Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T36935 | Target Info | |||
| Target Name | Prostate specific antigen (KLK3) | ||||
| Synonyms | Seminin; Semenogelase; Prostate-specific antigen; PSA; P-30 antigen; Kallikrein-3; Gamma-seminoprotein; APS | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | KLK3 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose | Ligand Info | |||||
| Structure Description | Crystal structure of human prostate specific antigen complexed with an activating antibody | PDB:2ZCH | ||||
| Method | X-ray diffraction | Resolution | 2.83 Å | Mutation | No | [1] |
| PDB Sequence |
IVGGWECEKH
25 SQPWQVLVAS35 RGRAVCGGVL46 VHPQWVLTAA56 HCIRNKSVIL66 LGRHSLFHPE 77 DTGQVFQVSH87 SFPHPLYDMS95B LLKNRFLRPG96 DDSSHDLMLL106 RLSEPAELTD 116 AVKVMDLPTQ128 EPALGTTCYA138 SGWGSIEPEE148 FLTPKKLQCV158 DLHVISNDVC 168 AQVHPQKVTK178 FMLCAGRWTG186B GKSTCSGDSG196 GPLVCNGVLQ210 GITSWGSEPC 220 ALPERPSLYT229 KVVHYRKWIK239 DTIVANP
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody. J Mol Biol. 2008 Feb 29;376(4):1021-33. | ||||
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