Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T49327 | Target Info | |||
| Target Name | ATP-binding cassette transporter A4 (ABCA4) | ||||
| Synonyms | Stargardt disease protein; RmP; Retinal-specific ATP-binding cassette transporter; RIM protein; RIM ABC transporter; ATP-binding cassette sub-family A member 4; ABCA4 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ABCA4 | ||||
| Biochemical Class | ABC transporter | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Adenosine triphosphate | Ligand Info | |||||
| Structure Description | Structure of ATP-bound human ABCA4 | PDB:7LKZ | ||||
| Method | Electron microscopy | Resolution | 3.27 Å | Mutation | Yes | [1] |
| PDB Sequence |
FVRQIQLLLW
12 KNWTLRKRQK22 IRFVVELVWP32 LSLFLVLIWL42 RNANPLYSHH52 ECHFPNKAMP 62 SAGMLPWLQG72 IFCNVNNPCF82 QSPTPGESPG92 IVSNYNNSIL102 ARVYRDFQEL 112 LMNAPESQHL122 GRIWTELHIL132 SQFMDWGGIL277 SDMSPRIQEF287 IHRPSMQDLL 297 WVTRPLGPET311 FTKLMGILSD321 LLCGYPEGGG331 WYEDNNYKAF348 LGYDRRTTSF 369 CNALIQSLES379 NPLTKIAWRA389 AKPLLMGKIL399 YTPDSPAARR409 ILKNANSTFE 419 ELEHVRKLVK429 AWEEVGPQIW439 YFFDNSTQMN449 MIRDTLGNPT459 VKDFLNRQLD 498 WRDIFNITDR508 TLRLVNQYLE518 CLVLDKFESY528 NDETQLTQRA538 LSLLEENMFW 548 AGVVFPDMYP558 WTSSLPPHVK568 YKIRMDIDVV578 EKTNKIKDRY588 WDSGPRADPV 598 EDFRYIWGGF608 AYLQDMVEQG618 ITRSQVQAEA628 PVGIYLQQMP638 YPCFVDDSFM 648 IILNRCFPIF658 MVLAWIYSVS668 MTVKSIVLEK678 ELRLKETLKN688 QGVSNAVIWC 698 TWFLDSFSIM708 SMSIFLLTIF718 IMHGRILHYS728 DPFILFLFLL738 AFSTATIMLC 748 FLLSTFFSKA758 SLAAACSGVI768 YFTLYLPHIL778 CFAWQDRMTA788 ELKKAVSLLS 798 PVAFGFGTEY808 LVRFEEQGLG818 LQWSNIGNSP828 TEGDEFSFLL838 SMQMMLLDAA 848 VYGLLAWYLD858 QVFPGDYGTP868 LPWYFLLQES878 YWLHDSFFER920 EHPGWVPGVC 930 VKNLVKIFEP940 CGRPAVDRLN950 ITFYENQITA960 FLGHNGAGKT970 TTLSILTGLL 980 PPTSGTVLVG990 GRDIETSLDA1000 VRQSLGMCPQ1010 HNILFHHLTV1020 AEHMLFYAQL 1030 KGKSQEEAQL1040 EMEAMLEDTG1050 LHHKRNEEAQ1060 DLSGGMQRKL1070 SVAIAFVGDA 1080 KVVILDQPTS1090 GVDPYSRRSI1100 WDLLLKYRSG1110 RTIIMSTHHM1120 DEADLLGDRI 1130 AIIAQGRLYC1140 SGTPLFLKNC1150 FGTGLYLTLV1160 RKMKQVLDGD1204 VNELMDVVLH 1214 HVPEAKLVEC1224 IGQELIFLLP1234 NKNFKHRAYA1244 SLFRELEETL1254 ADLGLSSFGI 1264 SDTPLEEIFL1274 KVTEDSPQLN1345 TGTQLVLQHV1355 QALLVKRFQH1365 TIRSHKDFLA 1375 QIVLPATFVF1385 LALMLSIVIP1395 PFGEYPALTL1405 HPWIYGQQYT1415 FFSMDEPGSE 1425 QFTVLADVLL1435 NKPGFGNRCL1445 KEGWLPEYPC1455 GNSTPWKTPS1465 VSPNITQLFQ 1475 KQKWTQVNPS1485 PSCRCSTREK1495 LTMLPECPEG1505 AGGLPPPQRT1515 QRSTEILQDL 1525 TDRNISDFLV1535 KTYPALIRSS1545 LKSKFWVNEQ1555 RYGGISIGGK1565 LPVVPITGEA 1575 LVGFLSDLGR1585 IMNVSGGPIT1595 REASKEIPDF1605 LKHLETEDNI1615 KVWFNNKGWH 1625 ALVSFLNVAH1635 NAILRASLPK1645 DRSPEEYGIT1655 VISQPLNLTK1665 EQLSEITVLT 1675 TSVDAVVAIC1685 VIFSMSFVPA1695 SFVLYLIQER1705 VNKSKHLQFI1715 SGVSPTTYWV 1725 TNFLWDIMNY1735 SVSAGLVVGI1745 FIGFQKKAYT1755 SPENLPALVA1765 LLLLYGWAVI 1775 PMMYPASFLF1785 DVPSTAYVAL1795 SCANLFIGIN1805 SSAITFILEL1815 FENNRTLLRF 1825 NAVLRKLLIV1835 FPHFCLGRGL1845 IDLALSQAVT1855 DVYARFGEEH1865 SANPFHWDLI 1875 GKNLFAMVVE1885 GVVYFLLTLL1895 VQRHFFLDED1918 DDVAEERQRI1928 ITGGNKTDIL 1938 RLHELTKIYP1948 GTSSPAVDRL1958 CVGVRPGECF1968 GLLGVNGAGK1978 TTTFKMLTGD 1988 TTVTSGDATV1998 AGKSILTNIS2008 EVHQNMGYCP2018 QFDAIDELLT2028 GREHLYLYAR 2038 LRGVPAEEIE2048 KVANWSIKSL2058 GLTVYADCLA2068 GTYSGGNKRK2078 LSTAIALIGC 2088 PPLVLLDQPT2098 TGMDPQARRM2108 LWNVIVSIIR2118 EGRAVVLTSH2128 SMEECEALCT 2138 RLAIMVKGAF2148 RCMGTIQHLK2158 SKFGDGYIVT2168 MKIKSLLPDL2182 NPVEQFFQGN 2192 FPGSVQRERH2202 YNMLQFQVSS2212 SSLARIFQLL2222 LSHKDSLLIE2232 EYSVTQTTLD 2242 QVFVNFAKQQ2252
