Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53764 | Target Info | |||
| Target Name | Prolyl endopeptidase FAP (FAP) | ||||
| Synonyms | Integral membrane serine protease; Fibroblast activation protein alpha; FAP; Antiplasmin-cleaving enzyme; APCE; 170-kDa melanoma membrane-bound gelatinase | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | FAP | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Linagliptin | Ligand Info | |||||
| Structure Description | Structure of human FAPalpha in complex with linagliptin | PDB:6Y0F | ||||
| Method | X-ray diffraction | Resolution | 2.92 Å | Mutation | No | [1] |
| PDB Sequence |
NTMRALTLKD
46 ILNGTFSYKT56 FFPNWISGQE66 YLHQSADNNI76 VLYNIETGQS86 YTILSNRTMK 96 SVNASNYGLS106 PDRQFVYLES116 DYSKLWRYSY126 TATYYIYDLS136 NGEFVRGNEL 146 PRPIQYLCWS156 PVGSKLAYVY166 QNNIYLKQRP176 GDPPFQITFN186 GRENKIFNGI 196 PDWVYEEEML206 ATKYALWWSP216 NGKFLAYAEF226 NDTDIPVIAY236 SYYGDEQYPR 246 TINIPYPKAG256 AKNPVVRIFI266 IDTTYPAYVG276 PQEVPVPAMI286 ASSDYYFSWL 296 TWVTDERVCL306 QWLKRVQNVS316 VLSICDFRED326 WQTWDCPKTQ336 EHIEESRTGW 346 AGGFFVSTPV356 FSYDAISYYK366 IFSDKDGYKH376 IHYIKDTVEN386 AIQITSGKWE 396 AINIFRVTQD406 SLFYSSNEFE416 EYPGRRNIYR426 ISIGSYPPSK436 KCVTCHLRKE 446 RCQYYTASFS456 DYAKYYALVC466 YGPGIPISTL476 HDGRTDQEIK486 ILEENKELEN 496 ALKNIQLPKE506 EIKKLEVDEI516 TLWYKMILPP526 QFDRSKKYPL536 LIQVYGGPCS 546 QSVRSVFAVN556 WISYLASKEG566 MVIALVDGRG576 TAFQGDKLLY586 AVYRKLGVYE 596 VEDQITAVRK606 FIEMGFIDEK616 RIAIWGWSYG626 GYVSSLALAS636 GTGLFKCGIA 646 VAPVSSWEYY656 ASVYTERFMG666 LPTKDDNLEH676 YKNSTVMARA686 EYFRNVDYLL 696 IHGTADDNVH706 FQNSAQIAKA716 LVNAQVDFQA726 MWYSDQNHGL736 SGLSTNHLYT 746 HMTHFLKQCF756 S
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human FAPalpha in complex with linagliptin | ||||
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