Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T43289 | Target Info | |||
| Target Name | Neuropsin (KLK8) | ||||
| Synonyms | hK8; UNQ283/PRO322; Tumor-associated differentially expressed gene-14 protein; Tumor-associated differentially expressed gene 14 protein; TADG14; Serine protease TADG-14; Serine protease 19; PRSS19; Ovasin; Neuropsin (M(r) 25032); NRPN; NP; Kallikrein-8; Kallikrein 8; KLK8 (neuropsin/ovasin) | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | KLK8 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-Methyl-2-Propanol | Ligand Info | |||||
| Structure Description | Kallikrein-related peptidase 8 leupeptin inhibitor complex | PDB:5MS4 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
VLGGHECQPH
25 SQPWQAALFQ35 GQQLLCGGVL46 VGGNWVLTAA56 HCKKPKYTVR66 LGDHSLQNKD 77 GPEQEIPVVQ87 SIPHPCYNSS95B DVEDHNHDLM104 LLQLRDQASL114 GSKVKPISLA 124 DHCTQPGQKC136 TVSGWGTVTS146 PRENFPDTLN156 CAEVKIFPQK166 KCEDAYPGQI 176 TDGMVCAGSS186 KGADTCQGDS195 GGPLVCDGAL209 QGITSWGSDP219 CGRSDKPGVY 228 TNICRYLDWI238 KKIIGSKG
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| Ligand Name: amino{[(4S)-4-amino-5,5-dihydroxypentyl]amino}methaniminium | Ligand Info | |||||
| Structure Description | Kallikrein-related peptidase 8 leupeptin inhibitor complex | PDB:5MS4 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
VLGGHECQPH
25 SQPWQAALFQ35 GQQLLCGGVL46 VGGNWVLTAA56 HCKKPKYTVR66 LGDHSLQNKD 77 GPEQEIPVVQ87 SIPHPCYNSS95B DVEDHNHDLM104 LLQLRDQASL114 GSKVKPISLA 124 DHCTQPGQKC136 TVSGWGTVTS146 PRENFPDTLN156 CAEVKIFPQK166 KCEDAYPGQI 176 TDGMVCAGSS186 KGADTCQGDS195 GGPLVCDGAL209 QGITSWGSDP219 CGRSDKPGVY 228 TNICRYLDWI238 KKIIGSKG
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. Sci Rep. 2018 Jul 16;8(1):10705. | ||||
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