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PHE938
3.328
ARG943
4.590
ALA945
3.425
GLY963
4.904
HIS964
4.173
ASN965
3.151
GLY966
3.226
ALA967
4.051
GLY968
3.247
LYS969
2.961
THR970
3.123
THR971
3.515
GLN1010
3.165
LYS1054
2.854
GLU1057
3.752
ASP1061
3.284
LEU1062
4.878
SER1063
3.396
GLY1064
3.218
GLY1065
3.292
MET1066
4.701
GLN1087
4.137
GLY1091
4.529
HIS1118
3.131
TYR1947
3.565
THR1950
4.527
ALA1954
4.060
VAL1973
4.509
ASN1974
2.674
GLY1975
3.069
ALA1976
4.114
GLY1977
3.385
LYS1978
2.887
THR1979
3.156
THR1980
2.931
GLN2019
3.828
TYR2063
4.068
GLY2069
4.768
THR2070
2.696
TYR2071
4.416
SER2072
3.280
GLY2073
2.709
GLY2074
2.947
ASN2075
4.989
GLN2096
3.665
GLY2100
4.158
HIS2128
3.820
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Structure of ATP-free human ABCA4 | PDB:7LKP | ||||
| Method | Electron microscopy | Resolution | 3.27 Å | Mutation | No | [1] |
| PDB Sequence |
FVRQIQLLLW
12 KNWTLRKRQK22 IRFVVELVWP32 LSLFLVLIWL42 RNANPLYSHH52 ECHFPNKAMP 62 SAGMLPWLQG72 IFCNVNNPCF82 QSPTPGESPG92 IVSNYNNSIL102 ARVYRDFQEL 112 LMNAPESQHL122 GRIWTELHIL132 SQFMDSWGGI276 LSDMSPRIQE286 FIHRPSMQDL 296 LWVTRPLMQN306 GGPETFTKLM316 GILSDLLCGY326 PEGGGSRVLS336 FNWYEDNNYK 346 AFLGIDSTRK356 DPIYSYDRRT366 TSFCNALIQS376 LESNPLTKIA386 WRAAKPLLMG 396 KILYTPDSPA406 ARRILKNANS416 TFEELEHVRK426 LVKAWEEVGP436 QIWYFFDNST 446 QMNMIRDTLG456 NPTVKDFLNR466 QLITAEAILN486 FLYKGPRESQ496 FDWRDIFNIT 506 DRTLRLVNQY516 LECLVLDKFE526 SYNDETQLTQ536 RALSLLEENM546 FWAGVVFPDM 556 YPWTSSLPPH566 VKYKIRMDID576 VVEKTNKIKD586 RYWDSGPRAD596 PVEDFRYIWG 606 GFAYLQDMVE616 QGITRSQVQA626 EAPVGIYLQQ636 MPYPCFVDDS646 FMIILNRCFP 656 IFMVLAWIYS666 VSMTVKSIVL676 EKELRLKETL686 KNQGVSNAVI696 WCTWFLDSFS 706 IMSMSIFLLT716 IFIMHGRILH726 YSDPFILFLF736 LLAFSTATIM746 LCFLLSTFFS 756 KASLAAACSG766 VIYFTLYLPH776 ILCFAWQDRM786 TAELKKAVSL796 LSPVAFGFGT 806 EYLVRFEEQG816 LGLQWSNIGN826 SPTEGDEFSF836 LLSMQMMLLD846 AAVYGLLAWY 856 LDQVFPGDYG866 TPLPWYFSFF918 EREHPGWVPG928 VCVKNLVKID947 RLNITFYENQ 957 ITAFLGHNGA967 GKTTTLSILT977 GLLPPTSGTV987 LVGGRDIETS997 LDAVRQSLGM 1007 CPQHNILFHH1017 LTVAEHMLFY1027 AQLKGKSQEE1037 AQLEMEAMLE1047 DTGLHHKRNE 1057 EAQDLSGGMQ1067 RKLSVAIAFV1077 GDAKVVILDE1087 PTSGVDPYSR1097 RSIWDLLLKY 1107 RSGRTIIMST1117 HHMDEADLLG1127 DRIAIIAQGR1137 LYCSGTPLFL1147 KNCFGTGLYL 1157 TLVRKLDGDV1205 NELMDVVLHH1215 VPEAKLVECI1225 GQELIFLLPN1235 KNFKHRAYAS 1245 LFRELEETLA1255 DLGLSSFGIS1265 DTPLEEIFLK1275 VTPGPQLNTG1347 TQLVLQHVQA 1357 LLVKRFQHTI1367 RSHKDFLAQI1377 VLPATFVFLA1387 LMLSIVIPPF1397 GEYPALTLHP 1407 WIYGQQYTFF1417 SMDEPGSEQF1427 TVLADVLLNK1437 PGFGNRCLKE1447 GWLPEYPCGN 1457 STPWKTPSVS1467 PNITQLFQKQ1477 KWTQVNPSPS1487 CRCSTREKLT1497 MLPECPEGAG 1507 GLPPPQRTQR1517 