Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T44479 | Target Info | |||
Target Name | Gap junction alpha-1 protein (GJA1) | ||||
Synonyms | Gap junction 43 kDa heart protein; GJAL; Cx43; Connexin-43; Connexin 43 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | GJA1 | ||||
Biochemical Class | Gap junction-forming connexin | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Tetradecane | Ligand Info | |||||
Structure Description | Structure of connexin43/Cx43/GJA1 gap junction intercellular channel in LMNG/CHS detergents at pH ~8.0 | PDB:7F92 | ||||
Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
PDB Sequence |
GDWSALGKLL
11 DKVQAYSTAG21 GKVWLSVLFI31 FRILLLGTAV41 ESAWGDEQSA51 FRCNTQQPGC 61 ENVCYDKSFP71 ISHVRFWVLQ81 IIFVSVPTLL91 YLAHVFYVMR101 KEEKLNKKRG 149 GLLRTYIISI159 LFKSIFEVAF169 LLIQWYIYGF179 SLSAVYTCKR189 DPCPHQVDCF 199 LSRPTEKTIF209 IIFMLVVSLV219 SLALNIIELF229 YVFFKG
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TRP4
4.075
ALA6
3.800
LEU7
3.730
GLY8
4.005
LEU10
3.798
LEU11
4.338
PHE30
4.722
ILE34
3.893
LEU35
4.656
LEU37
4.438
GLY38
4.431
THR39
3.910
GLU42
3.530
PRO71
3.757
ILE72
4.424
PHE77
3.923
VAL79
4.095
LEU80
4.619
ILE82
3.713
ILE83
3.929
PHE84
4.539
SER86
3.736
VAL87
3.908
PRO88
3.981
LEU90
3.776
LEU91
3.960
TYR92
4.337
HIS95
3.610
PHE97
3.621
TYR98
4.227
THR154
4.118
ILE157
4.401
SER158
3.927
PHE161
4.206
PHE165
3.944
ALA168
4.981
PHE169
3.940
ILE172
4.253
TYR175
4.381
ILE176
4.322
PHE179
4.106
SER180
4.967
THR204
4.040
THR207
4.799
ILE208
4.342
ILE211
4.063
PHE212
3.699
LEU214
4.657
VAL215
4.268
LEU218
3.934
VAL219
3.801
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Click to View More Binding Site Information of This Target and Ligand Pair |
References | Top | ||||
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REF 1 | Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM. Nat Commun. 2023 Feb 18;14(1):931. |
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