Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53588 | Target Info | |||
| Target Name | Bacterial NADH-dependent enoyl-ACP reductase (Bact fabI) | ||||
| Synonyms | Enoyl[acylcarrierprotein] reductase [NADH] FabI; ENR of Mycobacterium tuberculosis | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | Bact fabI | ||||
| Biochemical Class | Short-chain dehydrogenases reductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Triclosan | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF ENOYL REDUCTASE INHIBITION BY TRICLOSAN | PDB:1QSG | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [1] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IRTLAASGIK201 DFRKMLAHCE 211 AVTPIRRTVT221 IEDVGNSAAF231 LCSDLSAGIS241 GEVVHVDGGF251 SIAAMNEL |
|||||
|
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Indole Naphthyridinone | Ligand Info | |||||
| Structure Description | E. coli Enoyl Reductase in complex with NAD and SB611113 | PDB:1MFP | ||||
| Method | X-ray diffraction | Resolution | 2.33 Å | Mutation | No | [2] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IRTLAASGIK201 DFRKMLAHCE 211 AVTPIRRTVT221 IEDVGNSAAF231 LCSDLSAGIS241 GEVVHVDGGF251 SIAAMNEL |
|||||
|
|
GLY93
3.878
PHE94
2.915
ALA95
2.782
PRO96
4.618
GLY97
4.180
LEU100
3.990
TYR146
3.027
ILE153
4.065
PRO154
4.202
ASN155
3.985
TYR156
2.998
|
|||||
| Ligand Name: 4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole | Ligand Info | |||||
| Structure Description | E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654 | PDB:1I2Z | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [3] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IRTLAASGIK201 DFRKMLAHCE 211 AVTPIRRTVT221 IEDVGNSAAF231 LCSDLSAGIS241 GEVVHVDGGF251 SIAAMNE |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .654 or .6542 or .6543 or :3654;style chemicals stick;color identity;select .A:93 or .A:94 or .A:95 or .A:96 or .A:97 or .A:100 or .A:146 or .A:156 or .A:159 or .A:163 or .A:191 or .A:196 or .A:197 or .A:199 or .A:200 or .A:203 or .A:206; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: Nicotinamide-Adenine-Dinucleotide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF ENOYL REDUCTASE INHIBITION BY TRICLOSAN | PDB:1QSG | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [1] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IRTLAASGIK201 DFRKMLAHCE 211 AVTPIRRTVT221 IEDVGNSAAF231 LCSDLSAGIS241 GEVVHVDGGF251 SIAAMNEL |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NAD or .NAD2 or .NAD3 or :3NAD;style chemicals stick;color identity;select .A:13 or .A:14 or .A:15 or .A:16 or .A:19 or .A:20 or .A:21 or .A:40 or .A:44 or .A:63 or .A:64 or .A:65 or .A:66 or .A:91 or .A:92 or .A:93 or .A:94 or .A:119 or .A:144 or .A:145 or .A:146 or .A:156 or .A:159 or .A:163 or .A:189 or .A:190 or .A:191 or .A:192 or .A:194 or .A:195 or .A:196 or .A:197 or .A:203; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY13
2.861
VAL14
3.875
ALA15
3.400
SER16
4.976
SER19
2.608
ILE20
2.975
ALA21
4.593
GLN40
2.785
LEU44
3.863
CYS63
3.589
ASP64
2.994
VAL65
3.152
ALA66
4.066
SER91
3.240
ILE92
3.388
GLY93
3.626
PHE94
4.175
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 1,3,4,9-Tetrahydro-2-(hydroxybenzoyl)-9-[(4-hydroxyphenyl)methyl]-6-methoxy-2H-pyrido[3,4-B]indole | Ligand Info | |||||
| Structure Description | E. Coli Enoyl Reductase +NAD+SB385826 | PDB:1I30 | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [4] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IRTFRKMLAH209 CEAVTPIRRT 219 VTIEDVGNSA229 AFLCSDLSAG239 ISGEVVHVDG249 GFSIAAMN
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .826 or .8262 or .8263 or :3826;style chemicals stick;color identity;select .A:146 or .A:156 or .A:159 or .A:163 or .A:191 or .A:203 or .A:206; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 3-(6-Aminopyridin-3-YL)-N-methyl-N-[(1-methyl-1H-indol-2-YL)methyl]acrylamide | Ligand Info | |||||