STEILQDLTD1527 RNISDFLVKT1537 YPALIRSSLK1547 SKFWVNEQRY 1557 GGISIGGKLP1567 VVPITGEALV1577 GFLSDLGRIM1587 NVSGGPITRE1597 ASKEIPDFLK 1607 HLETEDNIKV1617 WFNNKGWHAL1627 VSFLNVAHNA1637 ILRASLPKDR1647 SPEEYGITVI 1657 SQPLNLTKEQ1667 LSEITVLTTS1677 VDAVVAICVI1687 FSMSFVPASF1697 VLYLIQERVN 1707 KSKHLQFISG1717 VSPTTYWVTN1727 FLWDIMNYSV1737 SAGLVVGIFI1747 GFQKKAYTSP 1757 ENLPALVALL1767 LLYGWAVIPM1777 MYPASFLFDV1787 PSTAYVALSC1797 ANLFIGINSS 1807 AITFILELFE1817 NNRTLLRFNA1827 VLRKLLIVFP1837 HFCLGRGLID1847 LALSQAVTDV 1857 YARFGEEHSA1867 NPFHWDLIGK1877 NLFAMVVEGV1887 VYFLLTLLVQ1897 RHFKEPIVDE 1917 DDDVAEERQR1927 IITGGNKTDI1937 LRLHELTKIY1947 PGTSSPAVDR1957 LCVGVRPGEC 1967 FGLLGVNGAG1977 KTTTFKMLTG1987 DTTVTSGDAT1997 VAGKSILTNI2007 SEVHQNMGYC 2017 PQFDAIDELL2027 TGREHLYLYA2037 RLRGVPAEEI2047 EKVANWSIKS2057 LGLTVYADCL 2067 AGTYSGGNKR2077 KLSTAIALIG2087 CPPLVLLDEP2097 TTGMDPQARR2107 MLWNVIVSII 2117 REGRAVVLTS2127 HSMEECEALC2137 TRLAIMVKGA2147 FRCMGTIQHL2157 KSKFGDGYIV 2167 TMKIKLLPDL2182 NPVEQFFQGN2192 FPGSVQRERH2202 YNMLQFQVSS2212 SSLARIFQLL 2222 LSHKDSLLIE2232 EYSVTQTTLD2242 QVFVNFAKQQ2252 T
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LEU11
3.387
TRP12
2.927
TRP15
2.320
THR16
4.645
LYS19
4.244
ILE23
3.997
VAL27
4.076
TRP31
3.955
LEU661
4.412
ILE664
2.869
TYR665
4.676
LEU702
3.569
SER706
3.199
LEU760
3.994
ALA763
3.676
CYS764
4.740
VAL767
3.614
LEU1359
4.572
VAL1360
3.945
PHE1363
2.241
THR1366
3.994
ILE1367
3.381
SER1369
3.419
HIS1370
3.118
LYS1371
2.764
PHE1373
2.454
GLN1376
4.804
ILE1377
4.375
PHE1688
4.164
PHE1692
4.430
LEU1699
2.646
TRP1730
3.882
MET1733
3.250
ASN1734
3.706
VAL1737
4.248
PRO1780
3.828
PHE1783
3.800
LEU1784
3.165
PRO1788
3.882
SER1789
2.625
THR1790
3.604
TYR1792
2.561
VAL1793
1.978
ALA1794
4.829
SER1796
1.914
CYS1797
3.715
LEU1892
3.989
VAL1896
3.558
PHE1900
3.613
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| Ligand Name: [(2S)-3-[2-[(E)-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenylidene]amino]ethoxy-oxidanyl-phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxy-propyl] (Z)-octadec-9-enoate | Ligand Info | |||||
| Structure Description | Human ABCA4 structure in complex with N-ret-PE | PDB:7M1Q | ||||
| Method | Electron microscopy | Resolution | 2.92 Å | Mutation | No | [2] |
| PDB Sequence |
FVRQIQLLLW
12 KNWTLRKRQK22 IRFVVELVWP32 LSLFLVLIWL42 RNANPLYSHH52 ECHFPNKAMP 62 SAGMLPWLQG72 IFCNVNNPCF82 QSPTPGESPG92 IVSNYNNSIL102 ARVYRDFQEL 112 LMNAPESQHL122 GRIWTELHIL132 SQFMDTLRTH142 PERIAGRGIR152 IRDILKDEET 162 LTLFLIKNIG172 LSDSVVYLLI182 NSQVRPELQW239 IEDTLYANVD249 FFKLFRVLPT 259 LLDSRSQGIN269 LRSWGGILSD279 MSPRIQEFIH289 RPSMQDLLWV299 TRPLMQNGGP 309 ETFTKLMGIL319 SDLLCGYPEG329 GGSRVLSFNW339 YEDNNYKAFL349 GIDSTRKDPI 359 YSYDRRTTSF369 CNALIQSLES379 NPLTKIAWRA389 AKPLLMGKIL399 YTPDSPAARR 409 ILKNANSTFE419 ELEHVRKLVK429 AWEEVGPQIW439 YFFDNSTQMN449 MIRDTLGNPT 459 VKDFLNRQLG469 EEGITAEAIL479 NFLYKGPRES489 QADDMANFDW499 RDIFNITDRT 509 LRLVNQYLEC519 LVLDKFESYN529 DETQLTQRAL539 SLLEENMFWA549 GVVFPDMYPW 559 TSSLPPHVKY569 KIRMDIDVVE579 KTNKIKDRYW589 DSGPRADPVE599 DFRYIWGGFA 609 YLQDMVEQGI619 TRSQVQAEAP629 