Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47583 | Target Info | |||
| Target Name | Werner syndrome ATP-dependent helicase (WRN) | ||||
| Synonyms | DNA helicase, RecQ-like type 3; RecQ3; Exonuclease WRN; RecQ protein-like 2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | WRN | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: adenosine diphosphate | Ligand Info | |||||
| Structure Description | Crystal structure of Werner syndrome helicase | PDB:6YHR | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | Yes | [1] |
| PDB Sequence |
LWPAPNEEQV
537 TCLKMYFGHS547 SFKPVQWKVI557 HSVLEERRDN567 VAVMATGYGK577 SLCFQYPPVY 587 VGKIGLVISP597 LISLMEDQVL607 QLKMSNIPAC617 FLGSAQSENV627 LTDIKLGKYR 637 IVYVTPEYCS647 GNMGLLQQLE657 ADIGITLIAV667 DEAHCISEWG677 HDFRDSFRKL 687 GSLKTALPMV697 PIVALTATAS707 SSIREDIVRC717 LNLRNPQITC727 TGFDRPNLYL 737 EVRRKTGNIL747 QDLQPFLVKT757 SSHWEFEGPT767 IIYCPSRKMT777 QQVTGELRKL 787 NLSCGTYHAG797 MSFSTRKDIH807 HRFVRDEIQC817 VIATIAFGMG827 INKADIRQVI 837 HYGAPKDMES847 YYQEIGRAGR857 DGLQSSCHVL867 WAPADINLNR877 HLLTEIRNEK 887 FRLYKLKMMA897 KMEKYLHSSR907 CRRQIILSHF917 EDKQVQKASL927 GIMGTEKCCD 937 NCRSRLDHCY947 SMDTSWDFGP961 QAFKLLSAVD971 ILGEKFGIGL981 PILFLRGSNS 991 QRLADQYRRH1001 SLFGTGKDQT1011 ESWWKAFSRQ1021 LITEGFLVEV1031 SRYNKFMKIC 1041 ALTKKGRNWL1051 HKANTESQSL1061 ILQANEELCP1071 K
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| Ligand Name: 2'-Deoxyguanosine-5'-Monophosphate | Ligand Info | |||||
| Structure Description | WRN exonuclease, Mn dGMP complex | PDB:2FC0 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [2] |
| PDB Sequence |
HHSVFEDDLP
45 FLEFTGSIVY55 SYDASDCSFL65 SEDISMSLSD75 GDVVGFDMEW85 PPLYNRGKLG 95 KVALIQLCVS105 ESKCYLFHVS115 SMSVFPQGLK125 MLLENKAVKK135 AGVGIEGDQW 145 KLLRDFDIKL155 KNFVELTDVA165 NKKLKCTETW175 SLNSLVKHLL185 GKQLLKDKSI 195 RCSNWSKFPL205 TEDQKLYAAT215 DAYAGFIIYR225 NLEILD
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers. Life Sci Alliance. 2020 Nov 16;4(1):e202000795. | ||||
| REF 2 | WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol. 2006 May;13(5):414-22. | ||||
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