Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T42932 | Target Info | |||
| Target Name | Toll-like receptor 1 (TLR1) | ||||
| Synonyms | Toll/interleukin-1 receptor-like protein; TIL; KIAA0012; CD281 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | TLR1 | ||||
| Biochemical Class | Toll-like receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (2r)-3-{[(2s)-3-Hydroxy-2-(Palmitoylamino)propyl]thio}propane-1,2-Diyl Dihexadecanoate | Ligand Info | |||||
| Structure Description | Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide | PDB:2Z7X | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
SEFLVDRSKN
34 GLIHVPKDLS44 QKTTILNISQ54 NYISELWTSD64 ILSLSKLRIL74 IISHNRIQYL 84 DISVFKFNQE94 LEYLDLSHNK104 LVKISCHPTV114 NLKHLDLSFN124 AFDALPICKE 134 FGNMSQLKFL144 GLSTTHLEKS154 SVLPIAHLNI164 SKVLLVLGET174 YGEKEDPEGL 184 QDFNTESLHI194 VFPTNKEFHF204 ILDVSVKTVA214 NLELSNIKCV224 LEDNKCSYFL 234 SILAKLQTNP244 KLSNLTLNNI254 ETTWNSFIRI264 LQLVWHTTVW274 YFSISNVKLQ 284 GQLDFRDFDY294 SGTSLKALSI304 HQVVSDVFGF314 PQSYIYEIFS324 NMNIKNFTVS 334 GTRMVHMLCP344 SKISPFLHLD354 FSNNLLTDTV364 FENCGHLTEL374 ETLILQMNQL 384 KELSKIAEMT394 TQMKSLQQLD404 ISQNSVSYDE414 KKGDCSWTKS424 LLSLNMSSNI 434 LTDTIFRCLP444 PRIKVLDLHS454 NKIKSIPKQV464 VKLEALQELN474 VASNQLKSVP 484 DGIFDRLTSL494 QKIWLHTNPW504 DCSCPRIDYL514 SRWLNKNSQK524 EQGSAKCSGS 534 GKPVRSIICP544
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007 Sep 21;130(6):1071-82. | ||||
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