Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T26463 | Target Info | |||
Target Name | DNA polymerase alpha catalytic p180 (POLA1) | ||||
Synonyms | POLA; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha catalytic subunit | ||||
Target Type | Discontinued Target | ||||
Gene Name | POLA1 | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Aphidicolin | Ligand Info | |||||
Structure Description | Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and aphidicolin | PDB:4Q5V | ||||
Method | X-ray diffraction | Resolution | 2.52 Å | Mutation | Yes | [1] |
PDB Sequence |
EQVFHFYWLD
347 AYEDQYNQPG357 VVFLFGKVWI367 ESAETHVSCC377 VMVKNIERTL387 YFLPREMKID 397 LNTGKETGTP407 ISMKDVYEEF417 DEKIATKYKI427 MKFKSKPVEK437 NYAFEIPDVP 447 EKSEYLEVKY457 SAEMPQLPQD467 LKGETFSHVF477 GTNTSSLELF487 LMNRKIKGPC 497 WLEVKSPQLL507 NQPVSWCKAE517 AMALKPDLVN527 VIKDVSPPPL537 VVMAFSMKTM 547 QNAKNHQNEI557 IAMAALVHHS567 FALDKAAPKP577 PFQSHFCVVS587 KPKDCIFPYA 597 FKEVIEKKNV607 KVEVAATERT617 LLGFFLAKVH627 KIDPDIIVGH637 NIYGFELEVL 647 LQRINVCKAP657 HWSKIGRLKR667 SNMPKLGFGE681 RNATCGRMIC691 DVEISAKELI 701 RCKSYHLSEL711 VQQILKTERV721 VIPMENIQNM731 YSESSQLLYL741 LEHTWKDAKF 751 ILQIMCELNV761 LPLALQITNI771 AGNIMSRTLM781 GGRSERNEFL791 LLHAFYENNY 801 IVPDKQIRKK836 AAYAGGLVLD846 PKVGFYDKFI856 LLLDFNSLYP866 SIIQEFNICF 876 TTVQRVEQIP899 ELPDPSLEMG909 ILPREIRKLV919 ERRKQVKQLM929 KQQDLNPDLI 939 LQYDIRQKAL949 KLTANSMYGC959 LGFSYSRFYA969 KPLAALVTYK979 GREILMHTKE 989 MVQKMNLEVI999 YGDTDSIMIN1009 TNSTNLEEVF1019 KLGNKVKSEV1029 NKLYKLLEID 1039 IDGVFKSLLL1049 LKKKKYAALV1059 VEPTSDGNYV1069 TKQELKGLDI1079 VRRDWCDLAK 1089 DTGNFVIGQI1099 LSDQSRDTIV1109 ENIQKRLIEI1119 GENVLNGSVP1129 VSQFEINKAL 1139 TKDPQDYPDK1149 KSLPHVHVAL1159 WINSQGGRKV1169 KAGDTVSYVI1179 CQDGSNLTAS 1189 QRAYAPEQLQ1199 KQDNLTIDTQ1209 YYLAQQIHPV1219 VARICEPIDG1229 IDAVLIATWL 1239 GLDPT
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Ligand Name: 2'-Deoxycytidine-5'-triphosphate | Ligand Info | |||||
Structure Description | Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and dCTP | PDB:4QCL | ||||
Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | Yes | [2] |
PDB Sequence |
EQVFHFYWLD
347 AYEDQYNQPG357 VVFLFGKVWI367 ESAETHVSCC377 VMVKNIERTL387 YFLPREMKID 397 LNTGKETGTP407 ISMKDVYEEF417 DEKIATKYKI427 MKFKSKPVEK437 NYAFEIPDVP 447 EKSEYLEVKY457 SAEMPQLPQD467 LKGETFSHVF477 GTNTSSLELF487 LMNRKIKGPC 497 WLEVKSPQLL507 NQPVSWCKAE517 AMALKPDLVN527 VIKDVSPPPL537 VVMAFSMKTM 547 QNAKNHQNEI557 IAMAALVHHS567 FALDKAAPKP577 PFQSHFCVVS587 KPKDCIFPYA 597 FKEVIEKKNV607 KVEVAATERT617 LLGFFLAKVH627 KIDPDIIVGH637 NIYGFELEVL 647 LQRINVCKAP657 HWSKIGRLKR667 SNMPKLGFGE681 RNATCGRMIC691 DVEISAKELI 701 RCKSYHLSEL711 VQQILKTERV721 VIPMENIQNM731 YSESSQLLYL741 LEHTWKDAKF 751 ILQIMCELNV761 LPLALQITNI771 AGNIMSRTLM781 GGRSERNEFL791 LLHAFYENNY 801 IVPDKQIRKK836 AAYAGGLVLD846 PKVGFYDKFI856 LLLDFNSLYP866 SIIQEFNICF 876 TTVQRVEQIP899 ELPDPSLEMG909 ILPREIRKLV919 ERRKQVKQLM929 KQQDLNPDLI 939 LQYDIRQKAL949 KLTANSMYGC959 LGFSYSRFYA969 KPLAALVTYK979 GREILMHTKE 989 MVQKMNLEVI999 YGDTDSIMIN1009 TNSTNLEEVF1019 KLGNKVKSEV1029 NKLYKLLEID 1039 IDGVFKSLLL1049 LKKKKYAALV1059 VEPTSDGNYV1069 TKQELKGLDI1079 VRRDWCDLAK 1089 DTGNFVIGQI1099 LSDQSRDTIV1109 ENIQKRLIEI1119 GENVLNGSVP1129 VSQFEINKAL 1139 TKDPQDYPDK1149 KSLPHVHVAL1159 WINSQGGRKV1169 KAGDTVSYVI1179 CQDGSNLTAS 1189 QRAYAPEQLQ1199 KQDNLTIDTQ1209 YYLAQQIHPV1219 VARICEPIDG1229 IDAVLIATWL 1239 GLDPT
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Click to View More Binding Site Information of This Target and Ligand Pair |
References | Top | ||||
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REF 1 | Structural basis for inhibition of DNA replication by aphidicolin. Nucleic Acids Res. 2014 Dec 16;42(22):14013-21. | ||||
REF 2 | Activity and fidelity of human DNA polymerase alpha depend on primer structure |
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