Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T30085 Target Info
Target Name Sodium/glucose cotransporter 2 (SGLT2)
Synonyms Solute carrier family 5 member 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter
Target Type Successful Target
Gene Name SLC5A2
Biochemical Class Solute:sodium symporter
UniProt ID
SC5A2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Empagliflozin Ligand Info
Structure Description Structure of human SGLT2-MAP17 complex bound with empagliflozin PDB:7VSI
Method Electron microscopy Resolution 2.95 Å Mutation No [1]
PDB Sequence
DNPADILVIA
30
AYFLLVIGVG
40
LWSMCRTNRG
50
TVGGYFLAGR
60
SMVWWPVGAS
70

LFASNIGSGH
80
FVGLAGTGAA
90
SGLAVAGFEW
100
NALFVVLLLG
110
WLFAPVYLTA
120

GVITMPQYLR
130
KRFGGRRIRL
140
YLSVLSLFLY
150
IFTKISVDMF
160
SGAVFIQQAL
170

GWNIYASVIA
180
LLGITMIYTV
190
TGGLAALMYT
200
DTVQTFVILG
210
GACILMGYAF
220

HEVGGYSGLF
230
DKYLGAATSL
240
TVSEDPAVGN
250
ISSFCYRPRP
260
DSYHLLRHPV
270

TGDLPWPALL
280
LGLTIVSGWY
290
WCSDQVIVQR
300
CLAGKSLTHI
310
KAGCILCGYL
320

KLTPMFLMVM
330
PGMISRILYP
340
DEVACVVPEV
350
CRRVCGTEVG
360
CSNIAYPRLV
370

VKLMPNGLRG
380
LMLAVMLAAL
390
MSSLASIFNS
400
SSTLFTMDIY
410
TRLRPRAGDR
420

ELLLVGRLWV
430
VFIVVVSVAW
440
LPVVQAAQGG
450
QLFDYIQAVS
460
SYLAPPVSAV
470

FVLALFVPRV
480
NEQGAFWGLI
490
GGLLMGLARL
500
IPEFSFGSGS
510
CVQPSACPAF
520

LCGVHYLYFA
530
IVLFFCSGLL
540
TLTVSLCTAP
550
IPRKHLHRLV
560
FSLRHSKEER
570

EDLDEDISED
646
PSWARVVNLN
656
ALLMMAVAVF
666
LWGFYA
Residue
Distance (Å)
ASN75
3.274
GLY79
4.021
HIS80
3.181
GLY83
3.564
LEU84
3.413
THR87
3.408
VAL95
3.319
PHE98
2.403
GLU99
3.242
ALA102
3.736
THR153
4.471
VAL157
3.728
LEU274
3.838
Residue
Distance (Å)
LEU283
4.153
VAL286
3.452
SER287
2.574
TYR290
3.763
TRP291
3.896
LYS321
3.221
PHE453
3.753
ASP454
2.988
ILE456
4.960
GLN457
3.255
SER460
4.386
TYR526
3.975
References  Top
REF 1 Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter. Nature. 2022 Jan;601(7892):280-284.

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