Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31956 | Target Info | |||
| Target Name | Glutamyl aminopeptidase (ENPEP) | ||||
| Synonyms | ENPEP; EAP; Differentiation antigen gp160; Aminopeptidase A; APA | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ENPEP | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Arginine | Ligand Info | |||||
| Structure Description | Crystal structure of human aminopeptidase A complexed with arginine | PDB:4KX9 | ||||
| Method | X-ray diffraction | Resolution | 2.25 Å | Mutation | Yes | [1] |
| PDB Sequence |
DICPASEDES
85 GQWKNFRLPD95 FVNPVHYDLH105 VKPLLEEDTY115 TGTVSISINL125 SAPTRYLWLH 135 LRETRITRLP145 ELKRPSGDQV155 QVRRCFEYKK165 QEYVVVEAEE175 ELTPSSGDGL 185 YLLTMEFAGW195 LNGSLVGFYR205 TTYTENGRVK215 SIAATDHEPT225 DARKSFPCFD 235 EPNKKATYTI245 SITHPKEYGA255 LSNMPVAKEE265 SVDDKWTRTT275 FEKSVPMSTY 285 LVCFAVHQFD295 SVKRISNSGK305 PLTIYVQPEQ315 KHTAEYAANI325 TKSVFDYFEE 335 YFAMNYSLPK345 LDKIAIPDFG355 TGAMENWGLI365 TYRETNLLYD375 PKESASSNQQ 385 RVATVVAHEL395 VHQWFGNIVT405 MDWWEDLWLN415 EGFASFFEFL425 GVNHAETDWQ 435 MRDQMLLEDV445 LPVQEDDSLM455 SSHPIIVTVT465 TPDEITSVFD475 GISYSKGSSI 485 LRMLEDWIKP495 ENFQKGCQMY505 LEKYQFKNAK515 TSDFWAALEE525 ASRLPVKEVM 535 DTWTRQMGYP545 VLNVNGVKNI555 TQKRFLLDPR565 ANPSQPPSDL575 GYTWNIPVKW 585 TEDNITSSVL595 FNRSEKEGIT605 LNSGNAFLKI619 NPDHIGFYRV629 NYEVATWDSI 639 ATALSLNHKT649 FSSADRASLI659 DDAFALARAQ669 LLDYKVALNL679 TKYLKREENF 689 LPWQRVISAV699 TYIISMFEDD709 KELYPMIEEY719 FQGQVKPIAD729 SLGWNDAGDH 739 VTKLLRSSVL749 GFACKMGDRE759 ALNNASSLFE769 QWLNGTVSLP779 VNLRLLVYRY 789 GMQNSGNEIS799 WNYTLEQYQK809 TSLAQEKEKL819 LYGLASVKNV829 TLLSRYLDLL 839 KDTNLIKTQD849 VFTVIRYISY859 NSYGKNMAWN869 WIQLNWDYLV879 NRYTLNNRNL 889 GRIVTIAEPF899 NTELQLWQME909 SFFAKYPQAG919 AGEKPREQVL929 ETVKNNIEWL 939 KQHRNTIREW949 FFNLL
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| Ligand Name: Bestatin | Ligand Info | |||||
| Structure Description | Crystal structure of human aminopeptidase A complexed with bestatin | PDB:4KXB | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
DICPASEDES
85 GQWKNFRLPD95 FVNPVHYDLH105 VKPLLEEDTY115 TGTVSISINL125 SAPTRYLWLH 135 LRETRITRLP145 ELKRPSGDQV155 QVRRCFEYKK165 QEYVVVEAEE175 ELTPSSGDGL 185 YLLTMEFAGW195 LNGSLVGFYR205 TTYTENGRVK215 SIAATDHEPT225 DARKSFPCFD 235 EPNKKATYTI245 SITHPKEYGA255 LSNMPVAKEE265 SVDDKWTRTT275 FEKSVPMSTY 285 LVCFAVHQFD295 SVKRISNSGK305 PLTIYVQPEQ315 KHTAEYAANI325 TKSVFDYFEE 335 YFAMNYSLPK345 LDKIAIPDFG355 TGAMENWGLI365 TYRETNLLYD375 PKESASSNQQ 385 RVATVVAHEL395 