Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T49102 | Target Info | |||
Target Name | NIMA-related kinase 2 (NEK2) | ||||
Synonyms | Serine/threonine-protein kinase Nek2; NimA-related protein kinase 2; NimA-like protein kinase 1; Never in mitosis A-related kinase 2; NLK1; NEK2A; HSPK 21 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | NEK2 | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: adenosine diphosphate | Ligand Info | |||||
Structure Description | Human Nek2 kinase ADP-bound | PDB:2W5A | ||||
Method | X-ray diffraction | Resolution | 1.55 Å | Mutation | No | [1] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRRSL138 HRDLKPANVF148 LDGKQNVKLG158 DFGLARILTS 171 FAKTFVGTPY181 YMSPEQMNRM191 YNEKSDIWSL202 GCLLYELCAL212 MPPFTAFSQK 222 ELAGKIREGK232 FRRIPYRYSD242 ELNEIITRML252 NLKDYHRPSV262 EEILENPLIL 272 EHHHHHH
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Ligand Name: NU-6102 | Ligand Info | |||||
Structure Description | Nek2 bound to arylaminopurine 6 | PDB:5M57 | ||||
Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [2] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRRSD132 GGHTVLHRDL142 KPANVFLDGK152 QNVKLGDFVG 178 TPYYMSPEQM188 NRMSYNEKSD198 IWSLGCLLYE208 LCALMPPFTA218 FSQKELAGKI 228 REGKFRRIPY238 RYSDELNEII248 TRMLNLKDYH258 RPSVEEILEN268 PLILEHHHHH 278 H
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ILE14
4.285
GLY15
3.799
THR16
4.078
GLY17
3.522
SER18
4.906
TYR19
3.524
CYS22
3.550
VAL35
3.743
LYS37
3.268
VAL68
3.715
MET86
4.132
GLU87
2.841
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Ligand Name: 5-{6-[(1-Methylpiperidin-4-Yl)oxy]-1h-Benzimidazol-1-Yl}-3-{(1r)-1-[2-(Trifluoromethyl)phenyl]ethoxy}thiophene-2-Carboxamide | Ligand Info | |||||
Structure Description | Structure of NEK2 bound to CCT | PDB:2XNM | ||||
Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [3] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRRRD141 LKPANVFLDG151 KQNVKLGDFG161 LARILFVGTP 180 YYMSPEQMNR190 SYNEKSDIWS201 LGCLLYELCA211 LMPPFTAFSQ221 KELAGKIREG 231 KFRRIPYRYS241 DELNEIITRM251 LNLKDYHRPS261 VEEILENPLI271 LEHHHHHH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .WGZ or .WGZ2 or .WGZ3 or :3WGZ;style chemicals stick;color identity;select .A:14 or .A:15 or .A:16 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:92 or .A:93 or .A:96 or .A:145 or .A:146 or .A:148 or .A:158 or .A:159 or .A:160 or .A:162 or .A:163 or .A:166; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ILE14
3.305
GLY15
3.425
THR16
4.764
CYS22
3.068
VAL35
3.792
LYS37
2.762
VAL68
4.165
MET86
4.197
GLU87
3.220
TYR88
3.540
CYS89
2.672
GLU90
4.832
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Ligand Name: 3-[[6-(Cyclohexylmethoxy)-7~{h}-Purin-2-Yl]amino]-~{n},~{n}-Dimethyl-Benzamide | Ligand Info | |||||
Structure Description | Nek2 bound to arylaminopurine inhibitor 11 | PDB:5M53 | ||||
Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [2] |
PDB Sequence |
DYEVLYTIGT
