Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T38950 | Target Info | |||
| Target Name | Myeloid cell surface antigen CD33 (CD33) | ||||
| Synonyms | Siglec-3; Sialic acid-binding Ig-like lectin 3; SIGLEC3; Gp67 | ||||
| Target Type | Successful Target | ||||
| Gene Name | CD33 | ||||
| Biochemical Class | Immunoglobulin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside | Ligand Info | |||||
| Structure Description | Cell Surface Receptor with Bound Ligand at 1.75-A Resolution | PDB:6D4A | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [1] |
| PDB Sequence |
NFWLQVQESV
29 TVQEGLCVLV39 PCTFFHPIPY49 YDKNSPVHGY59 WFREGAIISR69 DSPVATNKLD 79 QEVQEETQGR89 FRLLGDPSRN99 NCSLSIVDAR109 RRDNGSYFFR119 MERGSTKYSY 129 KSPQLSVHVT139 DLT
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Abeta Phagocytosis. iScience. 2019 Sep 27;19:110-118. | ||||
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