Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T30834 Target Info
Target Name Amylin receptor (IAPPR)
Synonyms Complex of Calcitonin receptor and Receptor activity-modifying protein
Target Type Clinical trial Target
Gene Name CALCR-RAMP1/RAMP2/RAMP3
UniProt ID
CALCR_HUMAN - RAMP1_HUMAN/RAMP2_HUMAN/RAMP3_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Olcegepant Ligand Info
Structure Description Crystal structure of a CGRP receptor ectodomain heterodimer with bound high affinity inhibitor PDB:6ZIS
Method X-ray diffraction Resolution 1.73 Å Mutation No [1]
PDB Sequence
SAKIEEGKLV
10
IWINGDKGYN
20
GLAEVGKKFE
30
KDTGIKVTVE
40
HPDKLEEKFP
50

QVAATGDGPD
60
IIFWAHDRFG
70
GYAQSGLLAE
80
ITPDKAFQDK
90
LYPFTWDAVR
100

YNGKLIAYPI
110
AVEALSLIYN
120
KDLLPNPPKT
130
WEEIPALDKE
140
LKAKGKSALM
150

FNLQEPYFTW
160
PLIAADGGYA
170
FKYENGKYDI
180
KDVGVDNAGA
190
KAGLTFLVDL
200

IKNKHMNADT
210
DYSIAEAAFN
220
KGETAMTING
230
PWAWSNIDTS
240
KVNYGVTVLP
250

TFKGQPSKPF
260
VGVLSAGINA
270
ASPNKELAKE
280
FLENYLLTDE
290
GLEAVNKDKP
300

LGAVALKSYE
310
EELAKDPRIA
320
ATMENAQKGE
330
IMPNIPQMSA
340
FWYAVRTAVI
350

NAASGRQTVD
360
EALKDAQTNA
370
AAEFTTACQE
1029
ANYGALLREL
1039
CLTQFQVDME
1049

AVGETLWCDW
1059
GRTIRSYREL
1069
ADCTWHMAEK
1079
LGCFWPNAEV
1089
DRFFLAVHGR
1099

YFRSCPISIQ
2033
LGVTRNKIMT
2043
AQYECYQKIM
2053
QDPIQQGVYC
2065
QRTWDGWLCW
2075

NDVAAGTESM
2085
QLCPDYFQDF
2095
DPSEKVTKIC
2105
DQDGNWFRHP
2115
ASQRTWTDYT
2125

QCNVNTHEKV
2135
KTALNLFYL
Residue
Distance (Å)
ALA1070
3.531
ASP1071
2.758
TRP1074
3.319
HIS1075
3.681
TRP1084
3.411
PRO1085
3.952
THR2037
4.999
ARG2038
3.872
ILE2041
3.723
MET2042
3.836
ASP2070
3.398
GLY2071
3.211
Residue
Distance (Å)
TRP2072
2.733
PHE2092
3.422
ASP2094
2.752
PHE2095
3.660
ARG2119
3.580
THR2120
4.384
TRP2121
3.339
THR2122
2.753
ASP2123
4.621
TYR2124
3.544
THR2125
3.867
ASN2128
4.108
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine. J Med Chem. 2020 Jul 23;63(14):7906-7920.

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