16 GSYGRCQKIR26 RGKILVWKEL39 DYGSMTEAEK49 QMLVSEVNLL59 RELKHPNIVR 69 YYDRIIDRTN79 TTLYIVMEYC89 EGGDLASVIT99 KGTKERQYLD109 EEFVLRVMTQ 119 LTLALKECHR129 RSDGGHTVLH139 RDLKPANVFL149 DGKQNVKLGD159 FGLVGTPYYM 183 SPEQMNRMSY193 NEKSDIWSLG203 CLLYELCALM213 PPFTAFSQKE223 LAGKIREGKF 233 RRIPYRYSDE243 LNEIITRMLN253 LKDYHRPSVE263 EILENPLILE273 HHHHH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7GJ or .7GJ2 or .7GJ3 or :37GJ;style chemicals stick;color identity;select .A:14 or .A:15 or .A:16 or .A:17 or .A:19 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:148 or .A:159; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 3-[[6-(Cyclohexylmethoxy)-9~{h}-Purin-2-Yl]amino]benzamide | Ligand Info | |||||
Structure Description | Nek2 bound to arylaminopurine compound 8 | PDB:5M51 | ||||
Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [2] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRRSD132 GGHTVLHRDL142 KPANVFLDGK152 QNVKLGDFVG 178 TPYYMSPEQM188 NRMSYNEKSD198 IWSLGCLLYE208 LCALMPPFTA218 FSQKELAGKI 228 REGKFRRIPY238 RYSDELNEII248 TRMLNLKDYH258 RPSVEEILEN268 PLILEHHHHH 278
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NU6 or .NU62 or .NU63 or :3NU6;style chemicals stick;color identity;select .A:14 or .A:15 or .A:16 or .A:17 or .A:19 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:145 or .A:148 or .A:159; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 4-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]benzoic Acid | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to aminopyrazine compound 12 | PDB:2XKD | ||||
Method | X-ray diffraction | Resolution | 1.96 Å | Mutation | No | [4] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGRCQKI25 RRKSDGKILV35 WKELDYGSMT45 EAEKQMLVSE55 VNLLRELKHP 65 NIVRYYDRII75 DRTNTTLYIV85 MEYCEGGDLA95 SVITKGTKER105 QYLDEEFVLR 115 VMTQLTLALK125 ECHRRSDLKP144 ANVFLDGKQN154 VKLGDFTFVG178 TPYYMSPEQM 188 NRMSYNEKSD198 IWSLGCLLYE208 LCALMPPFTA218 FSQKELAGKI228 REGKFRRIPY 238 RYSDELNEII248 TRMLNLKDYH258 RPSVEEILEN268 PLILEHHHHH278 H |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .T3M or .T3M2 or .T3M3 or :3T3M;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:70 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:96 or .A:148 or .A:158 or .A:159 or .A:160; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 4-{5-[(1-Methylpiperidin-4-YL)oxy]-1H-benzimidazol-1-YL}-2-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}benzamide | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to CCT244858 | PDB:2XNP | ||||
Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [3] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGYGRCQ23 KIRRKSDGKI33 LVWKELDYGS43 MTEAEKQMLV53 SEVNLLRELK 63 HPNIVRYYDR73 IIDRTNTTLY83 IVMEYCEGGD93 LASVITKGTK103 ERQYLDEEFV 113 LRVMTQLTLA123 LKECHRRSHR140 DLKPANVFLD150 GKQNVKLGDF160 GLFVGTPYYM 183 SPEQMNRNEK196 SDIWSLGCLL206 YELCALMPPF216 TAFSQKELAG226 KIREGKFRRI 236 PYRYSDELNE246 IITRMLNLKD256 YHRPSVEEIL266 ENPLILEHHH276 HHH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .WCX or .WCX2 or .WCX3 or :3WCX;style chemicals stick;color identity;select .A:14 or .A:15 or .A:16 or .A:19 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:145 or .A:146 or .A:148 or .A:158 or .A:159 or .A:160; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ILE14
3.388
GLY15
3.504
THR16
4.904
TYR19
2.988
CYS22
3.013
VAL35
3.830
LYS37
3.823
VAL68
3.881
MET86
3.818
GLU87
3.259
TYR88
3.636