VHQWFGNIVT405 MDWWEDLWLN415 EGFASFFEFL425 GVNHAETDWQ 435 MRDQMLLEDV445 LPVQEDDSLM455 SSHPIIVTVT465 TPDEITSVFD475 GISYSKGSSI 485 LRMLEDWIKP495 ENFQKGCQMY505 LEKYQFKNAK515 TSDFWAALEE525 ASRLPVKEVM 535 DTWTRQMGYP545 VLNVNGVKNI555 TQKRFLLDPR565 ANPSQPPSDL575 GYTWNIPVKW 585 TEDNITSSVL595 FNRSEKEGIT605 LNSGNAFLKI619 NPDHIGFYRV629 NYEVATWDSI 639 ATALSLNHKT649 FSSADRASLI659 DDAFALARAQ669 LLDYKVALNL679 TKYLKREENF 689 LPWQRVISAV699 TYIISMFEDD709 KELYPMIEEY719 FQGQVKPIAD729 SLGWNDAGDH 739 VTKLLRSSVL749 GFACKMGDRE759 ALNNASSLFE769 QWLNGTVSLP779 VNLRLLVYRY 789 GMQNSGNEIS799 WNYTLEQYQK809 TSLAQEKEKL819 LYGLASVKNV829 TLLSRYLDLL 839 KDTNLIKTQD849 VFTVIRYISY859 NSYGKNMAWN869 WIQLNWDYLV879 NRYTLNNRNL 889 GRIVTIAEPF899 NTELQLWQME909 SFFAKYPQAG919 AGEKPREQVL929 ETVKNNIEWL 939 KQHRNTIREW949 FFNLL
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| Ligand Name: L-aspartic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human aminopeptidase A complexed with aspartate and calcium | PDB:4KXA | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
DICPASEDES
85 GQWKNFRLPD95 FVNPVHYDLH105 VKPLLEEDTY115 TGTVSISINL125 SAPTRYLWLH 135 LRETRITRLP145 ELKRPSGDQV155 QVRRCFEYKK165 QEYVVVEAEE175 ELTPSSGDGL 185 YLLTMEFAGW195 LNGSLVGFYR205 TTYTENGRVK215 SIAATDHEPT225 DARKSFPCFD 235 EPNKKATYTI245 SITHPKEYGA255 LSNMPVAKEE265 SVDDKWTRTT275 FEKSVPMSTY 285 LVCFAVHQFD295 SVKRISNSGK305 PLTIYVQPEQ315 KHTAEYAANI325 TKSVFDYFEE 335 YFAMNYSLPK345 LDKIAIPDFG355 TGAMENWGLI365 TYRETNLLYD375 PKESASSNQQ 385 RVATVVAHEL395 VHQWFGNIVT405 MDWWEDLWLN415 EGFASFFEFL425 GVNHAETDWQ 435 MRDQMLLEDV445 LPVQEDDSLM455 SSHPIIVTVT465 TPDEITSVFD475 GISYSKGSSI 485 LRMLEDWIKP495 ENFQKGCQMY505 LEKYQFKNAK515 TSDFWAALEE525 ASRLPVKEVM 535 DTWTRQMGYP545 VLNVNGVKNI555 TQKRFLLDPR565 ANPSQPPSDL575 GYTWNIPVKW 585 TEDNITSSVL595 FNRSEKEGIT605 LNSGNAFLKI619 NPDHIGFYRV629 NYEVATWDSI 639 ATALSLNHKT649 FSSADRASLI659 DDAFALARAQ669 LLDYKVALNL679 TKYLKREENF 689 LPWQRVISAV699 TYIISMFEDD709 KELYPMIEEY719 FQGQVKPIAD729 SLGWNDAGDH 739 VTKLLRSSVL749 GFACKMGDRE759 ALNNASSLFE769 QWLNGTVSLP779 VNLRLLVYRY 789 GMQNSGNEIS799 WNYTLEQYQK809 TSLAQEKEKL819 LYGLASVKNV829 TLLSRYLDLL 839 KDTNLIKTQD849 VFTVIRYISY859 NSYGKNMAWN869 WIQLNWDYLV879 NRYTLNNRNL 889 GRIVTIAEPF899 NTELQLWQME909 SFFAKYPQAG919 AGEKPREQVL929 ETVKNNIEWL 939 KQHRNTIREW949 FFNLL
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insights into central hypertension regulation by human aminopeptidase A. J Biol Chem. 2013 Aug 30;288(35):25638-25645. | ||||
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