| Structure Description | Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Acrylamide Inhibitor | PDB:1LXC | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [5] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IRTLFRKMLA208 HCEAVTPIRR 218 TVTIEDVGNS228 AAFLCSDLSA238 GISGEVVHVD248 GGFSIAAMNE258 L |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AYM or .AYM2 or .AYM3 or :3AYM;style chemicals stick;color identity;select .A:93 or .A:94 or .A:95 or .A:97 or .A:100 or .A:146 or .A:153 or .A:154 or .A:155 or .A:156 or .A:159 or .A:163 or .A:191 or .A:203 or .A:206; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 3-[(Acetyl-methyl-amino)-methyl]-4-amino-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-benzamide | Ligand Info | |||||
| Structure Description | Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Benzamide Inhibitor | PDB:1LX6 | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [5] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IMLAHCEAVT214 PIRRTVTIED 224 VGNSAAFLCS234 DLSAGISGEV244 VHVDGGFSIA254 AMN
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ZAM or .ZAM2 or .ZAM3 or :3ZAM;style chemicals stick;color identity;select .A:93 or .A:94 or .A:95 or .A:100 or .A:146 or .A:154 or .A:155 or .A:156 or .A:159 or .A:163 or .A:191 or .A:206; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 6-Methyl-2(propane-1-sulfonyl)-2H-thieno[3,2-D][1,2,3]diazaborinin-1-OL | Ligand Info | |||||
| Structure Description | X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD AND THIENO-DIAZABORINE | PDB:1DFH | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [6] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IRTLAASGIK201 DFRKMLAHCE 211 AVTPIRRTVT221 IEDVGNSAAF231 LCSDLSAGIS241 GEVVHVDGGF251 SIAAMNE |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TDB or .TDB2 or .TDB3 or :3TDB;style chemicals stick;color identity;select .A:92 or .A:93 or .A:94 or .A:95 or .A:100 or .A:120 or .A:146 or .A:156 or .A:159 or .A:163 or .A:191 or .A:200 or .A:203 or .A:206; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: Diazaborine | Ligand Info | |||||
| Structure Description | X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD AND BENZO-DIAZABORINE | PDB:1DFG | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [6] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IRTLAASGIK201 DFRKMLAHCE 211 AVTPIRRTVT221 IEDVGNSAAF231 LCSDLSAGIS241 GEVVHVDGGF251 SIAAMNE |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NDT or .NDT2 or .NDT3 or :3NDT;style chemicals stick;color identity;select .A:92 or .A:93 or .A:94 or .A:95 or .A:97 or .A:100 or .A:120 or .A:146 or .A:156 or .A:159 or .A:163 or .A:191 or .A:199 or .A:200 or .A:203; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: (2S,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF ENOYL REDUCTASE INHIBITION BY TRICLOSAN | PDB:1QSG | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [1] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IRTLAASGIK201 DFRKMLAHCE 211 AVTPIRRTVT221 IEDVGNSAAF231 LCSDLSAGIS241 GEVVHVDGGF251 SIAAMNEL |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GLC or .GLC2 or .GLC3 or :3GLC;style chemicals stick;color identity;select .A:40 or .A:64 or .A:66 or .A:94 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: N-Methyl-N-[(3-Methyl-1-Benzofuran-2-Yl)methyl]-3-(7-Oxo-5,6,7,8-Tetrahydro-1,8-Naphthyridin-3-Yl)propanamide | Ligand Info | |||||
| Structure Description | Crystal Structure of E.coli Enoyl Reductase in Complex with NAD and AFN-1252 | PDB:4JQC | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [7] |
| PDB Sequence |
MGFLSGKRIL
10 VTGVASKLSI20 AYGIAQAMHR30 EGAELAFTYQ40 NDKLKGRVEE50 FAAQLGSDIV 60 LQCDVAEDAS70 IDTMFAELGK80 VWPKFDGFVH90 SIGFAPGDQL100 DGDYVNAVTR 110 EGFKIAHDIS120 SYSFVAMAKA130 CRSMLNPGSA140 LLTLSYLGAE150 RAIPNYNVMG 160 LAKASLEANV170 RYMANAMGPE180 GVRVNAISAG190 PIRTLAASGI200 KDFRKMLAHC 210 EAVTPIRRTV220 TIEDVGNSAA230 FLCSDLSAGI240 SGEVVHVDGG250 FSIAAMNE |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0WE or .0WE2 or .0WE3 or :30WE;style chemicals stick;color identity;select .A:93 or .A:94 or .A:95 or .A:96 or .A:97 or .A:100 or .A:146 or .A:153 or .A:154 or .A:155 or .A:156 or .A:159 or .A:163 or .A:191 or .A:195 or .A:196 or .A:198 or .A:199 or .A:200 or .A:203 or .A:206; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY93