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Ligand Name: 5-{6-[(1-Methylpiperidin-4-Yl)oxy]-1h-Benzimidazol-1-Yl}-3-{[2-(Trifluoromethyl)benzyl]oxy}thiophene-2-Carboxamide | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to CCT243779 | PDB:2XNO | ||||
Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [3] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRRSR140 DLKPANVFLD150 GKQNVKLGDF160 FVGTPYYMSP 185 EQMNRNEKSD198 IWSLGCLLYE208 LCALMPPFTA218 FSQKELAGKI228 REGKFRRIPY 238 RYSDELNEII248 TRMLNLKDYH258 RPSVEEILEN268 PLILEHHHHH278 H |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ED8 or .ED82 or .ED83 or :3ED8;style chemicals stick;color identity;select .A:14 or .A:15 or .A:16 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:92 or .A:93 or .A:96 or .A:145 or .A:146 or .A:148 or .A:158 or .A:159 or .A:160; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: (3r,4r)-1-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]-3-Ethylpiperidine-4-Carboxylic Acid | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to aminopyrazine compound 23 | PDB:2XK7 | ||||
Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | No | [4] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGRCQKI25 RRKSDGKILV35 WKELDYGSMT45 EAEKQMLVSE55 VNLLRELKHP 65 NIVRYYDRII75 DRTNTTLYIV85 MEYCEGGDLA95 SVITKGTKER105 QYLDEEFVLR 115 VMTQLTLALK125 ECHRRSRDLK143 PANVFLDGKQ153 NVKLGDFVGT179 PYYMSPEQMN 189 NEKSDIWSLG203 CLLYELCALM213 PPFTAFSQKE223 LAGKIREGKF233 RRIPYRYSDE 243 LNEIITRMLN253 LKDYHRPSVE263 EILENPLILE273 HHHHHH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .30E or .30E2 or .30E3 or :330E;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:36 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:92 or .A:93 or .A:96 or .A:148 or .A:158 or .A:159; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 2-phenylazanyl-9~{H}-purine-6-carbonitrile | Ligand Info | |||||
Structure Description | Nek2 kinase bound to inhibitor 102 | PDB:6SGK | ||||
Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [5] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRRLK143 PANVFLDGKQ153 NVKLGDFVGT179 PYYMSPEQMN 189 RNEKSDIWSL202 GCLLYELCAL212 MPPFTAFSQK222 ELAGKIREGK232 FRRIPYRYSD 242 ELNEIITRML252 NLKDYHRPSV262 EEILENPLIL272 EHHHHHH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LCQ or .LCQ2 or .LCQ3 or :3LCQ;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:148; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide | Ligand Info | |||||
Structure Description | Nek2 bound to purine compound 51 | PDB:6SK9 | ||||
Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [6] |
PDB Sequence |
RAEDYEVLYT
13 IGTRCQKIRR27 KSDGKILVWK37 ELDYGSMTEA47 EKQMLVSEVN57 LLRELKHPNI 67 VRYYDRIIDR77 TNTTLYIVME87 YCEGGDLASV97 ITKGTKERQY107 LDEEFVLRVM 117 TQLTLALKEC127 HRRLKPANVF148 LDGKQNVKLG158 DFGTPYYMSP185 EQMNNEKSDI 199 WSLGCLLYEL209 CALMPPFTAF219 SQKELAGKIR229 EGKFRRIPYR239 YSDELNEIIT 249 RMLNLKDYHR259 PSVEEILENP269 LILEHHHHHH279
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .F9N or .F9N2 or .F9N3 or :3F9N;style chemicals stick;color identity;select .A:14 or .A:15 or .A:16 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:95 or .A:96 or .A:145 or .A:148; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 4-[(6-ethenyl-7H-purin-2-yl)amino]benzenesulfonamide | Ligand Info | |||||
