Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T45074 | Target Info | |||
| Target Name | Carnitine acyltransferase (CRAT) | ||||
| Synonyms | Carnitine acetylase; Carnitine O-acetyltransferase; CRAT | ||||
| Target Type | Discontinued Target | ||||
| Gene Name | CRAT | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: CS-4771 | Ligand Info | |||||
| Structure Description | Structural and Mutational Characterization of L-carnitine Binding to Human carnitine Acetyltransferase | PDB:1S5O | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [1] |
| PDB Sequence |
HHTDPLPRLP
18 VPPLQQSLDH28 YLKALQPIVS38 EEEWAHTKQL48 VDEFQASGGV58 GERLQKGLER 68 RARKTENWLS78 EWWLKTAYLQ88 YRQPVVIYSS98 PGVMLPKQDF108 VDLQGQLRFA 118 AKLIEGVLDF128 KVMIDNETLP138 VEYLGGKPLC148 MNQYYQILSS158 CRVPGPKQDT 168 VSNFSKTKKP178 PTHITVVHNY188 QFFELDVYHS198 DGTPLTADQI208 FVQLEKIWNS 218 SLQTNKEPVG228 ILTSNHRNSW238 AKAYNTLIKD248 KVNRDSVRSI258 QKSIFTVCLD 268 ATMPRVSEDV278 YRSHVAGQML288 HGGGSRLNSG298 NRWFDKTLQF308 IVAEDGSCGL 318 VYEHAAAEGP328 PIVTLLDYVI338 EYTKKPELVR348 SPMVPLPMPK358 KLRFNITPEI 368 KSDIEKAKQN378 LSIMIQDLDI388 TVMVFHHFGK398 DFPKSEKLSP408 DAFIQMALQL 418 AYYRIYGQAC428 ATYESASLRM438 FHLGRTDTIR448 SASMDSLTFV458 KAMDDSSVTE 468 HQKVELLRKA478 VQAHRGYTDR488 AIRGEAFDRH498 LLGLKLQAIE508 DLVSTPDIFM 518 DTSYAIAMHF528 HLSTSQVPAK538 TDCVMFFGPV548 VPDGYGVCYN558 PMEAHINFSL 568 SAYNSCAETN578 AARLAHYLEK588 ALLDMRALLQ598 S
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. J Struct Biol. 2004 Jun;146(3):416-24. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.