Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T45287 | Target Info | |||
| Target Name | Aspartyl aminopeptidase (DNPEP) | ||||
| Synonyms | DAP; ASPEP | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | DNPEP | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Hydroxylated lecithin | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Aspartyl Aminopeptidase (DNPEP) in complex with Aspartic acid Hydroxamate | PDB:4DYO | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
GKARKEAVQT
16 AAKELLKFVN26 RSPSPFHAVA36 ECRNRLLQAG46 FSELKETEKW56 NIKPESKYFM 66 TRNSSTIIAF76 AVGGQYVPGN86 GFSLIGAHTD96 SPCLRVKRRS106 RRSQVGFQQV 116 GVETYGGGIW126 STWFDRDLTL136 AGRVIVKCPT146 SGRLEQQLVH156 VERPILRIPH 166 LAIHLQRNIN176 ENFGPNTEMH186 LVPILATAIQ196 EELEKGTERH216 HSVLMSLLCA 226 HLGLSPKDIV236 EMELCLADTQ246 PAVLGGAYDE256 FIFAPRLDNL266 HSCFCALQAL 276 IDSCAGPGSL286 ATEPHVRMVT296 LYDNEEVGSE306 SAQGAQSLLT316 ELVLRRISAS 326 CQHPTAFEEA336 IPKSFMISAD346 MAHAVHPNYL356 DKHEENHRPL366 FHKGPVIKVN 376 SKQRYASNAV386 SEALIREVAN396 KVKVPLQDLM406 VRNDTPCGTT416 IGPILASRLG 426 LRVLDLGSPQ436 LAMHSIREMA446 CTTGVLQTLT456 LFKGFFELFP466 SLAENLY |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family. BMC Struct Biol. 2012 Jun 21;12:14. | ||||
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