Structure Description | Nek2 kinase covalently bound to 2-arylamino-6-ethynylpurine inhibitor 24 | PDB:6SGD | ||||
Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [5] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRLKP144 ANVFLDGKQN154 VKLGDVGTPY181 YMSPEQMNRM 191 SYNEKSDIWS201 LGCLLYELCA211 LMPPFTAFSQ221 KELAGKIREG231 KFRRIPYRYS 241 DELNEIITRM251 LNLKDYHRPS261 VEEILENPLI271 LEHHHHHH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LD5 or .LD52 or .LD53 or :3LD5;style chemicals stick;color identity;select .A:14 or .A:15 or .A:22 or .A:35 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:96 or .A:148; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 4-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]-2-Methoxybenzoic Acid | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to aminopyrazine compound 15 | PDB:2XK8 | ||||
Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [4] |
PDB Sequence |
SRAEDYEVLY
12 TIGTRCQKIR26 RKSDGKILVW36 KELDYGSMTE46 AEKQMLVSEV56 NLLRELKHPN 66 IVRYYDRIID76 RTNTTLYIVM86 EYCEGGDLAS96 VITKGTKERQ106 YLDEEFVLRV 116 MTQLTLALKE126 CHRRSRDLKP144 ANVFLDGKQN154 VKLGDFFVGT179 PYYMSPEQMN 189 NEKSDIWSLG203 CLLYELCALM213 PPFTAFSQKE223 LAGKIREGKF233 RRIPYRYSDE 243 LNEIITRMLN253 LKDYHRPSVE263 EILENPLILE273 HHHHHH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5R1 or .5R12 or .5R13 or :35R1;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:70 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:96 or .A:146 or .A:148 or .A:158 or .A:159 or .A:160; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 4-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]-2-Ethoxybenzoic Acid | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to aminopyrazine compound 17 | PDB:2XK4 | ||||
Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [4] |
PDB Sequence |
SRAEDYEVLY
12 TIGTYGRCQK24 IRRKSDGKIL34 VWKELDYGSM44 TEAEKQMLVS54 EVNLLRELKH 64 PNIVRYYDRI74 IDRTNTTLYI84 VMEYCEGGDL94 ASVITKGTKE104 RQYLDEEFVL 114 RVMTQLTLAL124 KECHRRSRDL142 KPANVFLDGK152 QNVKLGDFGL162 FVGTPYYMSP 185 EQMNRMNEKS197 DIWSLGCLLY207 ELCALMPPFT217 AFSQKELAGK227 IREGKFRRIP 237 YRYSDELNEI247 ITRMLNLKDY257 HRPSVEEILE267 NPLILEHHHH277 HH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OL2 or .OL22 or .OL23 or :3OL2;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:96 or .A:146 or .A:148 or .A:158 or .A:159 or .A:160; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 4-[2-Amino-5-(3,4,5-Trimethoxyphenyl)pyridin-3-Yl]benzoic Acid | Ligand Info | |||||
Structure Description | STRUCTURE OF NEK2 BOUND TO THE AMINOPYRIDINE CCT241950 | PDB:2WQO | ||||
Method | X-ray diffraction | Resolution | 2.17 Å | Mutation | No | [7] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGRCQKI25 RRKSDGKILV35 WKELDYGSMT45 EAEKQMLVSE55 VNLLRELKHP 65 NIVRYYDRII75 DRTNTTLYIV85 MEYCEGGDLA95 SVITKGTKER105 QYLDEEFVLR 115 VMTQLTLALK125 ECHRRLKPAN146 VFLDGKQNVK156 LGDGTPYYMS184 PEQMNRNEKS 197 DIWSLGCLLY207 ELCALMPPFT217 AFSQKELAGK227 IREGKFRRIP237 YRYSDELNEI 247 ITRMLNLKDY257 HRPSVEEILE267 NPLILEHHHH277 HH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .VGK or .VGK2 or .VGK3 or :3VGK;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:70 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:96 or .A:148 or .A:158 or .A:159; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 1-[3-Amino-6-(3-Methoxyphenyl)pyrazin-2-Yl]piperidine-4-Carboxylic Acid | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to Aminipyrazine Compound 5 | PDB:2XKE | ||||
Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [4] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGRCQKI25 RRKSDGKILV35 WKELDYGSMT45 EAEKQMLVSE55 VNLLRELKHP 65 NIVRYYDRII75 DRTNTTLYIV85 MEYCEGGDLA95 SVITKGTKER105 QYLDEEFVLR 115 VMTQLTLALK125 ECHRRSDLKP144 ANVFLDGKQN154 VKLGDFTPYY182 MSPEQMNNEK 196 SDIWSLGCLL206 YELCALMPPF216 TAFSQKELAG226 KIREGKFRRI236 PYRYSDELNE 246 IITRMLNLKD256 YHRPSVEEIL266 ENPLILEHHH276 HHH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .WI2 or .WI22 or .WI23 or :3WI2;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:70 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:92 or .A:93 or .A:148 or .A:158 or .A:159; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 4-[3-Amino-6-(3-Ethylthiophen-2-Yl)pyrazin-2-Yl]cyclohexane-1-Carboxylic Acid | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to Aminopyrazine compound 35 | PDB:2XK3 | ||||
Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [4] |
PDB Sequence |
SRAEDYEVLY
12 TIGTRCQKIR26 RKSDGKILVW36 KELDYGSMTE46 AEKQMLVSEV56 NLLRELKHPN 66 IVRYYDRIID76 RTNTTLYIVM86 EYCEGGDLAS96 VITKGTKERQ106 YLDEEFVLRV 116 MTQLTLALKE126 CHRRSRDLKP144 ANVFLDGKQN154 VKLGDFGVGT179 PYYMSPEQMN 189 RNEKSDIWSL202 GCLLYELCAL212 MPPFTAFSQK222 ELAGKIREGK232 FRRIPYRYSD 242 ELNEIITRML252 NLKDYHRPSV262 EEILENPLIL272 EHHHHHH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .XK3 or .XK32 or .XK33 or :3XK3;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:70 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:148 or .A:158 or .A:159 or .A:160; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide | Ligand Info | |||||
Structure Description | Human Kinase with pyrrole-indolinone ligand | PDB:2JAV | ||||
Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | Yes | [8] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDTLYIVM86 EYCEGGDLAS96 VITKGTKERQ106 YLDEEFVLRV 116 MTQLTLALKE126 CHRRSDLKPA145 NVFLDGKQNV155 KLGDFGLARI165 LGTPYYMSPE 186 QMNRMSYNEK196 SDIWSLGCLL206 YELCALMPPF216 TAFSQKELAG226 KIREGKFRRI 236 PYRYSDELNE246 IITRMLNLKD256 YHRPSVEEIL266 ENPLILEHHH276 HHH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5Z5 or .5Z52 or .5Z53 or :35Z5;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:92 or .A:93 or .A:96 or .A:148 or .A:162 or .A:166; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: Cis-4-[3-Amino-6-(3-Cyclopropylthiophen-2-Yl)pyrazin-2-Yl]cyclohexanecarboxylic Acid | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to aminopyrazine compound 36 | PDB:2XK6 | ||||
Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [4] |
PDB Sequence |
RAEDYEVLYT
13 IGRCQKIRRK28 SDGKILVWKE38 LDYGSMTEAE48 KQMLVSEVNL58 LRELKHPNIV 68 RYYDRIIDRT78 NTTLYIVMEY88 CEGGDLASVI98 TKGTKERQYL108 DEEFVLRVMT 118 QLTLALKECH128 RRSRDLKPAN146 VFLDGKQNVK156 LGDVGTPYYM183 SPEQMNRNEK 196 SDIWSLGCLL206 YELCALMPPF216 TAFSQKELAG226 KIREGKFRRI236 PYRYSDELNE 246 IITRMLNLKD256 YHRPSVEEIL266 ENPLILEHHH276 HHH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .EQH or .EQH2 or .EQH3 or :3EQH;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:70 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:146 or .A:148 or .A:158 or .A:159; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 4-[(6-ethyl-7~{H}-purin-2-yl)amino]benzenesulfonamide | Ligand Info | |||||
