Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T52489 | Target Info | |||
| Target Name | Rap guanine nucleotide exchange factor 3 (RAPGEF3) | ||||
| Synonyms | Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | RAPGEF3 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: [3H]cAMP | Ligand Info | |||||
| Structure Description | GEF regulatory domain | PDB:6H7E | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
ASTERVLRAG
59 RQLHRHLLAT69 CPNLIRDRKY79 HLRLYRQCCS89 GRELVDGILA99 LGHSRSQVVG 112 ICQVLLDEGA122 LCHVKHDWAF132 QDRDAQFYRF142 PGPEPEPVEE158 LAEAVALLSQ 168 RGPDALLTVA178 LRKPPGQRTD188 EELDLIFEEL198 LHIKAVAHLS208 NSVKRELAAV 218 LLFEPHSKAG228 TVLFSQGDKG238 TSWYIIWKGS248 VNVVTHGKGL258 VTTLHEGDDF 268 GQLALVNDAP278 RAATIILRED288 NCHFLRVDKQ298 DFNRIIK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | GEF regulatory domain | ||||
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