Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32780 | Target Info | |||
| Target Name | Asialoglycoprotein receptor 1 (ASGR1) | ||||
| Synonyms | Hepatic lectin H1; HL-1; C-type lectin domain family 4 member H1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ASGR1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: N-[(1s,2r,3r,4r,5s)-2,3-Dihydroxy-1-(Hydroxymethyl)-6,8-Dioxabicyclo[3.2.1]octan-4-Yl]acetamide | Ligand Info | |||||
| Structure Description | Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic | PDB:5JQ1 | ||||
| Method | X-ray diffraction | Resolution | 1.83 Å | Mutation | No | [1] |
| PDB Sequence |
TCCPVNWVEH
160 ERSCYWFSRS170 GKAWADADNY180 CRLEDAHLVV190 VTSWEEQKFV200 QHHIGPVNTW 210 MGLHDQNGPW220 KWVDGTDYET230 GFKNWRPEQP240 DDWYGHGLGG250 GEDCAHFTDD 260 GRWNDDVCQR270 PYRWVCETEL280
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| Ligand Name: 5-[(2~{R},3~{R},4~{R},5~{R},6~{R})-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-~{N}-[3-(propanoylamino)propyl]pentanamide | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF ASGPR 1 IN COMPLEX WITH GN-A. | PDB:6YAU | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [2] |
| PDB Sequence |
CCPVNWVEHE
161 RSCYWFSRSG171 KAWADADNYC181 RLEDAHLVVV191 TSWEEQKFVQ201 HHIGPVNTWM 211 GLHDQNGPWK221 WVDGTDYETG231 FKNWRPEQPD241 DWYGHGLGGG251 EDCAHFTDDG 261 RWNDDVCQRP271 YRWVCETEL
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor. J Am Chem Soc. 2017 Mar 8;139(9):3528-3536. | ||||
| REF 2 | Triantennary GalNAc Molecular Imaging Probes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic Steatohepatitis. Adv Sci (Weinh). 2020 Nov 9;7(24):2002997. | ||||
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