Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T38093 Target Info
Target Name Cellular retinol binding protein III (RBP5)
Synonyms Retinol-binding protein 5; RBP5; HRBPiso; CRBP-III
Target Type Literature-reported Target
Gene Name RBP5
Biochemical Class Calycin family
UniProt ID
RET5_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Abnormal cannabidiol Ligand Info
Structure Description Crystal structure of human cellular retinol binding protein 3 in complex with abnormal-cannabidiol (abn-CBD) PDB:6E5W
Method X-ray diffraction Resolution 2.50 Å Mutation No [1]
PDB Sequence
PNLTGYYRFV
11
SQKNMEDYLQ
21
ALNISLAVRK
31
IALLLKPDKE
41
IEHQGNHMTV
51

RTLSTFRNYT
61
VQFDVGVEFE
71
EDLRSVDGRK
81
CQTIVTWEEE
91
HLVCVQKGEV
101

PNRGWRHWLE
111
GEMLYLELTA
121
RDAVCEQVFR
131
KVR
Residue
Distance (Å)
PHE10
4.231
GLN13
2.787
MET16
2.302
TYR19
3.483
LEU20
2.530
LEU23
4.988
ILE25
2.101
VAL29
3.007
ALA33
2.183
LEU34
4.491
LEU36
2.350
LYS37
4.678
PRO38
2.805
LYS40
3.268
THR53
2.201
LEU54
4.812
Residue
Distance (Å)
SER55
2.638
ARG58
2.671
ASN59
3.319
TYR60
2.535
GLU72
4.284
LEU74
3.141
SER76
3.540
VAL77
2.767
ASP78
4.660
GLN97
3.034
ARG104
3.774
TRP106
3.115
LEU117
4.543
LEU119
2.707
GLN128
1.996
References  Top
REF 1 Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1. ACS Chem Biol. 2019 Mar 15;14(3):434-448.

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