VGIYLQQMPY639 PCFVDDSFMI649 ILNRCFPIFM 659 VLAWIYSVSM669 TVKSIVLEKE679 LRLKETLKNQ689 GVSNAVIWCT699 WFLDSFSIMS 709 MSIFLLTIFI719 MHGRILHYSD729 PFILFLFLLA739 FSTATIMLCF749 LLSTFFSKAS 759 LAAACSGVIY769 FTLYLPHILC779 FAWQDRMTAE789 LKKAVSLLSP799 VAFGFGTEYL 809 VRFEEQGLGL819 QWSNIGNSPT829 EGDEFSFLLS839 MQMMLLDAAV849 YGLLAWYLDQ 859 VFPGDYGTPL869 PWYFLNITFY954 ENQITAFLGH964 NGAGKTTTLS974 ILTGLLPPTS 984 GTVLVGGRDI994 ETSLDAVRQS1004 LGMCPQHNIL1014 FHHLTVAEHM1024 LFYAQLKGKS 1034 QEEAQLEMEA1044 MLEDTGLHHK1054 RNEEAQDLSG1064 GMQRKLSVAI1074 AFVGDAKVVI 1084 LDEPTSGVDP1094 YSRRSIWDLL1104 LKYRSGRTII1114 MSTHHMDEAD1124 LLGDRIAIIA 1134 QGRLYCSGTP1144 LFLKNCGLYL1157 TLLDGDVNEL1208 MDVVLHHVPE1223 CIGQELIFKN 1237 FKHRAYASLF1247 RELEETLADL1257 GLSSFGISDT1267 PLEEIFLKVT1277 GPQLNTGTQL 1350 VLQHVQALLV1360 KRFQHTIRSH1370 KDFLAQIVLP1380 ATFVFLALML1390 SIVIPPFGEY 1400 PALTLHPWIY1410 GQQYTFFSMD1420 EPGSEQFTVL1430 ADVLLNKPGF1440 GNRCLKEGWL 1450 PEYPCGNSTP1460 WKTPSVSPNI1470 TQLFQKQKWT1480 QVNPSPSCRC1490 STREKLTMLP 1500 ECPEGAGGLP1510 PPQRTQRSTE1520 ILQDLTDRNI1530 SDFLVKTYPA1540 LIRSSLKSKF 1550 WVNEQRYGGI1560 SIGGKLPVVP1570 ITGEALVGFL1580 SDLGRIMNVS1590 GGPITREASK 1600 EIPDFLKHLE1610 TEDNIKVWFN1620 NKGWHALVSF1630 LNVAHNAILR1640 ASLPKDRSPE 1650 EYGITVISQP1660 LNLTKEQLSE1670 ITVLTTSVDA1680 VVAICVIFSM1690 SFVPASFVLY 1700 LIQERVNKSK1710 HLQFISGVSP1720 TTYWVTNFLW1730 DIMNYSVSAG1740 LVVGIFIGFQ 1750 KKAYTSPENL1760 PALVALLLLY1770 GWAVIPMMYP1780 ASFLFDVPST1790 AYVALSCANL 1800 FIGINSSAIT1810 FILELFENNR1820 TLLRFNAVLR1830 KLLIVFPHFC1840 LGRGLIDLAL 1850 SQAVTDVYAR1860 FGEEHSANPF1870 HWDLIGKNLF1880 AMVVEGVVYF1890 LLTLLVQRVR 1963 PGECFGLLGV1973 NGAGKTTTFK1983 MLTGDTTVTS1993 GDATVAGKSI2003 LTNISEVHQN 2013 MGYCPQFDAI2023 DELLTGREHL2033 YLYARLRGVP2043 AEEIEKVANW2053 SIKSLGLTVY 2063 ADCLAGTYSG2073 GNKRKLSTAI2083 ALIGCPPLVL2093 LDEPTTGMDP2103 QARRMLWNVI 2113 VSIIREGRAV2123 VLTSHSMEEC2133 EALCTRLAIT2153 IQHLKSKFGD2163 GYIVTMLLPD 2181 LNPVEQFFQG2191 NFRHYNMLQF2208 QVARIFQLLL2223 SHKDSLYSVT2237 QTTLDQVFVN 2247 F
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HZL or .HZL2 or .HZL3 or :3HZL;style chemicals stick;color identity;select .A:41 or .A:42 or .A:45 or .A:46 or .A:339 or .A:340 or .A:341 or .A:343 or .A:345 or .A:348 or .A:349 or .A:587 or .A:588 or .A:649 or .A:650 or .A:653 or .A:654 or .A:1394 or .A:1395 or .A:1397 or .A:1550 or .A:1673 or .A:1674 or .A:1677 or .A:1678 or .A:1681 or .A:1811 or .A:1812 or .A:1815; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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TRP41
4.377
LEU42
3.795
ALA45
4.497
ASN46
3.985
TRP339
4.068
TYR340
3.339
GLU341
4.230
ASN343
4.650
TYR345
3.574
PHE348
4.097
LEU349
4.280
ARG587
2.744
TYR588
3.772
ILE649
3.537
ILE650
4.017
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine | Ligand Info | |||||
| Structure Description | Structure of ATP-bound human ABCA4 | PDB:7LKZ | ||||
| Method | Electron microscopy | Resolution | 3.27 Å | Mutation | Yes | [1] |
| PDB Sequence |
FVRQIQLLLW
