Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40276 | Target Info | |||
| Target Name | Protein kinase C beta (PRKCB) | ||||
| Synonyms | Protein kinase C beta type; PRKCB1; PKCB; PKC-beta; PKC-B | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PRKCB | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: L-serine-O-phosphate | Ligand Info | |||||
| Structure Description | Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor | PDB:2I0E | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
LTDFNFLMVL
348 GKGSFGKVML358 SERKGTDELY368 AVKILKKDVV378 IQDDDVECTM388 VEKRVLALPG 398 KPPFLTQLHS408 CFQTMDRLYF418 VMEYVNGGDL428 MYHIQQVGRF438 KEPHAVFYAA 448 EIAIGLFFLQ458 SKGIIYRDLK468 LDNVMLDSEG478 HIKIADFGMC488 KENIWDGVTT 498 KFCGTPDYIA509 PEIIAYQPYG519 KSVDWWAFGV529 LLYEMLAGQA539 PFEGEDEDEL 549 FQSIMEHNVA559 YPKSMSKEAV569 AICKGLMTKH579 PGKRLGCGPE589 GERDIKEHAF 599 FRYIDWEKLE609 RKEIQPPYKP619 KACGRENFDR631 FFTRHPPVLP642 PDQEVIRNID 652 QSEFEGFFVN663 SEFLKP
|
|||||
|
|
||||||
| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor | PDB:2I0E | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
LTDFNFLMVL
348 GKGSFGKVML358 SERKGTDELY368 AVKILKKDVV378 IQDDDVECTM388 VEKRVLALPG 398 KPPFLTQLHS408 CFQTMDRLYF418 VMEYVNGGDL428 MYHIQQVGRF438 KEPHAVFYAA 448 EIAIGLFFLQ458 SKGIIYRDLK468 LDNVMLDSEG478 HIKIADFGMC488 KENIWDGVTT 498 KFCGTPDYIA509 PEIIAYQPYG519 KSVDWWAFGV529 LLYEMLAGQA539 PFEGEDEDEL 549 FQSIMEHNVA559 YPKSMSKEAV569 AICKGLMTKH579 PGKRLGCGPE589 GERDIKEHAF 599 FRYIDWEKLE609 RKEIQPPYKP619 KACGRENFDR631 FFTRHPPVLP642 PDQEVIRNID 652 QSEFEGFFVN663 SEFLKP
|
|||||
|
|
||||||
| Ligand Name: 3-{1-[3-(Dimethylamino)propyl]-2-Methyl-1h-Indol-3-Yl}-4-(2-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione | Ligand Info | |||||
| Structure Description | Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor | PDB:2I0E | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
LTDFNFLMVL
348 GKGSFGKVML358 SERKGTDELY368 AVKILKKDVV378 IQDDDVECTM388 VEKRVLALPG 398 KPPFLTQLHS408 CFQTMDRLYF418 VMEYVNGGDL428 MYHIQQVGRF438 KEPHAVFYAA 448 EIAIGLFFLQ458 SKGIIYRDLK468 LDNVMLDSEG478 HIKIADFGMC488 KENIWDGVTT 498 KFCGTPDYIA509 PEIIAYQPYG519 KSVDWWAFGV529 LLYEMLAGQA539 PFEGEDEDEL 549 FQSIMEHNVA559 YPKSMSKEAV569 AICKGLMTKH579 PGKRLGCGPE589 GERDIKEHAF 599 FRYIDWEKLE609 RKEIQPPYKP619 KACGRENFDR631 FFTRHPPVLP642 PDQEVIRNID 652 QSEFEGFFVN663 SEFLKP
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PDS or .PDS2 or .PDS3 or :3PDS;style chemicals stick;color identity;select .A:348 or .A:349 or .A:353 or .A:356 or .A:369 or .A:371 or .A:390 or .A:404 or .A:420 or .A:421 or .A:422 or .A:423 or .A:427 or .A:470 or .A:471 or .A:473 or .A:483 or .A:484; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor. Biochemistry. 2006 Nov 28;45(47):13970-81. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.