Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T47888 Target Info
Target Name Sphingosine-1-phosphate receptor 2 (S1PR2)
Synonyms Sphingosine 1-phosphate receptor Edg-5; S1PR2; S1P2; S1P receptor Edg-5; S1P receptor 2; Endothelial differentiation G-protein coupled receptor 5
Target Type Clinical trial Target
Gene Name S1PR2
Biochemical Class GPCR rhodopsin
UniProt ID
S1PR2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Sphingosine-1-phosphate Ligand Info
Structure Description Structure of S1PR2-heterotrimeric G13 signaling complex PDB:7T6B
Method Electron microscopy Resolution 3.19 Å Mutation No [1]
PDB Sequence
NKVQEHYNYT
21
KTSRQVASAF
39
IVILCCAIVV
49
ENLLVLIAVA
59
RNSKFHSAMY
69

LFLGNLAASD
79
LLAGVAFVAN
89
TLLSGSVTLR
99
LTPVQWFARE
109
GSAFITLSAS
119

VFSLLAIAIE
129
RHVAIAKVKL
139
YGSDKSCRML
149
LLIGASWLIS
159
LVLGGLPILG
169

WNCLGHLEAC
179
STVLPLYAKH
189
YVLCVVTIFS
199
IILLAIVALY
209
VRIYCVVRSS
219

QTLALLKTVT
236
IVLGVFIVCW
246
LPAFSILLLD
256
YACPVHSCPI
266
LYKAHYFFAV
276

STLNSLLNPV
286
IYTW
Residue
Distance (Å)
TYR18
4.936
ARG33
3.691
ASN89
2.899
SER93
3.299
LEU98
3.571
ARG108
4.031
GLU109
3.375
ALA112
3.976
PHE113
3.532
LEU116
4.227
SER117
3.134
VAL120
4.497
Residue
Distance (Å)
PHE121
2.967
LEU162
4.133
VAL182
4.331
LEU183
3.845
VAL194
3.772
ILE197
4.380
PHE198
4.342
TRP246
3.833
LEU253
4.748
HIS271
3.882
PHE274
3.349
References  Top
REF 1 Structure of S1PR2-heterotrimeric G(13) signaling complex. Sci Adv. 2022 Apr;8(13):eabn0067.

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