Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T32262 | Target Info | |||
Target Name | Calcitonin gene-related peptide receptor (CGRPR) | ||||
Synonyms | Calcitonin receptor-like receptor; Calcitonin gene-related peptide type 1 receptor; CGRPR; CGRP type 1 receptor | ||||
Target Type | Successful Target | ||||
Gene Name | CALCRL | ||||
Biochemical Class | GPCR secretin | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Olcegepant | Ligand Info | |||||
Structure Description | Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism | PDB:3N7S | ||||
Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
PDB Sequence |
IQLGVTRNKI
41 MTAQYECYQK51 IMQDPIEGVY64 CNRTWDGWLC74 WNDVAAGTES84 MQLCPDYFQD 94 FDPSEKVTKI104 CDQDGNWFRH114 PASNRTWTNY124 TQCN
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References | Top | ||||
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REF 1 | Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure. 2010 Sep 8;18(9):1083-93. |
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