Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T25317 Target Info
Target Name Cholestenol delta-isomerase (EBP)
Synonyms Emopamilbinding protein; EBP; Delta(8)Delta(7) sterol isomerase; D8D7 sterol isomerase; 3betahydroxysteroidDelta(8),Delta(7)isomerase
Target Type Clinical trial Target
Gene Name EBP
Biochemical Class Intramolecular oxidoreductases
UniProt ID
EBP_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Tamoxifen Ligand Info
Structure Description Structure of EBP and tamoxifen PDB:6OHU
Method X-ray diffraction Resolution 3.53 Å Mutation No [1]
PDB Sequence
PLHPYWPQHL
16
RLDNFVPNDR
26
PTWHILAGLF
36
SVTGVLVVTT
46
WLLSGRTWRR
63

LSLCWFAVCG
73
FIHLVIEGWF
83
VLYYEDLLGD
93
QAFLSQLWKE
103
YAKGDSRYIL
113

GDNFTVCMET
123
ITACLWGPLS
133
LWVVIAFLRQ
143
HPLRFILQLV
153
VSVGQIYGDV
163

LYFLTEHRDG
173
FQHGELGHPL
183
YFWFYFVFMN
193
ALWLVLPGVL
203
VLDAVKHLTH
213

AQSTLD
Residue
Distance (Å)
ILE31
4.749
LEU32
4.197
LEU35
3.475
PHE36
3.479
THR39
3.032
VAL71
4.449
PHE74
4.247
ILE75
3.340
ILE79
3.406
GLU80
3.170
LEU100
3.622
TRP101
3.690
Residue
Distance (Å)
GLU103
4.576
TYR104
4.017
TYR111
3.933
MET121
4.206
GLU122
4.219
ASP162
4.071
TYR165
3.908
PHE187
4.862
TYR188
3.198
MET192
3.563
ASN193
3.101
TRP196
3.518
Ligand Name: 3beta-(2-(Diethylamino)ethoxy)androst-5-en-17-one Ligand Info
Structure Description Structure of EBP and U18666A PDB:6OHT
Method X-ray diffraction Resolution 3.20 Å Mutation No [1]
PDB Sequence
PLHPYWPQHL
16
RLDNFVPNDR
26
PTWHILAGLF
36
SVTGVLVVTT
46
WLLSGRTWRR
63

LSLCWFAVCG
73
FIHLVIEGWF
83
VLYYEDLLGD
93
QAFLSQLWKE
103
YAKGDSRYIL
113

GDNFTVCETI
124
TACLWGPLSL
134
WVVIAFLRQH
144
PLRFILQLVV
154
SVGQIYGDVL
164

YFLTEHRDGF
174
QHGELGHPLY
184
FWFYFVFNAL
195
WLVLPGVLVL
205
DAVKHLTHAQ
215

STLD
Residue
Distance (Å)
THR28
3.774
ILE31
3.327
LEU32
3.323
LEU35
3.974
ILE75
4.504
HIS76
4.595
ILE79
4.540
GLU80
3.380
LEU100
3.550
TRP101
4.135
GLU103
4.568
Residue
Distance (Å)
TYR104
3.628
TYR111
4.029
GLU122
4.190
GLY161
4.519
ASP162
3.150
TYR165
3.528
PHE187
3.543
TYR188
3.380
ASN193
3.108
TRP196
3.392
Ligand Name: Selenomethionine Ligand Info
Structure Description Structure of EBP and U18666A PDB:6OHT
Method X-ray diffraction Resolution 3.20 Å Mutation No [1]
PDB Sequence
PLHPYWPQHL
16
RLDNFVPNDR
26
PTWHILAGLF
36
SVTGVLVVTT
46
WLLSGRTWRR
63

LSLCWFAVCG
73
FIHLVIEGWF
83
VLYYEDLLGD
93
QAFLSQLWKE
103
YAKGDSRYIL
113

GDNFTVCETI
124
TACLWGPLSL
134
WVVIAFLRQH
144
PLRFILQLVV
154
SVGQIYGDVL
164

YFLTEHRDGF
174
QHGELGHPLY
184
FWFYFVFNAL
195
WLVLPGVLVL
205
DAVKHLTHAQ
215

STLD
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MSE or .MSE2 or .MSE3 or :3MSE;style chemicals stick;color identity;select .A:111 or .A:117 or .A:118 or .A:119 or .A:120 or .A:122 or .A:123 or .A:124 or .A:125 or .A:161 or .A:165 or .A:186 or .A:187 or .A:188 or .A:189 or .A:190 or .A:191 or .A:193 or .A:194 or .A:195 or .A:196; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
TYR111
4.066
PHE117
3.005
THR118
3.025
VAL119
3.314
CYS120
1.331
GLU122
1.336
THR123
3.163
ILE124
2.974
THR125
3.130
GLY161
3.457
TYR165
4.058
Residue
Distance (Å)
TRP186
4.968
PHE187
3.080
TYR188
3.522
PHE189
4.661
VAL190
3.584
PHE191
1.331
ASN193
1.334
ALA194
3.167
LEU195
2.941
TRP196
3.185
References  Top
REF 1 Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition. Nat Commun. 2019 Jun 5;10(1):2452.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.