4.102
PHE94
3.447
ALA95
2.842
PRO96
4.709
GLY97
3.541
LEU100
3.838
TYR146
3.603
ILE153
4.687
PRO154
3.785
ASN155
2.922
TYR156
2.707
|
|||||
| Ligand Name: 6-{(1e)-3-[3-(3-Methyl-1-Benzofuran-2-Yl)azetidin-1-Yl]-3-Oxoprop-1-En-1-Yl}-1,8-Naphthyridin-2(1h)-One | Ligand Info | |||||
| Structure Description | Crystal Structure of E.coli Enoyl Reductase in Complex with NAD and AEA16 | PDB:4JX8 | ||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [8] |
| PDB Sequence |
MGFLSGKRIL
10 VTGVASKLSI20 AYGIAQAMHR30 EGAELAFTYQ40 NDKLKGRVEE50 FAAQLGSDIV 60 LQCDVAEDAS70 IDTMFAELGK80 VWPKFDGFVH90 SIGFAPGDQL100 DGDYVNAVTR 110 EGFKIAHDIS120 SYSFVAMAKA130 CRSMLNPGSA140 LLTLSYLGAE150 RAIPNYNVMG 160 LAKASLEANV170 RYMANAMGPE180 GVRVNAISAG190 PIRTLAASGI200 KDFRKMLAHC 210 EAVTPIRRTV220 TIEDVGNSAA230 FLCSDLSAGI240 SGEVVHVDGG250 FSIAAMNE |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AE6 or .AE62 or .AE63 or :3AE6;style chemicals stick;color identity;select .A:93 or .A:94 or .A:95 or .A:96 or .A:97 or .A:100 or .A:146 or .A:153 or .A:154 or .A:155 or .A:156 or .A:159 or .A:163 or .A:191 or .A:195 or .A:196 or .A:198 or .A:199 or .A:200 or .A:206; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 1-Hydroxy-2,3,1-benzodiazaborinine-2-carboxamide | Ligand Info | |||||
| Structure Description | Crystal structure of E. coli FabI bound to the carbamoylated benzodiazaborine inhibitor 14b. | PDB:5CG1 | ||||
| Method | X-ray diffraction | Resolution | 2.07 Å | Mutation | No | [9] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IRTRKMLAHC210 EAVTPIRRTV 220 TIEDVGNSAA230 FLCSDLSAGI240 SGEVVHVDGG250 FSIAAMN
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BBN or .BBN2 or .BBN3 or :3BBN;style chemicals stick;color identity;select .A:92 or .A:93 or .A:94 or .A:120 or .A:146 or .A:156 or .A:159 or .A:163; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 1-Hydroxy-2,3,1-Benzodiazaborinine-2(1h)-Carbothioamide | Ligand Info | |||||
| Structure Description | Crystal structure of E. coli FabI bound to the thiocarbamoylated benzodiazaborine inhibitor 35b. | PDB:5CG2 | ||||
| Method | X-ray diffraction | Resolution | 2.11 Å | Mutation | No | [9] |
| PDB Sequence |
GFLSGKRILV
11 TGVASKLSIA21 YGIAQAMHRE31 GAELAFTYQN41 DKLKGRVEEF51 AAQLGSDIVL 61 QCDVAEDASI71 DTMFAELGKV81 WPKFDGFVHS91 IGFAPGDQLD101 GDYVNAVTRE 111 GFKIAHDISS121 YSFVAMAKAC131 RSMLNPGSAL141 LTLSYLGAER151 AIPNYNVMGL 161 AKASLEANVR171 YMANAMGPEG181 VRVNAISAGP191 IREAVTPIRR218 TVTIEDVGNS 228 AAFLCSDLSA238 GISGEVVHVD248 GGFSIAAMN
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CJ3 or .CJ32 or .CJ33 or :3CJ3;style chemicals stick;color identity;select .A:92 or .A:93 or .A:94 or .A:120 or .A:146 or .A:156 or .A:159 or .A:163; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis and mechanism of enoyl reductase inhibition by triclosan. J Mol Biol. 1999 Jul 23;290(4):859-65. | ||||
| REF 2 | Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK. J Med Chem. 2003 Apr 24;46(9):1627-35. | ||||
| REF 3 | 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. | ||||
| REF 4 | Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2241-4. | ||||
| REF 5 | Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). J Med Chem. 2002 Jul 18;45(15):3246-56. | ||||
| REF 6 | A mechanism of drug action revealed by structural studies of enoyl reductase. Science. 1996 Dec 20;274(5295):2107-10. | ||||
| REF 7 | Crystal Structure of E.coli Enoyl Reductase in Complex with NAD and AFN-1252 | ||||
| REF 8 | Crystal Structure of E.coli Enoyl Reductase in Complex with NAD and AEA16 | ||||
| REF 9 | Crystallographic insights into the structure-activity relationships of diazaborine enoyl-ACP reductase inhibitors. Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1521-30. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.