12 KNWTLRKRQK22 IRFVVELVWP32 LSLFLVLIWL42 RNANPLYSHH52 ECHFPNKAMP 62 SAGMLPWLQG72 IFCNVNNPCF82 QSPTPGESPG92 IVSNYNNSIL102 ARVYRDFQEL 112 LMNAPESQHL122 GRIWTELHIL132 SQFMDWGGIL277 SDMSPRIQEF287 IHRPSMQDLL 297 WVTRPLGPET311 FTKLMGILSD321 LLCGYPEGGG331 WYEDNNYKAF348 LGYDRRTTSF 369 CNALIQSLES379 NPLTKIAWRA389 AKPLLMGKIL399 YTPDSPAARR409 ILKNANSTFE 419 ELEHVRKLVK429 AWEEVGPQIW439 YFFDNSTQMN449 MIRDTLGNPT459 VKDFLNRQLD 498 WRDIFNITDR508 TLRLVNQYLE518 CLVLDKFESY528 NDETQLTQRA538 LSLLEENMFW 548 AGVVFPDMYP558 WTSSLPPHVK568 YKIRMDIDVV578 EKTNKIKDRY588 WDSGPRADPV 598 EDFRYIWGGF608 AYLQDMVEQG618 ITRSQVQAEA628 PVGIYLQQMP638 YPCFVDDSFM 648 IILNRCFPIF658 MVLAWIYSVS668 MTVKSIVLEK678 ELRLKETLKN688 QGVSNAVIWC 698 TWFLDSFSIM708 SMSIFLLTIF718 IMHGRILHYS728 DPFILFLFLL738 AFSTATIMLC 748 FLLSTFFSKA758 SLAAACSGVI768 YFTLYLPHIL778 CFAWQDRMTA788 ELKKAVSLLS 798 PVAFGFGTEY808 LVRFEEQGLG818 LQWSNIGNSP828 TEGDEFSFLL838 SMQMMLLDAA 848 VYGLLAWYLD858 QVFPGDYGTP868 LPWYFLLQES878 YWLHDSFFER920 EHPGWVPGVC 930 VKNLVKIFEP940 CGRPAVDRLN950 ITFYENQITA960 FLGHNGAGKT970 TTLSILTGLL 980 PPTSGTVLVG990 GRDIETSLDA1000 VRQSLGMCPQ1010 HNILFHHLTV1020 AEHMLFYAQL 1030 KGKSQEEAQL1040 EMEAMLEDTG1050 LHHKRNEEAQ1060 DLSGGMQRKL1070 SVAIAFVGDA 1080 KVVILDQPTS1090 GVDPYSRRSI1100 WDLLLKYRSG1110 RTIIMSTHHM1120 DEADLLGDRI 1130 AIIAQGRLYC1140 SGTPLFLKNC1150 FGTGLYLTLV1160 RKMKQVLDGD1204 VNELMDVVLH 1214 HVPEAKLVEC1224 IGQELIFLLP1234 NKNFKHRAYA1244 SLFRELEETL1254 ADLGLSSFGI 1264 SDTPLEEIFL1274 KVTEDSPQLN1345 TGTQLVLQHV1355 QALLVKRFQH1365 TIRSHKDFLA 1375 QIVLPATFVF1385 LALMLSIVIP1395 PFGEYPALTL1405 HPWIYGQQYT1415 FFSMDEPGSE 1425 QFTVLADVLL1435 NKPGFGNRCL1445 KEGWLPEYPC1455 GNSTPWKTPS1465 VSPNITQLFQ 1475 KQKWTQVNPS1485 PSCRCSTREK1495 LTMLPECPEG1505 AGGLPPPQRT1515 QRSTEILQDL 1525 TDRNISDFLV1535 KTYPALIRSS1545 LKSKFWVNEQ1555 RYGGISIGGK1565 LPVVPITGEA 1575 LVGFLSDLGR1585 IMNVSGGPIT1595 REASKEIPDF1605 LKHLETEDNI1615 KVWFNNKGWH 1625 ALVSFLNVAH1635 NAILRASLPK1645 DRSPEEYGIT1655 VISQPLNLTK1665 EQLSEITVLT 1675 TSVDAVVAIC1685 VIFSMSFVPA1695 SFVLYLIQER1705 VNKSKHLQFI1715 SGVSPTTYWV 1725 TNFLWDIMNY1735 SVSAGLVVGI1745 FIGFQKKAYT1755 SPENLPALVA1765 LLLLYGWAVI 1775 PMMYPASFLF1785 DVPSTAYVAL1795 SCANLFIGIN1805 SSAITFILEL1815 FENNRTLLRF 1825 NAVLRKLLIV1835 FPHFCLGRGL1845 IDLALSQAVT1855 DVYARFGEEH1865 SANPFHWDLI 1875 GKNLFAMVVE1885 GVVYFLLTLL1895 VQRHFFLDED1918 DDVAEERQRI1928 ITGGNKTDIL 1938 RLHELTKIYP1948 GTSSPAVDRL1958 CVGVRPGECF1968 GLLGVNGAGK1978 TTTFKMLTGD 1988 TTVTSGDATV1998 AGKSILTNIS2008 EVHQNMGYCP2018 QFDAIDELLT2028 GREHLYLYAR 2038 LRGVPAEEIE2048 KVANWSIKSL2058 GLTVYADCLA2068 GTYSGGNKRK2078 LSTAIALIGC 2088 PPLVLLDQPT2098 TGMDPQARRM2108 LWNVIVSIIR2118 EGRAVVLTSH2128 SMEECEALCT 2138 RLAIMVKGAF2148 RCMGTIQHLK2158 SKFGDGYIVT2168 MKIKSLLPDL2182 NPVEQFFQGN 2192 FPGSVQRERH2202 YNMLQFQVSS2212 SSLARIFQLL2222 LSHKDSLLIE2232 EYSVTQTTLD 2242 QVFVNFAKQQ2252
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6OU or .6OU2 or .6OU3 or :36OU;style chemicals stick;color identity;select .A:21 or .A:23 or .A:24 or .A:27 or .A:583 or .A:587 or .A:653 or .A:665 or .A:669 or .A:753 or .A:754 or .A:755 or .A:756 or .A:757 or .A:760 or .A:764 or .A:777 or .A:778 or .A:780 or .A:781 or .A:782 or .A:783 or .A:784 or .A:861 or .A:1371 or .A:1374 or .A:1375 or .A:1379 or .A:1390 or .A:1391 or .A:1393 or .A:1394 or .A:1395 or .A:1396 or .A:1670 or .A:1673 or .A:1674 or .A:1677 or .A:1678 or .A:1681 or .A:1784 or .A:1785 or .A:1786 or .A:1787 or .A:1790 or .A:1794 or .A:1795 or .A:1798; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLN21
