759
ALA298
4.312
THR299
1.375
Residue
Distance (Å)
THR311
3.511
CYS312
3.501
ARG313
4.223
References  Top
REF 1 Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J. 2017 Aug 1;36(15):2204-2215.

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