Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T25164 Target Info
Target Name Bacterial Flavohemoglobin (Bact hmp)
Synonyms Nitric oxide dioxygenase; NOD; NO oxygenase; Hemoglobin-like protein; HMP; Ferrisiderophore reductase B; Dihydropteridine reductase
Target Type Literature-reported Target
Gene Name Bact hmp
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
HMP_ECOLI
Drug Binding Sites of Target  Top
Ligand Name: Flavin-Adenine Dinucleotide Ligand Info
Structure Description The X-ray structure of ferric Escherichia coli flavohemoglobin reveals an unespected geometry of the distal heme pocket PDB:1GVH
Method X-ray diffraction Resolution 2.19 Å Mutation No [1]
PDB Sequence
MLDAQTIATV
10
KATIPLLVET
20
GPKLTAHFYD
30
RMFTHNPELK
40
EIFNMSNQRN
50

GDQREALFNA
60
IAAYASNIEN
70
LPALLPAVEK
80
IAQKHTSFQI
90
KPEQYNIVGE
100

HLLATLDEMF
110
SPGQEVLDAW
120
GKAYGVLANV
130
FINREAEIYN
140
ENASKAGGWE
150

GTRDFRIVAK
160
TPRSALITSF
170
ELEPVDGGAV
180
AEYRPGQYLG
190
VWLKPEGFPH
200

QEIRQYSLTR
210
KPDGKGYRIA
220
VKREEGGQVS
230
NWLHNHANVG
240
DVVKLVAPAG
250

DFFMAVADDT
260
PVTLISAGVG
270
QTPMLAMLDT
280
LAKAGHTAQV
290
NWFHAAENGD
300

VHAFADEVKE
310
LGQSLPRFTA
320
HTWYRQPSEA
330
DRAKGQFDSE
340
GLMDLSKLEG
350

AFSDPTMQFY
360
LCGPVGFMQF
370
TAKQLVDLGV
380
KQENIHYECF
390
GPHKVL
Residue
Distance (Å)
ASN44
2.966
SER46
2.353
GLN48
3.107
ARG49
4.533
ASN50
3.059
LYS84
4.375
TYR188
3.331
ARG204
3.543
GLN205
2.674
TYR206
2.236
SER207
2.959
ALA220
2.899
VAL221
3.336
LYS222
2.891
Residue
Distance (Å)
GLU224
3.549
GLU225
2.875
GLY226
3.905
GLY227
2.864
GLN228
3.159
VAL229
2.231
SER230
2.802
ASN231
4.858
VAL269
3.519
THR272
2.787
GLU388
3.645
CYS389
3.766
PHE390
3.364
GLY391
4.220
References  Top
REF 1 The X-ray structure of ferric Escherichia coli flavohemoglobin reveals an unexpected geometry of the distal heme pocket. J Biol Chem. 2002 Jun 28;277(26):23725-32.

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