3.951
ILE23
3.933
ARG24
3.657
VAL27
4.025
LYS583
4.767
ARG587
4.524
ARG653
3.202
TYR665
3.095
MET669
4.513
THR753
4.159
PHE754
2.807
PHE755
3.297
SER756
2.675
LYS757
4.273
LEU760
3.605
CYS764
4.422
ILE777
3.744
LEU778
3.825
PHE780
3.183
ALA781
2.732
TRP782
4.223
GLN783
3.100
ASP784
4.778
PHE861
4.382
LYS1371
3.798
LEU1374
4.587
ALA1375
4.096
LEU1379
4.182
LEU1390
3.503
SER1391
3.563
VAL1393
4.111
ILE1394
3.776
PRO1395
4.504
PRO1396
4.231
GLU1670
3.316
VAL1673
4.003
LEU1674
3.753
SER1677
3.265
VAL1678
3.794
VAL1681
4.555
LEU1784
3.242
PHE1785
3.402
ASP1786
2.601
VAL1787
3.574
THR1790
4.324
ALA1794
3.688
LEU1795
4.478
ALA1798
4.779
|
|||||
| Ligand Name: Digitonin | Ligand Info | |||||
| Structure Description | Structure of ATP-free human ABCA4 | PDB:7LKP | ||||
| Method | Electron microscopy | Resolution | 3.27 Å | Mutation | No | [1] |
| PDB Sequence |
FVRQIQLLLW
12 KNWTLRKRQK22 IRFVVELVWP32 LSLFLVLIWL42 RNANPLYSHH52 ECHFPNKAMP 62 SAGMLPWLQG72 IFCNVNNPCF82 QSPTPGESPG92 IVSNYNNSIL102 ARVYRDFQEL 112 LMNAPESQHL122 GRIWTELHIL132 SQFMDSWGGI276 LSDMSPRIQE286 FIHRPSMQDL 296 LWVTRPLMQN306 GGPETFTKLM316 GILSDLLCGY326 PEGGGSRVLS336 FNWYEDNNYK 346 AFLGIDSTRK356 DPIYSYDRRT366 TSFCNALIQS376 LESNPLTKIA386 WRAAKPLLMG 396 KILYTPDSPA406 ARRILKNANS416 TFEELEHVRK426 LVKAWEEVGP436 QIWYFFDNST 446 QMNMIRDTLG456 NPTVKDFLNR466 QLITAEAILN486 FLYKGPRESQ496 FDWRDIFNIT 506 DRTLRLVNQY516 LECLVLDKFE526 SYNDETQLTQ536 RALSLLEENM546 FWAGVVFPDM 556 YPWTSSLPPH566 VKYKIRMDID576 VVEKTNKIKD586 RYWDSGPRAD596 PVEDFRYIWG 606 GFAYLQDMVE616 QGITRSQVQA626 EAPVGIYLQQ636 MPYPCFVDDS646 FMIILNRCFP 656 IFMVLAWIYS666 VSMTVKSIVL676 EKELRLKETL686 KNQGVSNAVI696 WCTWFLDSFS 706 IMSMSIFLLT716 IFIMHGRILH726 YSDPFILFLF736 LLAFSTATIM746 LCFLLSTFFS 756 KASLAAACSG766 VIYFTLYLPH776 ILCFAWQDRM786 TAELKKAVSL796 LSPVAFGFGT 806 EYLVRFEEQG816 LGLQWSNIGN826 SPTEGDEFSF836 LLSMQMMLLD846 AAVYGLLAWY 856 LDQVFPGDYG866 TPLPWYFSFF918 EREHPGWVPG928 VCVKNLVKID947 RLNITFYENQ 957 ITAFLGHNGA967 GKTTTLSILT977 GLLPPTSGTV987 LVGGRDIETS997 LDAVRQSLGM 1007 CPQHNILFHH1017 LTVAEHMLFY1027 AQLKGKSQEE1037 AQLEMEAMLE1047 DTGLHHKRNE 1057 EAQDLSGGMQ1067 RKLSVAIAFV1077 GDAKVVILDE1087 PTSGVDPYSR1097 RSIWDLLLKY 1107 RSGRTIIMST1117 HHMDEADLLG1127 DRIAIIAQGR1137 LYCSGTPLFL1147 KNCFGTGLYL 1157 TLVRKLDGDV1205 NELMDVVLHH1215 VPEAKLVECI1225 GQELIFLLPN1235 KNFKHRAYAS 1245 LFRELEETLA1255 DLGLSSFGIS1265 DTPLEEIFLK1275 VTPGPQLNTG1347 TQLVLQHVQA 1357 LLVKRFQHTI1367 RSHKDFLAQI1377 VLPATFVFLA1387 LMLSIVIPPF1397 GEYPALTLHP 1407 WIYGQQYTFF1417 SMDEPGSEQF1427 TVLADVLLNK1437 PGFGNRCLKE1447 GWLPEYPCGN 1457 STPWKTPSVS1467 PNITQLFQKQ1477 KWTQVNPSPS1487 CRCSTREKLT1497 MLPECPEGAG 1507 GLPPPQRTQR1517 STEILQDLTD1527 RNISDFLVKT1537 YPALIRSSLK1547 SKFWVNEQRY 1557 GGISIGGKLP1567 VVPITGEALV1577 GFLSDLGRIM1587 NVSGGPITRE1597 ASKEIPDFLK 1607 HLETEDNIKV1617 WFNNKGWHAL1627 VSFLNVAHNA1637 