Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T31621 Target Info
Target Name Fibroblast growth factor-2 (FGF2)
Synonyms bFGF; Heparin-binding growth factor 2; HBGF-2; Fibroblast growth factor 2; FGFB; FGF-2; Basic fibroblast growth factor
Target Type Successful Target
Gene Name FGF2
Biochemical Class Growth factor
UniProt ID
FGF2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: D-myo-inositol 1,4,5-trisphosphate Ligand Info
Structure Description PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to facilitate the unconventional oligomerization-dependent secretion process as revealed by a combined FTIR/NMR/X-ray study PDB:5X1O
Method X-ray diffraction Resolution 1.90 Å Mutation No [1]
PDB Sequence
KDPKRLYCKN
27
GGFFLRIHPD
37
GRVDGVREKS
47
DPHIKLQLQA
57
EERGVVSIKG
67

VCANRYLAMK
77
EDGRLLASKC
87
VTDECFFFER
97
LESNNYNTYR
107
SRKYTSWYVA
117

LKRTGQYKLG
127
SKTGPGQKAI
137
LFLPMSA
Residue
Distance (Å)
ARG39
4.683
VAL40
4.010
ASP41
4.766
ARG72
4.919
ALA75
4.629
LYS77
2.432
GLU78
3.046
ASP79
4.613
ARG81
2.190
Residue
Distance (Å)
LEU82
2.914
LEU83
3.299
ALA84
4.585
SER85
2.539
GLU91
3.626
GLN123
2.985
TYR124
2.292
LEU126
4.471
References  Top
REF 1 PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to facilitate the unconventional oligomerization-dependent secretion process as revealed by a combined FTIR/NMR/X-ray study

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