Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T35063 | Target Info | |||
| Target Name | RAS-like protein KIR (GEM) | ||||
| Synonyms | RASlike protein KIR; GTPbinding protein GEM; GTPbinding mitogeninduced Tcell protein | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | GEM | ||||
| Biochemical Class | Small GTPase superfamily | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Guanosine-5'-Diphosphate | Ligand Info | |||||
| Structure Description | Crystal structure of the small GTPase Gem (GemDNDCaM) in complex to Mg.GDP | PDB:2CJW | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
MTYYRVVLIG 82 EQGVGKSTLA92 NIFAGVHDSE107 VLGEDTYERT117 LMVDGESATI127 ILLDMWENEW 141 LHDHCMQVGD151 AYLIVYSITD161 RASFEKASEL171 RIQLRRARQT181 EDIPIILVGN 191 KSDLVRREVS202 VSEGRAAVVF213 DKFIETSAAV224 QHNVKELFEG234 IVRQVRLRRD 244 SKEKNERRLA254 YQKR> Chain B EFGMTYYRVV 79 LIGEQGVGKS89 TLANIFAGVE111 DTYERTLMVD121 GESATIILLD131 MWENHDHMQV 149 GDAYLIVYSI159 TDRASFEKAS169 ELRIQLRRAR179 QTEDIPIILV189 GNKSDLVRRE 200 VSVSEGRAAV211 VFDCKFIETS221 AAVQHNVKEL231 FEGIVRQVRL241 RRDSKEKNER 251 RLAYQKRKES261
|
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|
|
GLU83[A]
3.890
GLN84[A]
3.694
GLY85[A]
2.708
VAL86[A]
3.327
GLY87[A]
3.089
LYS88[A]
2.731
SER89[A]
3.004
THR90[A]
2.726
ASP131[A]
4.747
GLU134[A]
4.875
ASN191[A]
3.201
LYS192[A]
3.112
SER193[A]
4.818
ASP194[A]
2.770
LEU195[A]
3.403
THR220[A]
4.642
SER221[A]
3.276
ALA222[A]
2.960
ALA223[A]
3.273
GLU83[B]
3.684
GLN84[B]
3.723
GLY85[B]
2.784
VAL86[B]
3.369
GLY87[B]
3.033
LYS88[B]
2.643
SER89[B]
2.994
THR90[B]
2.785
ASP131[B]
4.730
ASN191[B]
3.008
LYS192[B]
3.223
SER193[B]
4.878
ASP194[B]
2.634
LEU195[B]
3.462
THR220[B]
4.415
SER221[B]
3.437
ALA222[B]
2.607
ALA223[B]
3.240
|
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: S-(Dimethylarsenic)Cysteine | Ligand Info | |||||
| Structure Description | Crystal structure of the small GTPase Gem (GemDNDCaM) in complex to Mg.GDP | PDB:2CJW | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
MTYYRVVLIG 82 EQGVGKSTLA92 NIFAGVHDSE107 VLGEDTYERT117 LMVDGESATI127 ILLDMWENEW 141 LHDHCMQVGD151 AYLIVYSITD161 RASFEKASEL171 RIQLRRARQT181 EDIPIILVGN 191 KSDLVRREVS202 VSEGRAAVVF213 DKFIETSAAV224 QHNVKELFEG234 IVRQVRLRRD 244 SKEKNERRLA254 YQKR> Chain B EFGMTYYRVV 79 LIGEQGVGKS89 TLANIFAGVE111 DTYERTLMVD121 GESATIILLD131 MWENHDHMQV 149 GDAYLIVYSI159 TDRASFEKAS169 ELRIQLRRAR179 QTEDIPIILV189 GNKSDLVRRE 200 VSVSEGRAAV211 VFDCKFIETS221 AAVQHNVKEL231 FEGIVRQVRL241 RRDSKEKNER 251 RLAYQKRKES261
|
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|
|
GLU107[A]
1.336
VAL108[A]
3.260
LEU109[A]
3.303
GLY110[A]
4.371
THR113[A]
4.395
GLU115[A]
2.890
ILE128[A]
4.853
ILE159[A]
4.381
THR160[A]
3.349
PHE165[A]
3.294
GLU166[A]
4.884
ALA168[A]
3.659
SER169[A]
3.592
ARG172[A]
4.340
ARG176[A]
4.363
ILE186[A]
3.295
ILE187[A]
4.923
LEU188[A]
3.683
LEU195[A]
3.115
VAL196[A]
3.256
ARG197[A]
1.332
ARG199[A]
1.332
GLU200[A]
3.349
GLU205[A]
3.062
GLY206[A]
3.302
ARG207[A]
3.295
ALA208[A]
1.341
ALA210[A]
1.337
VAL211[A]
3.333
VAL212[A]
3.461
PHE213[A]
2.849
ASP214[A]
1.329
LYS216[A]
1.327
PHE217[A]
4.178
VAL79[B]
3.648
LEU130[B]
4.938
MET132[B]
3.418
TRP133[B]
3.700
HIS143[B]
3.374
ASP144[B]
3.331
HIS145[B]
1.330
MET147[B]
1.334
GLN148[B]
3.185
VAL149[B]
3.426
GLY150[B]
4.437
TYR153[B]
2.608
ILE159[B]
4.573
THR160[B]
3.593
PHE165[B]
3.575
SER169[B]
4.675
LEU195[B]
3.152
VAL196[B]
3.195
ARG197[B]
1.332
ARG199[B]
1.333
GLU200[B]
3.605
SER204[B]
4.893
GLU205[B]
2.930
GLY206[B]
3.511
ARG207[B]
3.411
ALA208[B]
1.335
ALA210[B]
1.331
VAL211[B]
3.274
VAL212[B]
3.113
PHE213[B]
2.684
ASP214[B]
4.760
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Biochemical and structural characterization of the gem GTPase. J Biol Chem. 2007 Jan 19;282(3):1905-15. | ||||
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