Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T37046 Target Info
Target Name Biliverdin reductase A (BLVRA)
Synonyms Biliverdin-IX alpha-reductase; BVR A; BVR; BLVRA; BLVR
Target Type Successful Target
Gene Name BLVRA
Biochemical Class CH-CH donor oxidoreductase
UniProt ID
BIEA_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: NADP+ Ligand Info
Structure Description Crystal Structure of Human Biliverdin Reductase A PDB:2H63
Method X-ray diffraction Resolution 2.70 Å Mutation No [1]
PDB Sequence
MRKFGVVVVG
15
VGRAGSVRMR
25
DLRNPHPSSA
35
FLNLIGFVSR
45
RELGSIDGVQ
55

QISLEDALSS
65
QEVEVAYICS
75
ESSSHEDYIR
85
QFLNAGKHVL
95
VEYPMTLSLA
105

AAQELWELAE
115
QKGKVLHEEH
125
VELLMEEFAF
135
LKKEVVGKDL
145
LKGSLLFTAG
155

PLEEERFGFP
165
AFSGISRLTW
175
LVSLFGELSL
185
VSATLEERKQ
197
YMKMTVCLET
207

EKKSPLSWIE
217
EKGPGLKRNR
227
YLSFHFKSGS
237
LENVPNVGVN
247
KNIFLKDQNI
257

FVQKLLGQFS
267
EKELAAEKKR
277
ILHCLGLAEE
287
IQKY
Residue
Distance (Å)
VAL14
4.950
GLY15
3.061
VAL16
2.979
GLY17
3.588
ARG18
3.003
ALA19
2.605
GLY20
4.413
VAL43
4.396
SER44
2.649
ARG45
2.474
ARG46
2.888
LEU48
4.730
CYS74
3.417
SER75
3.384
Residue
Distance (Å)
GLU76
4.005
SER77
3.051
HIS80
3.062
TYR83
4.847
GLU97
3.275
TYR98
2.708
PRO99
3.809
GLU124
3.714
VAL126
4.807
ARG161
4.276
PHE162
3.470
ARG225
4.923
PHE251
4.036
References  Top
REF 1 Crystal Structure of Human Biliverdin Reductase A

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.