Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T37371 Target Info
Target Name PAS domain-containing serine/threonine-protein kinase (PASK)
Synonyms hPASK; PASKIN; PAS-kinase; KIAA0135
Target Type Literature-reported Target
Gene Name PASK
UniProt ID
PASK_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: adenosine diphosphate Ligand Info
Structure Description Crystal structure of human PAS kinase bound to ADP PDB:3DLS
Method X-ray diffraction Resolution 2.30 Å Mutation No [1]
PDB Sequence
AVELEGLAAC
991
EGEYSQKYST
1001
MSPLGSGAFG
1011
FVWTAVDKEK
1021
NKEVVVKFIK
1031

KEKVLEDCWI
1041
EDPKLGKVTL
1051
EIAILSRVEH
1061
ANIIKVLDIF
1071
ENQGFFQLVM
1081

EKHGSGLDLF
1091
AFIDRHPRLD
1101
EPLASYIFRQ
1111
LVSAVGYLRL
1121
KDIIHRDIKD
1131

ENIVIAEDFT
1141
IKLIDFGSAA
1151
YLERGKLFYT
1161
FCGTIEYCAP
1171
EVLMGNPYRG
1181

PELEMWSLGV
1191
TLYTLVFEEN
1201
PFCELEETVE
1211
AAIHPPYLVS
1221
KELMSLVSGL
1231

LQPVPERRTT
1241
LEKLVTDPWV
1251
TQPVNLADYT
1261
WEEVF
Residue
Distance (Å)
LEU1005
3.675
GLY1006
3.442
SER1007
4.213
VAL1013
3.419
VAL1026
3.492
LYS1028
3.066
ILE1065
3.066
MET1081
3.925
GLU1082
2.929
LYS1083
3.781
Residue
Distance (Å)
HIS1084
3.259
GLY1087
2.976
LEU1088
4.670
ASP1089
3.041
GLU1132
2.920
ASN1133
3.536
VAL1135
3.490
ILE1145
3.678
ASP1146
2.880
References  Top
REF 1 Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation. J Biol Chem. 2010 Dec 24;285(52):41034-43.

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