Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T51284 | Target Info | |||
| Target Name | Bacterial Pyridoxal phosphate biosynthetic pdxJ (Bact pdxJ) | ||||
| Synonyms | pdxJ; Pyridoxine 5'-phosphate synthase; PNP synthase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | Bact pdxJ | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 1-Deoxy-D-Xylulose-5-Phosphate | Ligand Info | |||||
| Structure Description | 1.96 A Crystal Structure of Pyridoxine 5'-Phosphate Synthase in Complex with 1-deoxy-D-xylulose phosphate | PDB:1M5W | ||||
| Method | X-ray diffraction | Resolution | 1.96 Å | Mutation | No | [1] |
| PDB Sequence |
AELLLGVNID
11 HIATLRNARG21 TAYPDPVQAA31 FIAEQAGADG41 ITVHLREDRR51 HITDRDVRIL 61 RQTLDTRMNL71 EMAVTEEMLA81 IAVETKPHFC91 CLVPEKRQEV101 TTEGGLDVAG 111 QRDKMRDACK121 RLADAGIQVS131 LFIDADEEQI141 KAAAEVGAPF151 IEIHTGCYAD 161 AKTDAEQAQE171 LARIAKAATF181 AASLGLKVNA191 GHGLTYHNVK201 AIAAIPEMHE 211 LNIGHAIIGR221 AVMTGLKDAV231 AEMKRLMLEA241 RG
|
|||||
|
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Pyridoxine-5'-Phosphate | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF PYRIDOXINE 5'-PHOSPHATE SYNTHASE IN COMPLEX WITH PYRIDOXINE 5'-PHOSPHATE AND INORGANIC PHOSPHATE | PDB:1HO4 | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [2] |
| PDB Sequence |
AELLLGVNID
11 HIATLRNARG21 TAYPDPVQAA31 FIAEQAGADG41 ITVHLREDRR51 HITDRDVRIL 61 RQTLDTRMNL71 EMAVTEEMLA81 IAVETKPHFC91 CLVPEKRQEV101 TTEGGLDVAG 111 QRDKMRDACK121 RLADAGIQVS131 LFIDADEEQI141 KAAAEVGAPF151 IEIHTGCYAD 161 AKTDAEQAQE171 LARIAKAATF181 AASLGLKVNA191 GHGLTYHNVK201 AIAAIPEMHE 211 LNIGHAIIGR221 AVMTGLKDAV231 AEMKRLMLEA241 RG
|
|||||
|
|
||||||
| Ligand Name: sn-Glycerol 3-phosphate | Ligand Info | |||||
| Structure Description | Enzyme-Substrate Complex of Pyridoxine 5'-Phosphate Synthase | PDB:1IXN | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [3] |
| PDB Sequence |
AELLLGVNID
11 HIATLRNARG21 TAYPDPVQAA31 FIAEQAGADG41 ITVHLREDRR51 HITDRDVRIL 61 RQTLDTRMNL71 EMAVTEEMLA81 IAVETKPHFC91 CLVPEKRQEV101 TTEGGLDVAG 111 QRDKMRDACK121 RLADAGIQVS131 LFIDADEEQI141 KAAAEVGAPF151 IEIHTGCYAD 161 AKTDAEQAQE171 LARIAKAATF181 AASLGLKVNA191 GHGLTYHNVK201 AIAAIPEMHE 211 LNIGHAIIGR221 AVMTGLKDAV231 AEMKRLMLEA241 RG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G3P or .G3P2 or .G3P3 or :3G3P;style chemicals stick;color identity;select .A:9 or .A:12 or .A:43 or .A:72 or .A:133 or .A:153 or .A:192 or .A:193 or .A:194 or .A:195 or .A:213 or .A:214 or .A:215 or .A:216 or .A:217; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate. Biochemistry. 2002 Oct 1;41(39):11649-57. | ||||
| REF 2 | Structural basis for the function of pyridoxine 5'-phosphate synthase. Structure. 2001 Mar 7;9(3):245-53. | ||||
| REF 3 | Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis. J Mol Biol. 2002 Aug 23;321(4):601-12. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.