Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T44057 | Target Info | |||
Target Name | Aquaporin-1 (AQP1) | ||||
Synonyms | Water channel protein for red blood cells and kidney proximal tubule; Urine water channel; CHIP28; Aquaporin-CHIP; AQP-1 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | AQP1 | ||||
Biochemical Class | Major intrinsic protein | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Cholesterol | Ligand Info | |||||
Structure Description | Erythrocyte ankyrin-1 complex class 2 local refinement of AQP1 (C4 symmetry applied) | PDB:7UZE | ||||
Method | Electron microscopy | Resolution | 2.40 Å | Mutation | No | [1] |
PDB Sequence |
SEFKKKLFWR
12 AVVAEFLATT22 LFVFISIGSA32 LGFKYPVGNN42 QTAVQDNVKV52 SLAFGLSIAT 62 LAQSVGHISG72 AHLNPAVTLG82 LLLSQISIFR93 ALMYIIAQCV103 GAIVATAILS 113 GITSSLTGNS123 LGRNDLADGV133 NSGQGLGIEI143 IGTLQLVLCV153 LATTDRRRRD 163 LGGSAPLAIG173 LSVALGHLLA183 IDYTGCGINP193 ARSFGSAVIT203 HNFSNHWIFW 213 VGPFIGGALA223 VLIYDFILAP233 RSSDLTDRVK243 VWTSGQ
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Ligand Name: S-Palmitoyl-L-cysteine | Ligand Info | |||||
Structure Description | Erythrocyte ankyrin-1 complex class 2 local refinement of AQP1 (C4 symmetry applied) | PDB:7UZE | ||||
Method | Electron microscopy | Resolution | 2.40 Å | Mutation | No | [1] |
PDB Sequence |
SEFKKKLFWR
12 AVVAEFLATT22 LFVFISIGSA32 LGFKYPVGNN42 QTAVQDNVKV52 SLAFGLSIAT 62 LAQSVGHISG72 AHLNPAVTLG82 LLLSQISIFR93 ALMYIIAQCV103 GAIVATAILS 113 GITSSLTGNS123 LGRNDLADGV133 NSGQGLGIEI143 IGTLQLVLCV153 LATTDRRRRD 163 LGGSAPLAIG173 LSVALGHLLA183 IDYTGCGINP193 ARSFGSAVIT203 HNFSNHWIFW 213 VGPFIGGALA223 VLIYDFILAP233 RSSDLTDRVK243 VWTSGQ
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LEU81
2.385
LEU83
3.248
LEU84
2.768
LEU85
2.335
SER86
1.329
GLN88
1.330
ILE89
3.399
VAL214
4.315
PHE217
2.395
ILE218
3.148
ALA221
2.298
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Click to View More Binding Site Information of This Target and Ligand Pair |
References | Top | ||||
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REF 1 | Architecture of the human erythrocyte ankyrin-1 complex. Nat Struct Mol Biol. 2022 Jul;29(7):706-718. |
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