Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T49755 | Target Info | |||
| Target Name | LDL receptor related protein-6 (LRP-6) | ||||
| Synonyms | Low-density lipoprotein receptor-related protein 6 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | LRP6 | ||||
| Biochemical Class | Low density lipoprotein receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: L-serine-O-phosphate | Ligand Info | |||||
| Structure Description | Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 e-motif | PDB:4NM7 | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
PPPPC
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| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 c-motif | PDB:4NM5 | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
PPPPR
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| Ligand Name: alpha-L-Fucose | Ligand Info | |||||
| Structure Description | The structure of a beta propeller domain in complex with peptide S | PDB:3SOV | ||||
| Method | X-ray diffraction | Resolution | 1.27 Å | Mutation | Yes | [2] |
| PDB Sequence |
APLLLYANRR
29 DLRLVDATNG39 KENATIVVGG49 LEDAAAVDFV59 FSHGLIYWSD69 VSEEAIKRTE 79 FNKTESVQNV89 VVSGLLSPDG99 LACDWLGEKL109 YWTDSETNRI119 EVSNLDGSLR 129 KVLFWQELDQ139 PRAIALDPSS149 GFMYWTDWGE159 VPKIERAGMD169 GSSRFIIINS 179 EIYWPNGLTL189 DYEEQKLYWA199 DAKLNFIHKS209 NLDGTNRQAV219 VKGSLPHPFA 229 LTLFEDILYW239 TDWSTHSILA249 CNKYTGEGLR259 EIHSDIFSPM269 DIHAFSQQRQ 279 PNATNPCGID289 NGGCSHLCLM299 SPVKPFYQCA309 CPTGVKLLEN319 GKTCKD |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife. 2014 Mar 18;3:e01998. | ||||
| REF 2 | Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6. Structure. 2011 Oct 12;19(10):1433-42. | ||||
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