Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T52910 | Target Info | |||
| Target Name | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | ||||
| Synonyms | Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30 | ||||
| Target Type | Preclinical Target | ||||
| Gene Name | USP30 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Allylamine | Ligand Info | |||||
| Structure Description | Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution) | PDB:5OHK | ||||
| Method | X-ray diffraction | Resolution | 2.34 Å | Mutation | Yes | [1] |
| PDB Sequence |
KGLVPGLVNL
73 GNTCFMNSLL83 QGLSACPAFI93 RWLEEFTSQY103 SRQYLSLTLL121 HLLKALSCQE 131 VTDDEVLDAS141 CLLDVLRMYR151 WQISSFEEQD161 AHELFHVITS171 SLEDERDGSG 181 SHWKSQHPFH225 GRLTSNMVCK235 HCEHQSPVRF245 DTFDSLSLSI255 PAATWGHPLT 265 LDHCLHHFIS275 SESVRDVVCD285 NCTKRTTFVK310 QLKLGKLPQC320 LCIHLQRLSW 330 SSHGTPLKRH340 EHVQFNEDLS350 MDEYKYHSNA360 STYLFRLMAV441 VVHHGDMHSG 451 HFVTYRRSPP461 SSNQWLWVSD478 DTVRKASLQE488 VLSSSAYLLF498 YERV |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nat Struct Mol Biol. 2017 Nov;24(11):920-930. | ||||
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