Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T34239 | Target Info | |||
| Target Name | Protoporphyrinogen oxidase (PPOX) | ||||
| Synonyms | PPO | ||||
| Target Type | Successful Target | ||||
| Gene Name | PPOX | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Flavin-Adenine Dinucleotide | Ligand Info | |||||
| Structure Description | Structure of human protoporphyrinogen IX oxidase | PDB:3NKS | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
GRTVVVLGGG
11 ISGLAASYHL21 SRAPCPPKVV31 LVESSERLGG41 WIRSVRGPNG51 AIFELGPRGI 61 RPAGALGART71 LLLVSELGLD81 SEVLPVRGDH91 PAAQNRFLYV101 GGALHALPTG 111 LRGPSPPFSK124 PLFWAGLREL134 TKPRGKEPDE144 TVHSFAQRRL154 GPEVASLAMD 164 SLCRGVFAGN174 SRELSIRSCF184 PSLFQAEQTH194 RSILLGLLLG204 QPDSALIRQA 219 LAERWSQWSL229 RGGLEMLPQA239 LETHLTSRGV249 SVLRGQPVCG259 LSLQAEGRWK 269 VSLRDSSLEA279 DHVISAIPAS289 VLSELLPAEA299 APLARALSAI309 TAVSVAVVNL 319 QYQGAHLPVQ329 GFGHLVPSSE339 DPGVLGIVYD349 SVAFPEQDGS359 PPGLRVTVML 369 GGSWLQTLEA379 SGCVLSQELF389 QQRAQEAAAT399 QLGLKEMPSH409 CLVHLHKNCI 419 PQYTLGHWQK429 LESARQFLTA439 HRLPLTLAGA449 SYEGVAVNDC459 IESGRQAAVS 469 VLGTE
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LEU8
4.689
GLY9
3.357
GLY10
4.122
GLY11
3.486
ILE12
3.555
SER13
3.039
GLY14
4.454
VAL33
3.075
GLU34
2.666
SER35
3.000
SER36
4.260
GLY40
4.246
GLY41
3.220
TRP42
2.966
ILE43
4.230
LEU56
3.637
GLY57
3.462
PRO58
3.252
ARG59
3.637
GLY60
3.678
GLN255
4.191
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Acifluorfen | Ligand Info | |||||
| Structure Description | Structure of human protoporphyrinogen IX oxidase | PDB:3NKS | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
GRTVVVLGGG
11 ISGLAASYHL21 SRAPCPPKVV31 LVESSERLGG41 WIRSVRGPNG51 AIFELGPRGI 61 RPAGALGART71 LLLVSELGLD81 SEVLPVRGDH91 PAAQNRFLYV101 GGALHALPTG 111 LRGPSPPFSK124 PLFWAGLREL134 TKPRGKEPDE144 TVHSFAQRRL154 GPEVASLAMD 164 SLCRGVFAGN174 SRELSIRSCF184 PSLFQAEQTH194 RSILLGLLLG204 QPDSALIRQA 219 LAERWSQWSL229 RGGLEMLPQA239 LETHLTSRGV249 SVLRGQPVCG259 LSLQAEGRWK 269 VSLRDSSLEA279 DHVISAIPAS289 VLSELLPAEA299 APLARALSAI309 TAVSVAVVNL 319 QYQGAHLPVQ329 GFGHLVPSSE339 DPGVLGIVYD349 SVAFPEQDGS359 PPGLRVTVML 369 GGSWLQTLEA379 SGCVLSQELF389 QQRAQEAAAT399 QLGLKEMPSH409 CLVHLHKNCI 419 PQYTLGHWQK429 LESARQFLTA439 HRLPLTLAGA449 SYEGVAVNDC459 IESGRQAAVS 469 VLGTE
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insight into human variegate porphyria disease. FASEB J. 2011 Feb;25(2):653-64. | ||||
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