Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T27137 | Target Info | |||
| Target Name | Metabotropic glutamate receptor 1 (mGluR1) | ||||
| Synonyms | mGLUR1; Glutamate receptor mGLU1; GPRC1A | ||||
| Target Type | Discontinued Target | ||||
| Gene Name | GRM1 | ||||
| Biochemical Class | GPCR glutamate | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: [3H]LY341495 | Ligand Info | |||||
| Structure Description | Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist | PDB:3KS9 | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
QRSVARMDGD
44 VIIGALFSVH54 HQPPAEKVPE64 RKCGEIREQY74 GIQRVEAMFH84 TLDKINADPV 94 LLPNITLGSE104 IRDSCWHSSV114 ALEQSIEFIR124 DSLKPIAGVI160 GPGSSSVAIQ 170 VQNLLQLFDI180 PQIAYSATSI190 DLSDKTLYKY200 FLRVVPSDTL210 QARAMLDIVK 220 RYNWTYVSAV230 HTEGNYGESG240 MDAFKELAAQ250 EGLSIAHSDK260 IYSNAGEKSF 270 DRLLRKLRER280 LPKARVVVCF290 CEGMTVRGLL300 SAMRRLGVVG310 EFSLIGSDGW 320 ADRDEVIEGY330 EVEANGGITI340 KLQSPEVRSF350 DDYFLKLRLD360 TNTRNPWFPE 370 FWQHRFQCRL380 PGPNFKRICT395 GNESLEENYV405 QDSKMGFVIN415 AIYAMAHGLQ 425 NMHHALCPGH435 VGLCDAMKPI445 DGSKLLDFLI455 KSSFIGVSGE465 EVWFDEKGDA 475 PGRYDIMNLQ485 YTERYDYVHV497 GTWHEGVLNI507 DDYKI
|
|||||
|
|
||||||
| Ligand Name: CID 6971145 | Ligand Info | |||||
| Structure Description | intermediate state of class C GPCR | PDB:7DGE | ||||
| Method | Electron microscopy | Resolution | 3.65 Å | Mutation | Yes | [2] |
| PDB Sequence |
QRSVARMDGD
44 VIIGALFSVH54 HQPPAEKVPE64 RKCGEIREQY74 GIQRVEAMFH84 TLDKINADPV 94 LLPNITLGSE104 IRDSCWHSSV114 ALEQSIEFIR124 DSLIGRTKKP155 IAGVIGPGSS 165 SVAIQVQNLL175 QLFDIPQIAY185 SATSIDLSDK195 TLYKYFLRVV205 PSDTLQARAM 215 LDIVKRYNWT225 YVSAVHTEGN235 YGESGMDAFK245 ELAAQEGLCI255 AHSDKIYSNA 265 GEKSFDRLLR275 KLRERLPKAR285 VVVCFCEGMT295 VRGLLSAMRR305 LGVVGEFSLI 315 GSDGWADRDE325 VIEGYEVEAN335 GGITIKLQSP345 EVRSFDDYFL355 KLRLDTNHRN 365 PWFQEFWQHR375 FQCRLEGFPQ385 ENSNFKRICT395 GNESLEENYV405 QDSKMGFVIN 415 AIYAMAHGLQ425 NMHHALCPGH435 VGLCDAMKPI445 DGSKLLDFLI455 KSSFIGVSGE 465 EVWFDEKGDA475 PGRYDIMNLQ485 YTEANRYDYV495 HVGTWHEGVL505 NIDDYKIQMN 515 KSGVVRSVCS525 EPCLKGQIKV535 IRKGEVSCCW545 ICTACKENEY555 VQDEFTCKAC 565 DLGWWPNADL575 TGCEPIPVRY585 LEWSNIESII595 AIAFSCLGIL605 VTLFVTLIFV 615 LYRDTPVVKS625 SSRELCYIIL635 AGIFLGYVCP645 FTLIAKPTTT655 SCYLQRLLVG 665 LSSAMCYSAL675 VTKTNRIARI685 LAGSKKKICT695 RKPRFMSAWA705 QVIIASILIS 715 VQLTLVVTLI725 IMEPPMPILS735 YPSIKEVYLI745 CNTSNLGVVA755 PLGYNGLLIM 765 SCTYYAFKTR775 NVPANFNEAK785 YIAFTMYTTC795 IIWLAFVPIY805 FGSNYKIITT 815 CFAVSLSVTV825 ALGCMFTPKM835 YIII
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Metabotropic glutamate receptor mglur1 complexed with LY341495 antagonist | ||||
| REF 2 | Structural insights into the activation initiation of full-length mGlu1. Protein Cell. 2021 Aug;12(8):662-667. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.