Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31186 | Target Info | |||
| Target Name | Eukaryotic initiation factor 4E (EIF4E) | ||||
| Synonyms | eIF4F 25 kDa subunit; eIF4E; eIF-4F 25 kDa subunit; eIF-4E; Eukaryotic translation initiation factor 4E; EIF4F; EIF4EL1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | EIF4E | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 7-Methyl-Gpppa | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GPPPA | PDB:1IPB | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
EVANPEHYIK
36 HPLQNRWALW46 FFKNDKSKTW56 QANLRLISKF66 DTVEDFWALY76 NHIQLSSNLM 86 PGCDYSLFKD96 GIEPMWEDEK106 NKRGGRWLIT116 LNKQQRRSDL126 DRFWLETLLC 136 LIGESFDDYS146 DDVCGAVVNV156 RAKGDKIAIW166 TTECENREAV176 THIGRVYKER 186 LGLPPKIVIG196 YQSHADTATK206 SGSTTKNRFV216 V
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TRP56
3.516
GLN57
3.106
ASP90
4.527
PRO100
4.311
MET101
3.064
TRP102
2.739
GLU103
2.827
ARG112
4.737
ASN155
4.294
ARG157
2.763
LYS162
2.860
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 7-Methyl-Guanosine-5'-Triphosphate | Ligand Info | |||||
| Structure Description | The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G | PDB:4TPW | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [2] |
| PDB Sequence |
HYIKHPLQNR
42 WALWFFKNDK52 SKTWQANLRL62 ISKFDTVEDF72 WALYNHIQLS82 SNLMPGCDYS 92 LFKDGIEPMW102 EDEKNKRGGR112 WLITLNKQQR122 RSDLDRFWLE132 TLLCLIGESF 142 DDYSDDVCGA152 VVNVRAKGDK162 IAIWTTECEN172 REAVTHIGRV182 YKERLGLPPK 192 IVIGYQSHAD202 TATKSGSTTK212 NRFVV
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ASN50
4.306
LYS52
4.722
TRP56
2.703
GLN57
3.380
ASP90
4.527
PRO100
4.503
MET101
2.573
TRP102
1.965
GLU103
2.352
ARG112
3.861
ASN155
3.997
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 7n-Methyl-8-Hydroguanosine-5'-Diphosphate | Ligand Info | |||||
| Structure Description | The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G | PDB:4TQC | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [2] |
| PDB Sequence |
IKHPLQNRWA
44 LWFFKNDKSK54 TWQANLRLIS64 KFDTVEDFWA74 LYNHIQLSMP87 GCDYSLFKDG 97 IEPMWEDEKN107 KRGGRWLITL117 NKQQRRSDLD127 RFWLETLLCL137 IGESFDDYSD 147 DVCGAVVNVR157 AKGDKIAIWT167 TECENREAVT177 HIGRVYKERL187 GLPPKIVIGY 197 QSHADTATKS207 KNRFVV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .M7G or .M7G2 or .M7G3 or :3M7G;style chemicals stick;color identity;select .A:52 or .A:56 or .A:57 or .A:90 or .A:100 or .A:101 or .A:102 or .A:103 or .A:112 or .A:155 or .A:157 or .A:162 or .A:166 or .A:203 or .A:204; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: [[(2R,3S,4R,5R)-5-(6-Amino-3-methyl-4-oxo-5H-imidazo[4,5-C]pyridin-1-YL)-3,4-dihydroxy-oxolan-2-YL]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate | Ligand Info | |||||
| Structure Description | eIF4E in Complex with a Disulphide-Free Autonomous VH Domain | PDB:7D6Y | ||||
| Method | X-ray diffraction | Resolution | 1.67 Å | Mutation | No | [3] |
| PDB Sequence |
EHYIKHPLQN
