Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T46929 Target Info
Target Name Eukaryotic translation initiation factor 5A-1 (EIF5A)
Synonyms eIF-5A1; eIF-5A-1; eIF-5A; eIF-4D; Rev-binding factor; Eukaryotic initiation factor 5A isoform 1
Target Type Literature-reported Target
Gene Name EIF5A
UniProt ID
IF5A1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: N(6)-(4-Amino-2-hydroxybutyl)-L-lysine Ligand Info
Structure Description Crystal structure of RanGTP-Exportin 4-eIF5A complex PDB:5DLQ
Method X-ray diffraction Resolution 3.20 Å Mutation Yes [1]
PDB Sequence
SATFPMQCSA
24
LRKNGFVVLK
34
GRPCKIVEMS
44
TSKTGHGHAK
55
VHLVGIDIFT
65

GKKYEDICPS
75
THNMDVPNIK
85
RNDFQLIGIQ
95
DGYLSLLQDS
105
GEVREDLRLP
115

EGDLGKEIEQ
125
KYDCGEEILI
135
TVLSAMTEEA
145
AVAIKAM
Residue
Distance (Å)
LYS47
2.778
THR48
4.535
GLY49
1.329
Residue
Distance (Å)
HIS51
1.330
GLY52
3.333
References  Top
REF 1 Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nat Commun. 2016 Jun 16;7:11952.

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