Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T37742 | Target Info | |||
| Target Name | Serum amyloid P-component (APCS) | ||||
| Synonyms | SAP; APCS; 9.5S alpha-1-glycoprotein | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | APCS | ||||
| Biochemical Class | Pentraxin family | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: CPHPC | Ligand Info | |||||
| Structure Description | Structure of CPHPC bound to Serum Amyloid P Component | PDB:4AVV | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [1] |
| PDB Sequence |
HTDLSGKVFV
10 FPRESVTDHV20 NLITPLEKPL30 QNFTLCFRAY40 SDLSRAYSLF50 SYNTQGRDNE 60 LLVYKERVGE70 YSLYIGRHKV80 TSKVIEKFPA90 PVHICVSWES100 SSGIAEFWIN 110 GTPLVKKGLR120 QGYFVEAQPK130 IVLGQEQDSY140 GGKFDRSQSF150 VGEIGDLYMW 160 DSVLPPENIL170 SAYQGTPLPA180 NILDWQALNY190 EIRGYVIIKP200 LVWV |
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| Ligand Name: O-Phosphoethanolamine | Ligand Info | |||||
| Structure Description | The structure of serum amyloid p component bound to phosphoethanolamine | PDB:3KQR | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [2] |
| PDB Sequence |
HTDLSGKVFV
10 FPRESVTDHV20 NLITPLEKPL30 QNFTLCFRAY40 SDLSRAYSLF50 SYNTQGRDNE 60 LLVYKERVGE70 YSLYIGRHKV80 TSKVIEKFPA90 PVHICVSWES100 SSGIAEFWIN 110 GTPLVKKGLR120 QGYFVEAQPK130 IVLGQEQDSY140 GGKFDRSQSF150 VGEIGDLYMW 160 DSVLPPENIL170 SAYQGTPLPA180 NILDWQALNY190 EIRGYVIIKP200 LVWV |
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| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | The structure of serum amyloid P component bound to 0-phospho- threonine | PDB:2W08 | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [3] |
| PDB Sequence |
HTDLSGKVFV
10 FPRESVTDHV20 NLITPLEKPL30 QNFTLCFRAY40 SDLSRAYSLF50 SYNTQGRDNE 60 LLVYKERVGE70 YSLYIGRHKV80 TSKVIEKFPA90 PVHICVSWES100 SSGIAEFWIN 110 GTPLVKKGLR120 QGYFVEAQPK130 IVLGQEQDSY140 GGKFDRSQSF150 VGEIGDLYMW 160 DSVLPPENIL170 SAYQGTPLPA180 NILDWQALNY190 EIRGYVIIKP200 LVWV |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TPO or .TPO2 or .TPO3 or :3TPO;style chemicals stick;color identity;select .A:58 or .A:59 or .A:62 or .A:64 or .A:66 or .A:74 or .A:79 or .A:136 or .A:137 or .A:138 or .A:148; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 5'-dAMP | Ligand Info | |||||
| Structure Description | DECAMERIC DAMP COMPLEX OF HUMAN SERUM AMYLOID P COMPONENT | PDB:1LGN | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [4] |
| PDB Sequence |
HTDLSGKVFV
10 FPRESVTDHV20 NLITPLEKPL30 QNFTLCFRAY40 SDLSRAYSLF50 SYNTQGRDNE 60 LLVYKERVGE70 YSLYIGRHKV80 TSKVIEKFPA90 PVHICVSWES100 SSGIAEFWIN 110 GTPLVKKGLR120 QGYFVEAQPK130 IVLGQEQDSY140 GGKFDRSQSF150 VGEIGDLYMW 160 DSVLPPENIL170 SAYQGTPLPA180 NILDWQALNY190 EIRGYVIIKP200 LVWV |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DA or .DA2 or .DA3 or :3DA;style chemicals stick;color identity;select .A:58 or .A:59 or .A:62 or .A:64 or .A:74 or .A:79 or .A:136 or .A:137 or .A:138 or .A:145 or .A:147 or .A:148; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-Acetyl-L-proline | Ligand Info | |||||
| Structure Description | Structure of N-Acetyl-L-Proline bound to Serum Amyloid P Component | PDB:4AVS | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [1] |
| PDB Sequence |
HTDLSGKVFV