41 RWALWFFKND51 KSKTWQANLR61 LISKFDTVED71 FWALYNHIQL81 SSNLMPGCDY 91 SLFKDGIEPM101 WEDEKNKRGG111 RWLITLNKQQ121 RRSDLDRFWL131 ETLLCLIGES 141 FDDYSDDVCG151 AVVNVRAKGD161 KIAIWTTECE171 NREAVTHIGR181 VYKERLGLPP 191 KIVIGYQSHA201 DTATNRFVV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MGO or .MGO2 or .MGO3 or :3MGO;style chemicals stick;color identity;select .A:56 or .A:90 or .A:100 or .A:101 or .A:102 or .A:103 or .A:112 or .A:155 or .A:157 or .A:159 or .A:162 or .A:166; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: N-[[(2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-1,1,1-trifluoromethanesulfonamide | Ligand Info | |||||
| Structure Description | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | PDB:5EI3 | ||||
| Method | X-ray diffraction | Resolution | 1.71 Å | Mutation | No | [4] |
| PDB Sequence |
EVANPEHYIK
36 HPLQNRWALW46 FFKNDKSKTW56 QANLRLISKF66 DTVEDFWALY76 NHIQLSSNLM 86 PGCDYSLFKD96 GIEPMWEDEK106 NKRGGRWLIT116 LNKQQRRSDL126 DRFWLETLLC 136 LIGESFDDYS146 DDVCGAVVNV156 RAKGDKIAIW166 TTECENREAV176 THIGRVYKER 186 LGLPPKIVIG196 YQSHADTATK206 SGSTTKNRFV216 V
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5O8 or .5O82 or .5O83 or :35O8;style chemicals stick;color identity;select .A:56 or .A:57 or .A:100 or .A:101 or .A:102 or .A:103 or .A:112 or .A:166 or .A:200 or .A:203 or .A:204; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: P-Fluoro-7-Benzyl Guanine Monophosphate | Ligand Info | |||||
| Structure Description | Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | PDB:2V8Y | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [5] |
| PDB Sequence |
EHYIKHPLQN
41 RWALWFFKND51 KSKTWQANLR61 LISKFDTVED71 FWALYNHIQL81 SSNLMPGCDY 91 SLFKDGIEPM101 WEDEKNKRGG111 RWLITLNKQQ121 RRSDLDRFWL131 ETLLCLIGES 141 FDDYSDDVCG151 AVVNVRAKGD161 KIAIWTTECE171 NREAVTHIGR181 VYKERLGLPP 191 KIVIGYQSHA201 DTATTKNRFV216 V
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MGV or .MGV2 or .MGV3 or :3MGV;style chemicals stick;color identity;select .A:56 or .A:90 or .A:100 or .A:101 or .A:102 or .A:103 or .A:112 or .A:155 or .A:157 or .A:162 or .A:166 or .A:200 or .A:203; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 7-Benzyl Guanine Monophosphate | Ligand Info | |||||
| Structure Description | Crystallographic and mass spectrometric characterisation of eIF4E with N7-cap derivatives | PDB:2V8X | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [5] |
| PDB Sequence |
EHYIKHPLQN
41 RWALWFFKND51 KSKTWQANLR61 LISKFDTVED71 FWALYNHIQL81 SSNLMPGCDY 91 SLFKDGIEPM101 WEDEKNKRGG111 RWLITLNKQQ121 RRSDLDRFWL131 ETLLCLIGES 141 FDDYSDDVCG151 AVVNVRAKGD161 KIAIWTTECE171 NREAVTHIGR181 VYKERLGLPP 191 KIVIGYQSHA201 DTATTKNRFV216 V
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MGQ or .MGQ2 or .MGQ3 or :3MGQ;style chemicals stick;color identity;select .A:56 or .A:90 or .A:100 or .A:101 or .A:102 or .A:103 or .A:112 or .A:155 or .A:157 or .A:162 or .A:166 or .A:200 or .A:203; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[[(2~{r},3~{s},4~{r},5~{r})-5-[2-Azanyl-7-[(3-Chlorophenyl)methyl]-6-Oxidanylidene-1~{h}-Purin-7-Ium-9-Yl]-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]-4-Oxidanyl-Cyclobut-3-Ene-1,2-Dione | Ligand Info | |||||
