Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48268 | Target Info | |||
| Target Name | Melatonin receptor type 1B (MTNR1B) | ||||
| Synonyms | Mel1b receptor; Mel1b melatonin receptor; Mel-1B-R | ||||
| Target Type | Successful Target | ||||
| Gene Name | MTNR1B | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Ramelteon | Ligand Info | |||||
| Structure Description | XFEL crystal structure of human melatonin receptor MT2 in complex with ramelteon | PDB:6ME9 | ||||
| Method | X-ray diffraction | Resolution | 3.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
ADLEDNWETL
2010 NDNLKVIEKA2020 DNAAQVKDAL2030 TKMRAAALDA2040 QKATPPKLED2050 KSPDSPEMKD 2060 FRHGFDILVG2070 QIDDALKLAN2080 EGKVKEAQAA2090 AEQLKTTRNA2100 YIQKYLGDGA 34 RPSWVAPALS44 AVLIVTTAVD54 VVGNLLVILS64 VLRNRKLRNA74 GNLFLVSLAL 84 ANLVVAFYPY94 PLILVAIFYD104 GWAFGEEHCK114 ASAFVMGLSV124 IGSVWNITAI 134 AIDRYLYICH144 SMAYHRIYRR154 WHTPLHICLI164 WLLTVVALLP174 NFFVGSLEYD 184 PRIYSCTFIQ194 TASTQYTAAV204 VVIHFLLPIA214 VVSFCYLRIW224 VLVLQARMKK 1002 YTCTVCGYIY1012 NPEDGDPDNG1022 VNPGTDFKDI1032 PDDWVCPLCG1042 VGKDQFEEVE 1052 CLKPSDLRSF250 LTMFVVFVIF260 AICFAPLNCI270 GLAVAINPQE280 MAPQIPEGLF 290 VTSYLLAYFN300 SCLNPIVYGL310 LDQNFRREYK320 RILLALWN
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide | Ligand Info | |||||
| Structure Description | XFEL crystal structure of human melatonin receptor MT2 in complex with 2-phenylmelatonin | PDB:6ME6 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
ADLEDNWETL
2010 NDNLKVIEKA2020 DNAAQVKDAL2030 TKMRAAALDA2040 QKATPPKLED2050 KSPDSPEMKD 2060 FRHGFDILVG2070 QIDDALKLAN2080 EGKVKEAQAA2090 AEQLKTTRNA2100 YIQKYLGDGA 34 RPSWVAPALS44 AVLIVTTAVD54 VVGNLLVILS64 VLRNRKLRNA74 GNLFLVSLAL 84 ANLVVAFYPY94 PLILVAIFYD104 GWAFGEEHCK114 ASAFVMGLSV124 IGSVWNITAI 134 AIDRYLYICH144 SMAYHRIYRR154 WHTPLHICLI164 WLLTVVALLP174 NFFVGSLEYD 184 PRIYSCTFIQ194 TASTQYTAAV204 VVIHFLLPIA214 VVSFCYLRIW224 VLVLQARMKK 1002 YTCTVCGYIY1012 NPEDGDPDNG1022 VNPGTDFKDI1032 PDDWVCPLCG1042 VGKDQFEEVE 1052 CLKPSDLRSF250 LTMFVVFVIF260 AICFAPLNCI270 GLAVAINPQE280 MAPQIPEGLF 290 VTSYLLAYFN300 SCLNPIVYGL310 LDQNFRREYK320 RILLALWN
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ALA117
2.890
PHE118
4.945
MET120
3.667
GLY121
3.409
VAL124
3.638
ILE125
3.989
LEU172
4.490
ASN175
2.841
LEU181
3.875
THR191
3.794
PHE192
3.518
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | XFEL structures of the human MT(2) melatonin receptor reveal the basis of subtype selectivity. Nature. 2019 May;569(7755):289-292. | ||||
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