10 FPRESVTDHV20 NLITPLEKPL30 QNFTLCFRAY40 SDLSRAYSLF50 SYNTQGRDNE 60 LLVYKERVGE70 YSLYIGRHKV80 TSKVIEKFPA90 PVHICVSWES100 SSGIAEFWIN 110 GTPLVKKGLR120 QGYFVEAQPK130 IVLGQEQDSY140 GGKFDRSQSF150 VGEIGDLYMW 160 DSVLPPENIL170 SAYQGTPLPA180 NILDWQALNY190 EIRGYVIIKP200 LVWV |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .N7P or .N7P2 or .N7P3 or :3N7P;style chemicals stick;color identity;select .A:58 or .A:59 or .A:62 or .A:64 or .A:74 or .A:136 or .A:137 or .A:138 or .A:148; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-acetyl-D-proline | Ligand Info | |||||
| Structure Description | Structure of N-Acetyl-D-Proline bound to serum amyloid P component | PDB:4AYU | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [1] |
| PDB Sequence |
HTDLSGKVFV
10 FPRESVTDHV20 NLITPLEKPL30 QNFTLCFRAY40 SDLSRAYSLF50 SYNTQGRDNE 60 LLVYKERVGE70 YSLYIGRHKV80 TSKVIEKFPA90 PVHICVSWES100 SSGIAEFWIN 110 GTPLVKKGLR120 QGYFVEAQPK130 IVLGQEQDSY140 GGKFDRSQSF150 VGEIGDLYMW 160 DSVLPPENIL170 SAYQGTPLPA180 NILDWQALNY190 EIRGYVIIKP200 LVWV |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .N8P or .N8P2 or .N8P3 or :3N8P;style chemicals stick;color identity;select .A:58 or .A:59 or .A:62 or .A:64 or .A:74 or .A:136 or .A:137 or .A:138 or .A:148; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane | Ligand Info | |||||
| Structure Description | Pentameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane. | PDB:2A3Y | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [5] |
| PDB Sequence |
HTDLSGKVFV
10 FPRESVTDHV20 NLITPLEKPL30 QNFTLCFRAY40 SDLSRAYSLF50 SYNTQGRDNE 60 LLVYKERVGE70 YSLYIGRHKV80 TSKVIEKFPA90 PVHICVSWES100 SSGIAEFWIN 110 GTPLVKKGLR120 QGYFVEAQPK130 IVLGQEQDSY140 GGKFDRSQSF150 VGEIGDLYMW 160 DSVLPPENIL170 SAYQGTPLPA180 NILDWQALNY190 EIRGYVIIKP200 LVWV |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CPJ or .CPJ2 or .CPJ3 or :3CPJ;style chemicals stick;color identity;select .A:58 or .A:59 or .A:62 or .A:64 or .A:74 or .A:136 or .A:138 or .A:148; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside | Ligand Info | |||||
| Structure Description | Serum Amyloid P Component co-crystallised with MOBDG at neutral pH | PDB:1GYK | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [6] |
| PDB Sequence |
HTDLSGKVFV
10 FPRESVTDHV20 NLITPLEKPL30 QNFTLCFRAY40 SDLSRAYSLF50 SYNTQGRDNE 60 LLVYKERVGE70 YSLYIGRHKV80 TSKVIEKFPA90 PVHICVSWES100 SSGIAEFWIN 110 GTPLVKKGLR120 QGYFVEAQPK130 IVLGQEQDSY140 GGKFDRSQSF150 VGEIGDLYMW 160 DSVLPPENIL170 SAYQGTPLPA180 NILDWQALNY190 EIRGYVIIKP200 LVWV |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CDG or .CDG2 or .CDG3 or :3CDG;style chemicals stick;color identity;select .A:58 or .A:59 or .A:62 or .A:64 or .A:74 or .A:79 or .A:136 or .A:137 or .A:138 or .A:148; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).Acta Crystallogr D Biol Crystallogr.2014 Aug;70(Pt 8):2232-40. | ||||
| REF 2 | Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. J Mol Recognit. 2011 Mar-Apr;24(2):371-7. | ||||
| REF 3 | Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7619-23. | ||||
| REF 4 | Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP. J Mol Biol. 1997 Jun 20;269(4):570-8. | ||||
| REF 5 | Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands. J Biol Chem. 2005 Sep 9;280(36):31999-2008. | ||||
| REF 6 | The structures of crystalline complexes of human serum amyloid P component with its carbohydrate ligand, the cyclic pyruvate acetal of galactose. J Mol Biol. 2002 Jul 26;320(5):1081-6. | ||||
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