Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T43881 Target Info
Target Name Beta-defensin 4A (DEFB4A)
Synonyms hBD2; Skinantimicrobial peptide 1; SAP1; Defensin, beta 2; DEFB4B; DEFB4A; Betadefensin 4A; Betadefensin 2; BD2
Target Type Literature-reported Target
Gene Name DEFB4A
UniProt ID
DFB4A_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: [(2r)-2-Octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-Tris(Oxidanyl)-4,5-Diphosphonooxy-Cyclohexyl]oxy-Phosphoryl]oxy-Propyl] Octanoate Ligand Info
Structure Description Crystal structure of human beta-defensin 2 in complex with PIP2 PDB:6CS9
Method X-ray diffraction Resolution 1.85 Å Mutation No [1]
PDB Sequence
GIGDPVTCLK
10
SGAICHPVFC
20
PRRYKQIGTC
30
GLPGTKCCKK
40
P
Residue
Distance (Å)
PRO5
3.790
VAL6
4.015
LEU9
2.640
LYS10
2.940
SER11
3.682
Residue
Distance (Å)
GLY12
2.920
ALA13
4.797
CYS15
4.537
LEU32
4.194
LYS39
4.973
References  Top
REF 1 Human beta-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization. Sci Adv. 2018 Jul 25;4(7):eaat0979.

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