| Structure Description | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | PDB:5EHC | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [4] |
| PDB Sequence |
EVANPEHYIK
36 HPLQNRWALW46 FFKNDKSKTW56 QANLRLISKF66 DTVEDFWALY76 NHIQLSSNLM 86 PGCDYSLFKD96 GIEPMWEDEK106 NKRGGRWLIT116 LNKQQRRSDL126 DRFWLETLLC 136 LIGESFDDYS146 DDVCGAVVNV156 RAKGDKIAIW166 TTECENREAV176 THIGRVYKER 186 LGLPPKIVIG196 YQSHADTATT211 KNRFVV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5NX or .5NX2 or .5NX3 or :35NX;style chemicals stick;color identity;select .A:48 or .A:56 or .A:57 or .A:90 or .A:100 or .A:101 or .A:102 or .A:103 or .A:112 or .A:155 or .A:157 or .A:162 or .A:166 or .A:200 or .A:203 or .A:204; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[[(2~{r},3~{s},4~{r},5~{r})-5-(2-Azanyl-7-Methyl-6-Oxidanylidene-1~{h}-Purin-7-Ium-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]-4-Oxidanyl-Cyclobut-3-Ene-1,2-Dione | Ligand Info | |||||
| Structure Description | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | PDB:5EKV | ||||
| Method | X-ray diffraction | Resolution | 3.61 Å | Mutation | No | [4] |
| PDB Sequence |
PEHYIKHPLQ
40 NRWALWFFKN50 DKSKTWQANL60 RLISKFDTVE70 DFWALYNHIQ80 LSSNLMPGCD 90 YSLFKDGIEP100 MWEDEKNKRG110 GRWLITLNKQ120 QRRSDLDRFW130 LETLLCLIGE 140 SFDDYSDDVC150 GAVVNVRAKG160 DKIAIWTTEC170 ENREAVTHIG180 RVYKERLGLP 190 PKIVIGYQSH200 ADTATTKNRF215 VV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5PQ or .5PQ2 or .5PQ3 or :35PQ;style chemicals stick;color identity;select .A:56 or .A:57 or .A:90 or .A:100 or .A:101 or .A:102 or .A:103 or .A:112 or .A:155 or .A:157 or .A:162 or .A:166 or .A:203; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 7-[2-(4-Chlorophenoxy)ethyl]guanosine 5'-(Dihydrogen Phosphate) | Ligand Info | |||||
| Structure Description | Co-crystal structure of eIF4E with inhibitor | PDB:4DT6 | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [6] |
| PDB Sequence |
EVANPEHYIK
36 HPLQNRWALW46 FFKNDKSKTW56 QANLRLISKF66 DTVEDFWALY76 NHIQLSSNLM 86 PGCDYSLFKD96 GIEPMWEDEK106 NKRGGRWLIT116 LNKQQRRSDL126 DRFWLETLLC 136 LIGESFDDYS146 DDVCGAVVNV156 RAKGDKIAIW166 TTECENREAV176 THIGRVYKER 186 LGLPPKIVIG196 YQSHADTATK206 SKNRFVV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6LI or .6LI2 or .6LI3 or :36LI;style chemicals stick;color identity;select .A:46 or .A:47 or .A:48 or .A:56 or .A:60 or .A:90 or .A:91 or .A:92 or .A:100 or .A:101 or .A:102 or .A:103 or .A:112 or .A:153 or .A:155 or .A:157 or .A:162 or .A:166; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (4-{7-[2-(4-Chlorophenoxy)ethyl]-2-(Methylamino)-6-Oxo-6,7-Dihydro-1h-Purin-8-Yl}phenyl)phosphonic Acid | Ligand Info | |||||
| Structure Description | Co-crystal structure of eIF4E with inhibitor | PDB:4DUM | ||||
| Method | X-ray diffraction | Resolution | 2.95 Å | Mutation | No | [6] |