Structure Description | Nek2 kinase bound to inhibitor 96 | PDB:6SGI | ||||
Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [5] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRRSH139 RDLKPANVFL149 DGKQNVKLGD159 FVGTPYYMSP 185 EQMNRYNEKS197 DIWSLGCLLY207 ELCALMPPFT217 AFSQKELAGK227 IREGKFRRIP 237 YRYSDELNEI247 ITRMLNLKDY257 HRPSVEEILE267 NPLILEHHHH277 HH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LCB or .LCB2 or .LCB3 or :3LCB;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:96 or .A:148; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 1-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]piperidine-4-Carboxylic Acid | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to aminopyrazine compound 2 | PDB:2XKF | ||||
Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | No | [4] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGRCQKI25 RRKSDGKILV35 WKELDYGSMT45 EAEKQMLVSE55 VNLLRELKHP 65 NIVRYYDRII75 DRTNTTLYIV85 MEYCEGGDLA95 SVITKGTKER105 QYLDEEFVLR 115 VMTQLTLALK125 ECHRRSRDLK143 PANVFLDGKQ153 NVKLGDFFVG178 TPYYMSPEQM 188 NRSYNEKSDI199 WSLGCLLYEL209 CALMPPFTAF219 SQKELAGKIR229 EGKFRRIPYR 239 YSDELNEIIT249 RMLNLKDYHR259 PSVEEILENP269 LILEHHHHHH279 |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BX1 or .BX12 or .BX13 or :3BX1;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:70 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:96 or .A:148 or .A:158 or .A:159 or .A:160; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 4-(2-Amino-5-{4-[(Dimethylamino)methyl]thiophen-2-Yl}pyridin-3-Yl)-2-{(1r)-1-[2-(Trifluoromethyl)phenyl]ethoxy}benzamide | Ligand Info | |||||
Structure Description | NEK2-EDE bound to CCT248662 | PDB:4A4X | ||||
Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [9] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRRSH139 RDLKPANVFL149 DGKQNVKLGD159 FGLVGTPYYM 183 SPEQMNRNEK196 SDIWSLGCLL206 YELCALMPPF216 TAFSQKELAG226 KIREGKFRRI 236 PYRYSDELNE246 IITRMLNLKD256 YHRPSVEEIL266 ENPLILEHHH276 HHH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .JUP or .JUP2 or .JUP3 or :3JUP;style chemicals stick;color identity;select .A:12 or .A:14 or .A:15 or .A:16 or .A:19 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:92 or .A:93 or .A:145 or .A:146 or .A:148 or .A:158 or .A:159 or .A:160; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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TYR12
4.699
ILE14
3.323
GLY15
3.596
THR16
4.886
TYR19
2.996
CYS22
3.324
VAL35
3.431
LYS37
3.849
VAL68
4.178
MET86
3.614
GLU87
2.805
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Ligand Name: 6-[(Z)-2-(diethylamino)ethenyl]-N-phenyl-7H-purin-2-amine | Ligand Info | |||||
Structure Description | Nek2 bound to arylaminopurine 71 | PDB:5M55 | ||||
Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [2] |
PDB Sequence |
SRAEDYEVLY
12 TIGTRCQKIR26 RKSDGKILVW36 KELDYGSMTE46 AEKQMLVSEV56 NLLRELKHPN 66 IVRYYDRIID76 RTNTTLYIVM86 EYCEGGDLAS96 VITKGTKERQ106 YLDEEFVLRV 116 MTQLTLALKE126 CHRRSLKPAN146 VFLDGKQNVK156 LGDTPYYMSP185 EQMNNEKSDI 199 WSLGCLLYEL209 CALMPPFTAF219 SQKELAGKIR229 EGKFRRIPYR239 YSDELNEIIT 249 RMLNLKDYHR259 PSVEEILENP269 LILEHHHHHH279
