Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T26983 | Target Info | |||
| Target Name | Tumor suppressor p53-binding protein 1 (TP53BP1) | ||||
| Synonyms | p53BP1; p53-binding protein 1; TP53-binding protein 1; 53BP1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | TP53BP1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 2-(4-Methyl-1-piperazinyl)aniline | Ligand Info | |||||
| Structure Description | Tudor Domain of Tumor suppressor p53BP1 with MFP-4184 | PDB:6VA5 | ||||
| Method | X-ray diffraction | Resolution | 1.28 Å | Mutation | No | [1] |
| PDB Sequence |
NSFVGLRVVA
1493 KWSSNGYFYS1503 GKITRDVGAG1513 KYKLLFDDGY1523 ECDVLGKDIL1533 LCDPIPLDTE 1543 VTALSEDEYF1553 SAGVVKGHRK1563 ESGELYYSIE1573 KEGQRKWYKR1583 MAVILSLEQG 1593 NRLREQYGLG1603 PYE
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| Ligand Name: 1-{4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzoyl}-4-ethylpiperazine | Ligand Info | |||||
| Structure Description | TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008 | PDB:6VIP | ||||
| Method | X-ray diffraction | Resolution | 1.36 Å | Mutation | No | [2] |
| PDB Sequence |
SFVGLRVVAK
1494 WSSNGYFYSG1504 KITRDVGAGK1514 YKLLFDDGYE1524 CDVLGKDILL1534 CDPIPLDTEV 1544 TALSEDEYFS1554 AGVVKGHRKE1564 SGELYYSIEK1574 EGQRKWYKRM1584 AVILSLEQGN 1594 RLREQYGLGP1604
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| Ligand Name: 3-Bromo-N-[3-(Tert-Butylamino)propyl]benzamide | Ligand Info | |||||
| Structure Description | Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand | PDB:4RG2 | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [3] |
| PDB Sequence |
SFVGLRVVAK
1494 WSSNGYFYSG1504 KITRDVGAGK1514 YKLLFDDGYE1524 CDVLGKDILL1534 CDPIPLDTEV 1544 TALSEDEYFS1554 AGVVKGHRKE1564 SGELYYSIEK1574 EGQRKWYKRM1584 AVILSLEQGN 1594 RLREQYGLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3OO or .3OO2 or .3OO3 or :33OO;style chemicals stick;color identity;select .A:1495 or .A:1502 or .A:1503 or .A:1519 or .A:1520 or .A:1521 or .A:1523 or .A:1547 or .A:1584; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-{[(2-chlorophenyl)methyl]sulfanyl}-4,5-dihydro-1H-imidazole | Ligand Info | |||||
| Structure Description | Tudor Domain of Tumor suppressor p53BP1 with MFP-2706 | PDB:6UPT | ||||
| Method | X-ray diffraction | Resolution | 1.96 Å | Mutation | No | [4] |
| PDB Sequence |
SFVGLRVVAK
1494 WSSNGYFYSG1504 KITRDVGAGK1514 YKLLFDDGYE1524 CDVLGKDILL1534 CDPIPLDTEV 1544 TALSEDEYFS1554 AGVVKGHRKE1564 SGELYYSIEK1574 EGQRKWYKRM1584 AVILSLEQGN 1594 RLREQYGLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .QFM or .QFM2 or .QFM3 or :3QFM;style chemicals stick;color identity;select .A:1495 or .A:1502 or .A:1503 or .A:1519 or .A:1520 or .A:1521 or .A:1523 or .A:1547 or .A:1584; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide | Ligand Info | |||||
| Structure Description | Structure of 53BP1 Tudor domains in complex with small molecule UNC3474 | PDB:6MXZ | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [5] |
| PDB Sequence |
SFVGLRVVAK
1494 WSSNGYFYSG1504 KITRDVGAGK1514 YKLLFDDGYE1524 CDVLGKDILL1534 CDPIPLDTEV 1544 TALSEDEYFS1554 AGVVKGHRKE1564 SGELYYSIEK1574 EGQRKWYKRM1584 AVILSLEQGN 1594 RLREQYGLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .K6S or .K6S2 or .K6S3 or :3K6S;style chemicals stick;color identity;select .A:1495 or .A:1498 or .A:1502 or .A:1503 or .A:1519 or .A:1520 or .A:1521 or .A:1523 or .A:1547 or .A:1584 or .A:1585 or .A:1587; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Tudor Domain of Tumor suppressor p53BP1 with MFP-4184 | ||||
| REF 2 | TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008 | ||||
| REF 3 | Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol. 2015 Apr 17;10(4):1072-81. | ||||
| REF 4 | Tudor Domain of Tumor suppressor p53BP1 with MFP-2706 | ||||
| REF 5 | Structure of 53BP1 Tudor domains in complex with small molecule UNC3474 | ||||
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