Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T38187 | Target Info | |||
| Target Name | Mas-related gene 2 (MRGX2) | ||||
| Synonyms | Masrelated Gprotein coupled receptormember X2; MRGPRX2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | MRGPRX2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1 | PDB:7VV5 | ||||
| Method | Electron microscopy | Resolution | 2.76 Å | Mutation | No | [1] |
| PDB Sequence |
LLLLCGKETL
31 IPVFLILFIA41 LVGLVGNGFV51 LWLLGFRMRR61 NAFSVYVLSL71 AGADFLFLCF 81 QIINCLVYLS91 NFFCSISINF101 PSFFTTVMTC111 AYLAGLSMLS121 TVSTERCLSV 131 LWPIWYRCRR141 PRHLSAVVCV151 LLWALSLLLS161 ILEGKFCGFL171 FSDGDSGWCQ 181 TFDFITAAWL191 IFLFMVLCGS201 SLALLVRILC211 GSRGLPLTRL221 YLTILLTVLV 231 FLLCGLPFGI241 QWFLILWIWK251 DSDVLFCHIH261 PVSVVLSSLN271 SSANPIIYFF 281 VGSFRKQW
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| Ligand Name: 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine | Ligand Info | |||||
| Structure Description | Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1 | PDB:7VV5 | ||||
| Method | Electron microscopy | Resolution | 2.76 Å | Mutation | No | [1] |
| PDB Sequence |
LLLLCGKETL
31 IPVFLILFIA41 LVGLVGNGFV51 LWLLGFRMRR61 NAFSVYVLSL71 AGADFLFLCF 81 QIINCLVYLS91 NFFCSISINF101 PSFFTTVMTC111 AYLAGLSMLS121 TVSTERCLSV 131 LWPIWYRCRR141 PRHLSAVVCV151 LLWALSLLLS161 ILEGKFCGFL171 FSDGDSGWCQ 181 TFDFITAAWL191 IFLFMVLCGS201 SLALLVRILC211 GSRGLPLTRL221 YLTILLTVLV 231 FLLCGLPFGI241 QWFLILWIWK251 DSDVLFCHIH261 PVSVVLSSLN271 SSANPIIYFF 281 VGSFRKQW
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
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| REF 1 | Structure, function and pharmacology of human itch receptor complexes. Nature. 2021 Dec;600(7887):164-169. | ||||
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