Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T24127 Target Info
Target Name Peptide tyrosine tyrosine PYY (PYY)
Synonyms PYY-II
Target Type Clinical trial Target
Gene Name PYY
Biochemical Class NPY family
UniProt ID
PYY_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cyanocobalamin Ligand Info
Structure Description NMR solution structure of vitamin B12 conjugates of PYY3-36 PDB:2NA5
Method Solution NMR Resolution N.A. Mutation No [1]
PDB Sequence
IPEAPGEDAS
14
PEELNRYYAS
24
LRHYLNLVTR
34
QRY
Residue
Distance (Å)
ALA8
2.407
PRO9
2.468
GLY10
2.580
ALA13
4.560
SER14
2.012
Residue
Distance (Å)
GLU17
3.511
LEU18
2.886
TYR21
2.871
TYR22
4.255
Ligand Name: 6-[4-(2-aminoethyl)-1H-1,2,3-triazol-1-yl]-L-norleucine Ligand Info
Structure Description NMR solution structure of vitamin B12 conjugates of PYY3-36 PDB:2NA5
Method Solution NMR Resolution N.A. Mutation No [1]
PDB Sequence
IPEAPGEDAS
14
PEELNRYYAS
24
LRHYLNLVTR
34
QRY
Residue
Distance (Å)
ILE3
1.338
PRO6
1.344
GLU7
4.617
Residue
Distance (Å)
ALA8
4.303
TYR21
4.014
TYR28
3.724
References  Top
REF 1 Solution Structure and Constrained Molecular Dynamics Study of Vitamin B12 Conjugates of the Anorectic Peptide PYY(3-36). ChemMedChem. 2016 May 6;11(9):1015-21.

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