ILRASLPKDR1647 SPEEYGITVI 1657 SQPLNLTKEQ1667 LSEITVLTTS1677 VDAVVAICVI1687 FSMSFVPASF1697 VLYLIQERVN 1707 KSKHLQFISG1717 VSPTTYWVTN1727 FLWDIMNYSV1737 SAGLVVGIFI1747 GFQKKAYTSP 1757 ENLPALVALL1767 LLYGWAVIPM1777 MYPASFLFDV1787 PSTAYVALSC1797 ANLFIGINSS 1807 AITFILELFE1817 NNRTLLRFNA1827 VLRKLLIVFP1837 HFCLGRGLID1847 LALSQAVTDV 1857 YARFGEEHSA1867 NPFHWDLIGK1877 NLFAMVVEGV1887 VYFLLTLLVQ1897 RHFKEPIVDE 1917 DDDVAEERQR1927 IITGGNKTDI1937 LRLHELTKIY1947 PGTSSPAVDR1957 LCVGVRPGEC 1967 FGLLGVNGAG1977 KTTTFKMLTG1987 DTTVTSGDAT1997 VAGKSILTNI2007 SEVHQNMGYC 2017 PQFDAIDELL2027 TGREHLYLYA2037 RLRGVPAEEI2047 EKVANWSIKS2057 LGLTVYADCL 2067 AGTYSGGNKR2077 KLSTAIALIG2087 CPPLVLLDEP2097 TTGMDPQARR2107 MLWNVIVSII 2117 REGRAVVLTS2127 HSMEECEALC2137 TRLAIMVKGA2147 FRCMGTIQHL2157 KSKFGDGYIV 2167 TMKIKLLPDL2182 NPVEQFFQGN2192 FPGSVQRERH2202 YNMLQFQVSS2212 SSLARIFQLL 2222 LSHKDSLLIE2232 EYSVTQTTLD2242 QVFVNFAKQQ2252 T
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AJP or .AJP2 or .AJP3 or :3AJP;style chemicals stick;color identity;select .A:664 or .A:665 or .A:668 or .A:669 or .A:672 or .A:676 or .A:679 or .A:680 or .A:758 or .A:759 or .A:762 or .A:763 or .A:766 or .A:767 or .A:1016 or .A:1017 or .A:1060 or .A:1067 or .A:1789 or .A:1790 or .A:1793; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE664
3.678
TYR665
3.995
SER668
3.687
MET669
3.973
LYS672
2.847
LEU676
3.426
GLU679
2.719
LEU680
3.393
ALA758
3.574
SER759
3.921
ALA762
3.325
|
|||||
| Ligand Name: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human ABCA4 in the apo state | PDB:7E7I | ||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [3] |
| PDB Sequence |
MGFVRQIQLL
10 LWKNWTLRKR20 QKIRFVVELV30 WPLSLFLVLI40 WLRNANPLYS50 HHECHFPNKA 60 MPSAGMLPWL70 QGIFCNVNNP80 CFQSPTPGES90 PGIVSNYNNS100 ILARVYRDFQ 110 ELLMNAPESQ120 HLGRIWTELH130 ILSQFMDTLR140 THPERIAGRG150 IRIRDILKDE 160 ETLLLERFII215 FSQRRGAKTS231 LSQGTLQWLY245 ANVDFFKLFR255 VLPTLLDSRS 265 QGINLRSWGG275 ILSDMSPRIQ285 EFIHRPSMQD295 LLWVTRPLMQ305 NGGPETFTKL 315 MGILSDLLCG325 YPEGGGSRVL335 SFNWYEDNNY345 KAFLGIDSTR355 KDPIYSYDRR 365 TTSFCNALIQ375 SLESNPLTKI385 AWRAAKPLLM395 GKILYTPDSP405 AARRILKNAN 415 STFEELEHVR425 KLVKAWEEVG435 PQIWYFFDNS445 TQMNMIRDTL455 GVKDFLNRQL 468 GEEGITAEAI478 LNFLYKGPRE488 SQADNFDWRD501 IFNITDRTLR511 LVNQYLECLV 521 LDKFESYNDE531 TQLTQRALSL541 LEENMFWAGV551 VFPDMYPWTS561 SLPPHVKYKI 571 RMDIDVVEKT581 NKIKDRYWDS591 GPRADPVEDF601 RYIWGGFAYL611 QDMVEQGITR 621 SQVQAEAPVG631 IYLQQMPYPC641 FVDDSFMIIL651 NRCFPIFMVL661 AWIYSVSMTV 671 KSIVLEKELR681 LKETLKNQGV691 SNAVIWCTWF701 LDSFSIMSMS711 IFLLTIFIMH 721 GRILHYSDPF731 ILFLFLLAFS741 TATIMLCFLL751 STFFSKASLA761 AACSGVIYFT 771 LYLPHILCFA781 WQDRMTAELK791 KAVSLLSPVA801 FGFGTEYLVR811 FEEQGLGLQW 821 SNIGNSPTEG831 DEFSFLLSMQ841 MMLLDAAVYG851 LLAWYLDQVF861 DSFFEREHPG 924 WVPGVCVKNL934 VKIAVDRLNI951 TFYENQITAF961 LGHNGAGKTT971 TLSILTGLLP 981 PTSGTVLVGG991 RDIETSLDAV1001 RQSLGMCPQH1011 NILFHHLTVA1021 EHMLFYAQLK 1031 GKSQEEAQLE1041 MEAMLEDTGL1051 HHKRNEEAQD1061 LSGGMQRKLS1071 VAIAFVGDAK 1081 VVILDEPTSG1091 VDPYSRRSIW1101 DLLLKYRSGR1111 TIIMSTHHMD1121 EADLLGDRIA 1131 IIAQGRLYCS1141 