| PDB Sequence |
EVANPEHYIK
36 HPLQNRWALW46 FFKNDKSKTW56 QANLRLISKF66 DTVEDFWALY76 NHIQLSSNLM 86 PGCDYSLFKD96 GIEPMWEDEK106 NKRGGRWLIT116 LNKQQRRSDL126 DRFWLETLLC 136 LIGESFDDYS146 DDVCGAVVNV156 RAKGDKIAIW166 TTECENREAV176 THIGRVYKER 186 LGLPPKIVIG196 YQSHADTATK206 SKNRFVV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HLI or .HLI2 or .HLI3 or :3HLI;style chemicals stick;color identity;select .A:46 or .A:47 or .A:48 or .A:56 or .A:60 or .A:90 or .A:91 or .A:92 or .A:100 or .A:101 or .A:102 or .A:103 or .A:112 or .A:153 or .A:155 or .A:157 or .A:162 or .A:166; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2E)-3-(2-nitrophenyl)-2-[[4-(4-phenylphenyl)-1,3-thiazol-2-yl]hydrazinylidene]propanoic acid | Ligand Info | |||||
| Structure Description | A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders | PDB:7MEU | ||||
| Method | X-ray diffraction | Resolution | 1.91 Å | Mutation | No | [7] |
| PDB Sequence |
YIKHPLQNRW
43 ALWFFKNDKS53 KTWQANLRLI63 SKFDTVEDFW73 ALYNHIQLSS83 NLMPGCDYSL 93 FKDGIEPMWE103 DEKNKRGGRW113 LITLNKQQRR123 SDLDRFWLET133 LLCLIGESFD 143 DYSDDVCGAV153 VNVRAKGDKI163 AIWTTECENR173 EAVTHIGRVY183 KERLGLPPKI 193 VIGYQSHADT203 ATKSGSTTKN213 RFVV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Z5D or .Z5D2 or .Z5D3 or :3Z5D;style chemicals stick;color identity;select .A:45 or .A:66 or .A:72 or .A:75 or .A:76 or .A:79 or .A:80 or .A:81 or .A:83 or .A:84 or .A:85 or .A:91 or .A:93 or .A:123 or .A:127 or .A:130 or .A:134 or .A:154; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2E)-2-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]-3-(2-nitrophenyl)propanoic acid | Ligand Info | |||||
| Structure Description | The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G | PDB:4TPW | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [2] |
| PDB Sequence |
HYIKHPLQNR
42 WALWFFKNDK52 SKTWQANLRL62 ISKFDTVEDF72 WALYNHIQLS82 SNLMPGCDYS 92 LFKDGIEPMW102 EDEKNKRGGR112 WLITLNKQQR122 RSDLDRFWLE132 TLLCLIGESF 142 DDYSDDVCGA152 VVNVRAKGDK162 IAIWTTECEN172 REAVTHIGRV182 YKERLGLPPK 192 IVIGYQSHAD202 TATKSGSTTK212 NRFVV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .33R or .33R2 or .33R3 or :333R;style chemicals stick;color identity;select .A:45 or .A:47 or .A:48 or .A:49 or .A:54 or .A:58 or .A:59 or .A:60 or .A:61 or .A:63 or .A:75 or .A:78 or .A:79 or .A:82 or .A:83 or .A:89 or .A:91; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2e)-2-{2-[4-(4-Bromophenyl)-1,3-Thiazol-2-Yl]hydrazinylidene}-3-(2-Nitrophenyl)propanoic Acid | Ligand Info | |||||
| Structure Description | The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G | PDB:4TQB | ||||
| Method | X-ray diffraction | Resolution | 1.59 Å | Mutation | No | [2] |
| PDB Sequence |
HYIKHPLQNR
