Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T34287 | Target Info | |||
| Target Name | Candida Mannose-6-phosphate isomerase (Candi PMI1) | ||||
| Synonyms | Phosphomannose isomerase; Phosphohexomutase; PMI1; PMI | ||||
| Target Type | Successful Target | ||||
| Gene Name | Candi PMI1 | ||||
| Biochemical Class | Intramolecular oxidoreductases | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (2S,3R,4R)-2,3,4-Trihydroxy-5-(phosphonooxy)valerohydrazide | Ligand Info | |||||
| Structure Description | Crystal structure of candida albicans phosphomannose isomerase in complex with inhibitor | PDB:5NW7 | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [1] |
| PDB Sequence |
SSEKLFRIQC
11 GYQNYDWGKI21 GSSSAVAQFV31 HNSDPSITID41 ETKPYAELWM51 GTHPSVPSKA 61 IDLNNQTLRD71 LVTAKPQEYL81 GESIITKFGS91 SKELPFLFKV101 LSIEKVLSIQ 111 AHPDKKLGAQ121 LHAADPKNYP131 DDNHKPEMAI141 AVTDFEGFCG151 FKPLDQLAKT 161 LATVPELNEI171 IGQELVDEFI181 SGIKLPAEVG191 SQDDVNNRKL201 LQKVFGKLMN 211 TDDDVIKQQT221 AKLLERTDRE231 PQVFKDIDSR241 LPELIQRLNK251 QFPNDIGLFC 261 GCLLLNHVGL271 NKGEAMFLQA281 KDPHAYISGD291 IIECMAASDN301 VVRAGFTPKF 311 KDVKNLVEML321 TYSYESVEKQ331 KMPLQEFPRS341 KGDAVKSVLY351 DPPIAEFSVL 361 QTIFDKSKGG371 KQVIEGLNGP381 SIVIATNGKG391 TIQITGDDST401 KQKIDTGYVF 411 FVAPGSSIEL421 TADSANQDQD431 FTTYRAFVEA441
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of phosphomannose isomerase from Candida?albicans complexed with 5-phospho-d-arabinonhydrazide. FEBS Lett. 2018 May;592(10):1667-1680. | ||||
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