Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T41702 | Target Info | |||
| Target Name | Casein kinase I gamma-1 (CSNK1G1) | ||||
| Synonyms | Casein kinase I isoform gamma-1; CKI-gamma 1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | CSNK1G1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Ligand Info | |||||
| Structure Description | Structure of Human Casein kinase 1 gamma-1 in complex with 2-(2- Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | PDB:2CMW | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [1] |
| PDB Sequence |
MRVGKKIGCG
53 NFGELRLGKN63 LYTNEYVAIK73 LEPIKSRAPQ83 LHLEYRFYKQ93 LGSAGEGLPQ 103 VYYFGPGKYN114 AMVLELLGPS124 LEDLFDLCDR134 TFTLKTVLMI144 AIQLLSRMEY 154 VHSKNLIYRD164 VKPENFLIGR174 QGNKKEHVIH184 IIDFGLAKEY194 IDPETKKHIP 204 YREHKSLGTA215 RYMSINTHLG225 KEQSRRDDLE235 ALGHMFMYFL245 RGSLPWQGLK 255 ADTLKERYQK265 IGDTKRNTPI275 EALCENFPEE285 MATYLRYVRR295 LDFFEKPDYE 305 YLRTLFTDLF315 EKKGYTFDYA325 YDWVGRPIPT335 PVGS
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VAL46
3.978
GLY47
3.623
ILE50
2.735
GLY51
3.399
CYS52
4.708
LEU58
3.444
LEU60
3.993
GLY61
3.346
LYS62
3.020
ASN63
3.326
LEU64
3.040
TYR65
3.521
VAL70
3.939
ALA71
3.802
ILE72
3.455
LYS73
4.524
TYR91
3.995
|
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| Ligand Name: 3-(Ethyldisulfanyl)-l-alanine | Ligand Info | |||||
| Structure Description | Structure of Human Casein kinase 1 gamma-1 in complex with 2-(2- Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | PDB:2CMW | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [1] |
| PDB Sequence |
MRVGKKIGCG
53 NFGELRLGKN63 LYTNEYVAIK73 LEPIKSRAPQ83 LHLEYRFYKQ93 LGSAGEGLPQ 103 VYYFGPGKYN114 AMVLELLGPS124 LEDLFDLCDR134 TFTLKTVLMI144 AIQLLSRMEY 154 VHSKNLIYRD164 VKPENFLIGR174 QGNKKEHVIH184 IIDFGLAKEY194 IDPETKKHIP 204 YREHKSLGTA215 RYMSINTHLG225 KEQSRRDDLE235 ALGHMFMYFL245 RGSLPWQGLK 255 ADTLKERYQK265 IGDTKRNTPI275 EALCENFPEE285 MATYLRYVRR295 LDFFEKPDYE 305 YLRTLFTDLF315 EKKGYTFDYA325 YDWVGRPIPT335 PVGS
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of Human Casein Kinase 1 Gamma-1 in Complex with 2-(2-Hydroxyethylamino)-6-(3-Chloroanilino)-9-Isopropylpurine (Casp Target) | ||||
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