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7GG or .7GG2 or .7GG3 or :37GG;style chemicals stick;color identity;select .A:14 or .A:15 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:148; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: Phosphothiophosphoric acid-adenylate ester | Ligand Info | |||||
Structure Description | Human Nek2 kinase ATPgammaS-bound | PDB:2W5B | ||||
Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRRSL138 HRDLKPANVF148 LDGKQNVKLG158 DFGLARILNH 168 DTSFAKAFVG178 TPYYMSPEQM188 NRMSYNEKSD198 IWSLGCLLYE208 LCALMPPFTA 218 FSQKELAGKI228 REGKFRRIPY238 RYSDELNEII248 TRMLNLKDYH258 RPSVEEILEN 268 PLILEHHHHH278 H
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AGS or .AGS2 or .AGS3 or :3AGS;style chemicals stick;color identity;select .A:14 or .A:15 or .A:16 or .A:17 or .A:18 or .A:19 or .A:20 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:92 or .A:93 or .A:143 or .A:145 or .A:146 or .A:148 or .A:160 or .A:163; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ILE14
3.428
GLY15
3.771
THR16
3.985
GLY17
2.943
SER18
3.505
TYR19
3.330
GLY20
4.261
CYS22
3.768
VAL35
3.721
LYS37
2.783
VAL68
3.800
MET86
4.475
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Ligand Name: 4-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]-2-Methylbenzoic Acid | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to aminopyrazine compound 14 | PDB:2XKC | ||||
Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [4] |
PDB Sequence |
SRAEDYEVLY
12 TIGTYGRCQK24 IRRKSDGKIL34 VWKELDYGSM44 TEAEKQMLVS54 EVNLLRELKH 64 PNIVRYYDRI74 IDRTNTTLYI84 VMEYCEGGDL94 ASVITKGTKE104 RQYLDEEFVL 114 RVMTQLTLAL124 KECHRRSLKP144 ANVFLDGKQN154 VKLGDGTPYY182 MSPEQMNRNE 195 KSDIWSLGCL205 LYELCALMPP215 FTAFSQKELA225 GKIREGKFRR235 IPYRYSDELN 245 EIITRMLNLK255 DYHRPSVEEI265 LENPLILEHH275 HHHH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .4VQ or .4VQ2 or .4VQ3 or :34VQ;style chemicals stick;color identity;select .A:14 or .A:22 or .A:35 or .A:37 or .A:68 or .A:70 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:96 or .A:148 or .A:158 or .A:159; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 5-(1h-Benzimidazol-1-Yl)-3-{(1r)-1-[2-(Trifluoromethyl)phenyl]ethoxy}thiophene-2-Carboxamide | Ligand Info | |||||
Structure Description | Structure of Nek2 bound to CCT242430 | PDB:2XNN | ||||
Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [3] |
PDB Sequence |
SRAEDYEVLY
12 TIGTYGRCQK24 IRRKSDGKIL34 VWKELDYGSM44 TEAEKQMLVS54 EVNLLRELKH 64 PNIVRYYDRI74 IDRTNTTLYI84 VMEYCEGGDL94 ASVITKGTKE104 RQYLDEEFVL 114 RVMTQLTLAL124 KECHRRSRDL142 KPANVFLDGK152 QNVKLGDFGF176 VGTPYYMSPE 186 QMNRYNEKSD198 IWSLGCLLYE208 LCALMPPFTA218 FSQKELAGKI228 REGKFRRIPY 238 RYSDELNEII248 TRMLNLKDYH258 RPSVEEILEN268 PLILEHHHHH278 H |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .430 or .4302 or .4303 or :3430;style chemicals stick;color identity;select .A:14 or .A:15 or .A:16 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:92 or .A:93 or .A:145 or .A:146 or .A:148 or .A:158 or .A:159 or .A:160; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 4-(2-Amino-5-{4-[(dimethylamino)methyl]thiophen-2-YL}pyridin-3-YL)-2-{[(1R,2Z)-4,4,4-trifluoro-1-methylbut-2-EN-1-YL]oxy}benzamide | Ligand Info | |||||
