Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T49526 | Target Info | |||
| Target Name | Voltage-gated potassium channel Kv7.1 (KCNQ1) | ||||
| Synonyms | Voltage-gated potassium channel subunit Kv7.1; Potassium voltage-gated channel subfamily KQT member 1; Kv7.1; KVLQT1; KQT-like 1; KCNQ1 channel; KCNA9; KCNA8; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; IKs producing slow voltage-gated potassium channel alpha subunit KvLQT1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | KCNQ1 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | Ligand Info | |||||
| Structure Description | structure of human KCNQ1-KCNE3-CaM complex with PIP2 | PDB:6V01 | ||||
| Method | Electron microscopy | Resolution | 3.90 Å | Mutation | No | [1] |
| PDB Sequence |
THVQGRVYNF
113 LERPTGWKCF123 VYHFAVFLIV133 LVCLIFSVLS143 TIEQYAALAT153 GTLFWMEIVL 163 VVFFGTEYVV173 RLWSAGCRSK183 YVGLWGRLRF193 ARKPISIIDL203 IVVVASMVVL 213 CVGSKSAIRG229 IRFLQILRML239 HVDRQGGTWR249 LLGSVVFIHR259 QELITTLYIG 269 FLGLIFSSYF279 VYLAEKDAVN289 ESGRVEFGSY299 ADALWWGVVT309 VTTIGYGDKV 319 PQTWVGKTIA329 SCFSVFAISF339 FALPAGILGS349 GFALKVQQKQ359 RQKHFNRQIP 369 AAASLIQTAW379 RCYAAENPLR507 EHHRATIKVI517 RRMQYFVAKK527 KFQQARKPYD 537 IEQYSQGHLN551 LMVRIKELQR561 R
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural Basis of Human KCNQ1 Modulation and Gating. Cell. 2020 Jan 23;180(2):340-347.e9. | ||||
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