GTPLFLKNCF1151 GTGLYLTLVR1161 KMKQVLDGDV1205 NELMDVVLHH 1215 VPEAKLVECI1225 GQELIFLLPN1235 KNFKHRAYAS1245 LFRELEETLA1255 DLGLSSFGIS 1265 DTPLEEIFLK1275 VTEDGPQLNT1346 GTQLVLQHVQ1356 ALLVKRFQHT1366 IRSHKDFLAQ 1376 IVLPATFVFL1386 ALMLSIVIPP1396 FGEYPALTLH1406 PWIYGQQYTF1416 FSMDEPGSEQ 1426 FTVLADVLLN1436 KPGFGNRCLK1446 EGWLPEYPCG1456 NSTPWKTPSV1466 SPNITQLFQK 1476 QKWTQVNPSP1486 SCRCSTREKL1496 TMLPECPEGA1506 GGLPPPQRTQ1516 RSTEILQDLT 1526 DRNISDFLVK1536 TYPALIRSSL1546 KSKFWVNEQR1556 YGGISIGGKL1566 PVVPITGEAL 1576 VGFLSDLGRI1586 MNVSGGPITR1596 EASKEIPDFL1606 KHLETEDNIK1616 VWFNNKGWHA 1626 LVSFLNVAHN1636 AILRASLPKD1646 RSPEEYGITV1656 ISQPLNLTKE1666 QLSEITVLTT 1676 SVDAVVAICV1686 IFSMSFVPAS1696 FVLYLIQERV1706 NKSKHLQFIS1716 GVSPTTYWVT 1726 NFLWDIMNYS1736 VSAGLVVGIF1746 IGFQKKAYTS1756 PENLPALVAL1766 LLLYGWAVIP 1776 MMYPASFLFD1786 VPSTAYVALS1796 CANLFIGINS1806 SAITFILELF1816 ENNRTLLRFN 1826 AVLRKLLIVF1836 PHFCLGRGLI1846 DLALSQAVTD1856 VYARFGEEHS1866 ANPFHWDLIG 1876 KNLFAMVVEG1886 VVYFLLTLLV1896 QRHFFIVDED1918 DDVAEERQRI1928 ITGGNKTDIL 1938 RLHELTKIYP1948 GTSSPAVDRL1958 CVGVRPGECF1968 GLLGVNGAGK1978 TTTFKMLTGD 1988 TTVTSGDATV1998 AGKSILTNIS2008 EVHQNMGYCP2018 QFDAIDELLT2028 GREHLYLYAR 2038 LRGVPAEEIE2048 KVANWSIKSL2058 GLTVYADCLA2068 GTYSGGNKRK2078 LSTAIALIGC 2088 PPLVLLDEPT2098 TGMDPQARRM2108 LWNVIVSIIR2118 EGRAVVLTSH2128 SMEECEALCT 2138 RLAIMVKGAF2148 RCMGTIQHLK2158 SKFGDGYIVT2168 MKIKLPDLNP2184 VEQFFQGNFP 2194 GSVQRERHYN2204 MLQFQVSSSS2214 LARIFQLLLS2224 EEYSVTQTTL2241 DQVFVNFAKQ 2251 Q
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3PE or .3PE2 or .3PE3 or :33PE;style chemicals stick;color identity;select .A:21 or .A:23 or .A:24 or .A:27 or .A:31 or .A:661 or .A:664 or .A:665 or .A:668 or .A:669 or .A:672 or .A:760 or .A:762 or .A:763 or .A:764 or .A:767 or .A:770 or .A:771 or .A:774 or .A:1017 or .A:1365 or .A:1369 or .A:1371 or .A:1372 or .A:1374 or .A:1375 or .A:1379 or .A:1383 or .A:1688 or .A:1692 or .A:1699 or .A:1700 or .A:1703 or .A:1788 or .A:1789 or .A:1790 or .A:1792 or .A:1793 or .A:1796 or .A:1797 or .A:1800; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLN21
3.659
ILE23
3.586
ARG24
4.130
VAL27
4.857
TRP31
3.998
LEU661
4.067
ILE664
3.822
TYR665
4.054
SER668
3.977
MET669
4.080
LYS672
4.419
LEU760
3.457
ALA762
3.458
ALA763
3.686
CYS764
3.603
VAL767
4.227
PHE770
3.652
THR771
3.926
LEU774
4.176
HIS1017
4.193
HIS1365
3.169
SER1369
4.267
LYS1371
3.023
ASP1372
3.441
LEU1374
3.612
ALA1375
3.767
LEU1379
3.527
PHE1383
3.952
PHE1688
4.218
PHE1692
4.898
LEU1699
3.797
TYR1700
4.591
GLN1703
3.120
PRO1788
4.132
SER1789
3.388
THR1790
4.299
TYR1792
3.902
VAL1793
1.493
SER1796
4.024
CYS1797
4.195
LEU1800
4.184
|
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular structures of the eukaryotic retinal importer ABCA4. Elife. 2021 Feb 19;10:e63524. | ||||
| REF 2 | Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease. Nat Commun. 2021 Oct 8;12(1):5902. | ||||
| REF 3 | Structural basis of substrate recognition and translocation by human ABCA4. Nat Commun. 2021 Jun 22;12(1):3853. | ||||
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