Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T30985 Target Info
Target Name Histamine H2 receptor (H2R)
Synonyms Histamine receptor 2; HH2R; Gastric receptor I
Target Type Successful Target
Gene Name HRH2
Biochemical Class GPCR rhodopsin
UniProt ID
HRH2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Famotidine Ligand Info
Structure Description CryoEM Structure of Inactive H2R Bound to Famotidine, Nb6M, and NabFab PDB:7UL3
Method Electron microscopy Resolution 3.00 Å Mutation No [1]
PDB Sequence
ACKITITVVL
25
AVLILITVAG
35
NVVVCLAVGL
45
NRRLRNLTNC
55
FIVSLAITDL
65

LLGLLVLPFS
75
AIYQLSCKWS
85
FGKVFCNIYT
95
SLDVMLCTAS
105
ILNLFMISLD
115

RYCAVMDPLR
125
YPVLVTPVRV
135
AISLVLIWVI
145
SITLSFLSIH
155
LGWCKVQVNE
180

VYGLVDGLVT
190
FYLPLLIMCV
200
CYTLMILRLK
210
SVRLLSSREK
225
DRNLRRITRL
235

VLVVVAVFVI
245
CWFPYFTAFV
255
YRGLRGDDAI
265
NEVLEAIVLW
275
LGYANSALNP
285

ILYAALNRDF
295
RTGYQQLF
Residue
Distance (Å)
TYR94
4.905
ASP98
3.046
VAL99
3.756
CYS102
4.226
THR103
3.024
LEU149
4.986
CYS174
3.905
LYS175
3.246
VAL176
2.906
ASP186
2.950
Residue
Distance (Å)
THR190
3.515
TRP247
4.299
TYR250
3.267
PHE251
4.580
PHE254
3.999
ARG257
4.034
GLU270
4.014
LEU274
3.481
TYR278
3.808
References  Top
REF 1 Structure determination of inactive-state GPCRs with a universal nanobody. Nat Struct Mol Biol. 2022 Dec;29(12):1188-1195.

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