Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T37847 | Target Info | |||
| Target Name | Herpes simplex virus DNA polymerase UL30 (HSV UL30) | ||||
| Synonyms | HSV DNA polymerase catalytic subunit | ||||
| Target Type | Successful Target | ||||
| Gene Name | HSV UL30 | ||||
| Biochemical Class | DNA polymerase type-B | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: N-(4-chlorobenzyl)-1-methyl-6-(morpholinomethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide | Ligand Info | |||||
| Structure Description | HSV1 polymerase ternary complex with dsDNA and PNU-183792 | PDB:7LUF | ||||
| Method | X-ray diffraction | Resolution | 3.50 Å | Mutation | No | [1] |
| PDB Sequence |
TGPTQRHTYY
68 SECDEFRFIA78 PRVLDEDAPP88 EKRAGVHDGH98 LKRAPKVYCG108 GDERDVLRVG 118 SGGFWPRRSR128 LWGGVDHAPA138 GFNPTVTVFH148 VYDILENVEH158 AYGMRAAQFH 168 ARFMDAITPT178 GTVITLLGLT188 PEGHRVAVHV198 YGTRQYFYMN208 KEEVDRHLQC 218 RAPRDLCERM228 AAALRESPGA238 SFRGISADHF248 EAEVVERTDV258 YYYETRPALF 268 YRVYVRSGRV278 LSYLCDNFCP288 AIKKYEGGVD298 ATTRFILDNP308 GFVTFGWYRL 318 KPGRNNTLAQ328 PRAPMAFGTS338 SDVEFNCTAD348 NLAIEGGMSD358 LPAYKLMCFD 368 IACKAGGEDE378 LAFPVAGHPE388 DLVIQISCLL398 YDLSTTALEH408 VLLFSLGSCD 418 LPESHLNELA428 ARGLPTPVVL438 EFDSEFEMLL448 AFMTLVKQYG458 PEFVTGYNII 468 NFDWPFLLAK478 LTDIYKVPLD488 GYGRMNGRGV498 FRVWDIGQSH508 FQKRSKIKVN 518 GMVNIDMYGI528 ITDKIKLSSY538 KLNAVAEAVL548 KDKKKDLSYR558 DIPAYYAAGP 568 AQRGVIGEYC578 IQDSLLVGQL588 FFKFLPHLEL598 SAVARLAGIN608 ITRTIYDGQQ 618 IRVFTCLLRL628 ADQKGFILPD638 TQVGYQGARV701 HDPTSGFHVN711 PVVGFDFASL 721 YPSIIQAHNL731 CFSTLSLRAD741 AVAHLEAGKD751 YLEIEVGGRR761 LFFVKAHVRE 771 SLLSILLRDW781 LAMRKQIRSR791 IPQSSPEEAV801 LLDKQQAAIK811 VVCNSVYGFT 821 GVQHGLLPCL831 HVAATVTTIG841 REMLLATREY851 VHARWAAFEQ861 LLADFPEAAD 871 MRAPGPYSMR881 IIYGDTDSIF891 VLCRGLTAAG901 LTAMGDKMAS911 HISRALFLPP 921 IKLECEKTFT931 KLLLIAKKKY941 IGVIYGGKML951 IKGVDLVRKN961 NCAFINRTSR 971 ALVDLLFYDD981 TVSGAAAALA991 ERPAEEWLAR1001 PLPEGLQAFG1011 AVLVDAHRRI 1021 TDPERDIQDF1031 VLTAELSRHP1041 RAYTNKRLAH1051 LTVYYKLMAR1061 RAQVPSIKDR 1071 IPYVIVAQTR1081 EVEETVARLA1091 ALRELVSELA1143 EDPAYAIAHG1153 VALNTDYYFS 1163 HLLGAACVTF1173 KALFGNNAKI1183 TESLLKRFIP1193 EVWH
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase. Nat Commun. 2021 May 24;12(1):3040. | ||||
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