42 WALWFFKNDK52 SKTWQANLRL62 ISKFDTVEDF72 WALYNHIQLS82 SNLMPGCDYS 92 LFKDGIEPMW102 EDEKNKRGGR112 WLITLNKQQR122 RSDLDRFWLE132 TLLCLIGESF 142 DDYSDDVCGA152 VVNVRAKGDK162 IAIWTTECEN172 REAVTHIGRV182 YKERLGLPPK 192 IVIGYQSHAD202 TATKSGSTTK212 NRFVV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .34K or .34K2 or .34K3 or :334K;style chemicals stick;color identity;select .A:45 or .A:47 or .A:48 or .A:49 or .A:54 or .A:58 or .A:59 or .A:60 or .A:61 or .A:63 or .A:75 or .A:78 or .A:79 or .A:80 or .A:85 or .A:91; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 7N-Methyl-8-hydroguanosine-5'-triphosphate | Ligand Info | |||||
| Structure Description | The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G | PDB:4TQB | ||||
| Method | X-ray diffraction | Resolution | 1.59 Å | Mutation | No | [2] |
| PDB Sequence |
HYIKHPLQNR
42 WALWFFKNDK52 SKTWQANLRL62 ISKFDTVEDF72 WALYNHIQLS82 SNLMPGCDYS 92 LFKDGIEPMW102 EDEKNKRGGR112 WLITLNKQQR122 RSDLDRFWLE132 TLLCLIGESF 142 DDYSDDVCGA152 VVNVRAKGDK162 IAIWTTECEN172 REAVTHIGRV182 YKERLGLPPK 192 IVIGYQSHAD202 TATKSGSTTK212 NRFVV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MGT or .MGT2 or .MGT3 or :3MGT;style chemicals stick;color identity;select .A:52 or .A:56 or .A:57 or .A:90 or .A:100 or .A:101 or .A:102 or .A:103 or .A:112 or .A:153 or .A:155 or .A:157 or .A:159 or .A:162 or .A:166 or .A:203 or .A:204 or .A:206 or .A:207 or .A:208 or .A:209; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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LYS52
4.736
TRP56
2.850
GLN57
4.694
ASP90
4.751
PRO100
4.428
MET101
2.498
TRP102
1.976
GLU103
1.982
ARG112
3.880
VAL153
4.999
ASN155
3.895
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (2s)-3-(4-Amino-3-Nitrophenyl)-2-{2-[4-(3,4-Dichlorophenyl)-1,3-Thiazol-2-Yl]hydrazinyl}propanoic Acid | Ligand Info | |||||
| Structure Description | The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G | PDB:4TQC | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [2] |
| PDB Sequence |
IKHPLQNRWA
44 LWFFKNDKSK54 TWQANLRLIS64 KFDTVEDFWA74 LYNHIQLSMP87 GCDYSLFKDG 97 IEPMWEDEKN107 KRGGRWLITL117 NKQQRRSDLD127 RFWLETLLCL137 IGESFDDYSD 147 DVCGAVVNVR157 AKGDKIAIWT167 TECENREAVT177 HIGRVYKERL187 GLPPKIVIGY 197 QSHADTATKS207 KNRFVV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .34J or .34J2 or .34J3 or :334J;style chemicals stick;color identity;select .A:47 or .A:48 or .A:49 or .A:54 or .A:58 or .A:59 or .A:60 or .A:61 or .A:63 or .A:75 or .A:78 or .A:79 or .A:82 or .A:86; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region. Biochem J. 2002 Mar 15;362(Pt 3):539-44. | ||||
| REF 2 | Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3187-95. | ||||
| REF 3 | Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways | ||||
| REF 4 | Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur J Med Chem. 2016 Nov 29;124:200-217. | ||||
| REF 5 | Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives. J Mol Biol. 2007 Sep 7;372(1):7-15. | ||||
| REF 6 | Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction. J Med Chem. 2012 Apr 26;55(8):3837-51. | ||||
| REF 7 | A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders. Eur J Med Chem. 2021 Jul 5;219:113435. | ||||
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