Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46365 | Target Info | |||
| Target Name | M-phase inducer phosphatase 2 (MPIP2) | ||||
| Synonyms | Dual specificity phosphatase Cdc25B; Cdc25B phosphatase; CDC25HU2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CDC25B | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Tungstate | Ligand Info | |||||
| Structure Description | HUMAN CDC25B CATALYTIC DOMAIN WITH TUNGSTATE | PDB:1CWS | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
SDHRELIGDY
382 SKAFLLQTVD392 GKHQDLKYIS402 PETMVALLTG412 KFSNIVDKFV422 IVDCRYPYEY 432 EGGHIKTAVN442 LPLERDAESF452 LLKSPIAPCS462 LDKRVILIFH472 CEFSSERGPR 482 MCRFIRERDR492 AVNDYPSLYY502 PEMYILKGGY512 KEFFPQHPNF522 CEPQDYRPMN 532 HEAFKDELKT542 FRLKTRSWA
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| Ligand Name: 2-[(2-Cyano-3-Fluoro-5-Hydroxyphenyl)sulfanyl]ethanesulfonic Acid | Ligand Info | |||||
| Structure Description | Structure of the CDC25B Phosphatase Catalytic Domain with Bound Inhibitor | PDB:4WH9 | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | Yes | [2] |
| PDB Sequence |
HRELIGDYSK
384 AFLLQTVDGK394 HQDLKYISPE404 TMVALLTGKF414 SNIVDKFVIV424 DCRYPYEYEG 434 GHIKTAVNLP444 LERDAESFLL454 KSPIAPCSLD464 KRVILIFHSE474 FSSERGPRMC 484 RFIRERDRAV494 NDYPSLYYPE504 MYILKGGYKE514 FFPQHPNFCE524 PQDYRPMNHE 534 AFKDELKTFR544 LKTRSWA
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| Ligand Name: 2-Fluoro-4-hydroxybenzonitrile | Ligand Info | |||||
| Structure Description | Structure of the CDC25B Phosphatase Catalytic Domain with Bound Ligand | PDB:4WH7 | ||||
| Method | X-ray diffraction | Resolution | 1.62 Å | Mutation | Yes | [2] |
| PDB Sequence |
DHRELIGDYS
383 KAFLLQTVDG393 KHQDLKYISP403 ETMVALLTGK413 FSNIVDKFVI423 VDCRYPYEYE 433 GGHIKTAVNL443 PLERDAESFL453 LKSPIAPCSL463 DKRVILIFHS473 EFSSERGPRM 483 CRFIRERDRA493 VNDYPSLYYP503 EMYILKGGYK513 EFFPQHPNFC523 EPQDYRPMNH 533 EAFKDELKTF543 RLKTRSWA
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle. J Mol Biol. 1999 Oct 29;293(3):559-68. | ||||
| REF 2 | Inhibition of CDC25B phosphatase through disruption of protein-protein interaction. ACS Chem Biol. 2015 Feb 20;10(2):390-4. | ||||
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