Structure Description | Nek2 bound to hybrid compound 21 | PDB:4AFE | ||||
Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [9] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGSYGRC22 QKIRRKSDGK32 ILVWKELDYG42 SMTEAEKQML52 VSEVNLLREL 62 KHPNIVRYYD72 RIIDRTNTTL82 YIVMEYCEGG92 DLASVITKGT102 KERQYLDEEF 112 VLRVMTQLTL122 ALKECHRRSH139 RDLKPANVFL149 DGKQNVKLGD159 FGLVGTPYYM 183 SPEQMNRNEK196 SDIWSLGCLL206 YELCALMPPF216 TAFSQKELAG226 KIREGKFRRI 236 PYRYSDELNE246 IITRMLNLKD256 YHRPSVEEIL266 ENPLILEHHH276 HHH |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GGY or .GGY2 or .GGY3 or :3GGY;style chemicals stick;color identity;select .A:12 or .A:14 or .A:15 or .A:16 or .A:19 or .A:22 or .A:35 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:92 or .A:93 or .A:146 or .A:148 or .A:158 or .A:159 or .A:160; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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Ligand Name: 2-[4-[(6-ethenyl-7H-purin-2-yl)amino]phenyl]acetamide | Ligand Info | |||||
Structure Description | Nek2 kinase covalently bound to 2-arylamino-6-ethynylpurine inhibitor 66 | PDB:6SGH | ||||
Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | No | [5] |
PDB Sequence |
SRAEDYEVLY
12 TIGTGRCQKI25 RRKSDGKILV35 WKELDYGSMT45 EAEKQMLVSE55 VNLLRELKHP 65 NIVRYYDRII75 DRTNTTLYIV85 MEYCEGGDLA95 SVITKGTKER105 QYLDEEFVLR 115 VMTQLTLALK125 ECHRLKPANV147 FLDGKQNVKL157 GDYYMSPEQM188 NYNEKSDIWS 201 LGCLLYELCA211 LMPPFTAFSQ221 KELAGKIREG231 KFRRIPYRYS241 DELNEIITRM 251 LNLKDYHRPS261 VEEILENPLI271 LEHHHHHH
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LCW or .LCW2 or .LCW3 or :3LCW;style chemicals stick;color identity;select .A:14 or .A:15 or .A:22 or .A:23 or .A:35 or .A:36 or .A:37 or .A:68 or .A:86 or .A:87 or .A:88 or .A:89 or .A:90 or .A:91 or .A:92 or .A:93 or .A:96 or .A:148; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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References | Top | ||||
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REF 1 | Insights into the conformational variability and regulation of human Nek2 kinase. J Mol Biol. 2009 Feb 20;386(2):476-85. | ||||
REF 2 | Structure-guided design of purine-based probes for selective Nek2 inhibition. Oncotarget. 2017 Mar 21;8(12):19089-19124. | ||||
REF 3 | Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship. J Med Chem. 2011 Mar 24;54(6):1626-39. | ||||
REF 4 | Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem. 2010 Nov 11;53(21):7682-98. | ||||
REF 5 | 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase. RSC Med Chem. 2020 May 22;11(6):707-731. | ||||
REF 6 | Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine. Biochem J. 2020 Apr 30;477(8):1525-1539. | ||||
REF 7 | An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. Mol Cell. 2009 Nov 25;36(4):560-70. | ||||
REF 8 | Structure and regulation of the human Nek2 centrosomal kinase. J Biol Chem. 2007 Mar 2;282(9):6833-42. | ||||
REF 9 | Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem. 2012 Apr 12;55(7):3228-41. |
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