Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T43031 Target Info
Target Name NIMA-related kinase 1 (NEK1)
Synonyms Serine/threonine-protein kinase Nek1; Renal carcinoma antigen NY-REN-55; NimA-related protein kinase 1; Never in mitosis A-related kinase 1; KIAA1901
Target Type Literature-reported Target
Gene Name NEK1
UniProt ID
NEK1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: [4-(2-Amino-4-methyl-thiazol-5-YL)-pyrimidin-2-YL]-(3-nitro-phenyl)-amine Ligand Info
Structure Description Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor. PDB:4B9D
Method X-ray diffraction Resolution 1.90 Å Mutation Yes [1]
PDB Sequence
HHHHTENLYF
-2
QSMEKYVRLQ
8
KIKAILVKST
24
EDGRQYVIKE
34
INISRMSSKE
44

REESRREVAV
54
LANMKHPNIV
64
QYRESFEENG
74
SLYIVMDYCE
84
GGDLFKRINA
94

QKGVLFQEDQ
104
ILDWFVQICL
114
ALKHVHDRKI
124
LHRDIKSQNI
134
FLTKDGTVQL
144

GDFGIARVLN
154
STVELARACI
164
GTPYYLSPEI
174
CENKPYNNKS
184
DIWALGCVLY
194

ELCTLKHAFE
204
AGSMKNLVLK
214
IISGSFPPVS
224
LHYSYDLRSL
234
VSQLFKRNPR
244

DRPSVNSILE
254
KGFIAKRIEK
264
FLSPQLIAEE
274
FCLKTFSKFG
284
Residue
Distance (Å)
ILE10
3.838
ALA18
3.220
VAL31
3.860
LYS33
4.761
VAL64
4.170
MET80
3.621
ASP81
3.147
TYR82
3.140
Residue
Distance (Å)
CYS83
2.815
GLU84
4.876
GLY86
3.558
ASP87
3.064
LYS90
4.123
GLN132
4.616
ASN133
4.414
PHE135
3.409
References  Top
REF 1 NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin. Sci Rep. 2017 Jul 14;7(1):5445.

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